Results 71 to 80 of about 2,070,748 (278)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Ice‐Bridging Frustration by Self‐Ejection of Single Droplets Results in Superior Anti‐Frosting Surfaces

Advanced Materials Interfaces
Surfaces capable of delaying the frosting passively and facilitating its removal are highly desirable in fields where ice introduces inefficiencies and risks.
Nicolò G. Di Novo, Alvise Bagolini, Nicola M. Pugno   +2 more
doaj   +1 more source

SIMULATION AND EXPERIMENT OF MONORAIL ANTI-FROST MACHINE IN HILLY ORCHARD

INMATEH Agricultural Engineering
In order to solve the problems of artificial operation, high labor intensity and low efficiency of frost prevention in hilly orchards, this study takes hilly orchards as the research object. Based on the agronomic requirements of frost prevention in hilly orchards, a smoke anti-frost machine based on the transport track of hilly orchards is designed ...
Qingfu GONG, Yuepeng SONG, Wei MA, Hongmei ZHANG, Xiang HAN, Ang GAO, Longlong REN   +6 more
openaire   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Research on the Formation Characteristics of Fog and Frost on Optical Windows of Unsealed Equipment Compartments in Aircrafts

Energies
In this study, a numerical method for the formation and dissipation of fog and frost is established using the Eulerian multiphase flow liquid film model.
Chun Shen, Yuanyuan Liang, Bo Wei, Chengchun Zhang, Tian Zhao   +4 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Frosting Performance of Fin-and-Tube Evaporators with Small Copper Tubes Diameter [PDF]

, 2012
In modern heat pump systems, the heat exchangers use enhanced heat transfer surfaces for both air and refrigerant sides. In air conditioning applications, conventional 9.5 mm (3/8 inch) tube diameter fin-and-tube coils are slowly being replaced by ...
Cremaschi, Lorenzo, Padhmanabhan, Sankar, Moallem, Ehsan, Hong, Tommy, Fisher, Daniel E.   +4 more
core  

A Superhydrophobic Anti-Icing Surface with a Honeycomb Nanopore Structure

, 2023
Recently, the icing disaster of transmission lines has been a serious threat to the safe operation of the power system. A superhydrophobic (SHP) anti-icing surface with a honeycomb nanopore structure was constructed using anodic oxidation technology ...
Yuan Yuan, Xu Dai, Tao Zhu, Bo Li, Huiying Xiang, Xujiang Hua   +5 more
core   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source