Results 51 to 60 of about 2,070,748 (278)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Study on the Anti-Frosting and Droplet Contact Characteristics of Fluorine-Based Self-Assembled Superhydrophobic Coating [PDF]
Cailiao BaohuIn order to study the effect of the cold surface on the anti-frosting performance of the superhydrophobic coating and the impact contact behavior of droplets, a fluorine-based self-assembled superhydrophobic coating was sprayed on the surface of carbon ...
YANG Jinglong, QIU Chao
doaj +1 more source
Frost Formation on Fan-Supplied Tube-Fin Evaporators: A Visual and Numerical Analysis [PDF]
, 2012 This paper presents an experimental and numerical study to evaluate the thermal-hydraulic performance of light commercial capacity evaporators operating under frosting conditions.
Da Silva, Diogo Londero
core +1 more source
A Highly Transparent, Self-Healing, and Durable Anti-Fogging Coating for Extreme Environments
LubricantsCondensation of water vapor into discrete droplets on the surface of transparent optical devices-commonly known as fogging-severely degrades their optical performance.
Jingtao Hu +4 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Evaporation-Rate Control of Water Droplets on Flexible Transparent Heater for Sensor Application
Sensors, 2019 To develop high-performance de- or anti-frosting/icing devices based on transparent heaters, it is necessary to study the evaporation-rate control of droplets on heater surfaces.
Jaesoung Park +6 more
doaj +1 more source