Results 81 to 90 of about 3,164,975 (245)

New‐Onset Type 2 Diabetes Mellitus and Cancer Risk: A Matched Cohort Study in China Kadoorie Biobank

International Journal of Cancer, EarlyView.
ABSTRACT The prevalence of type 2 diabetes mellitus (T2DM) is rising rapidly in China and is linked to increased cancer risk, but causality remains unclear due to biases. We examined the causal effect of T2DM on cancer risk using bias‐minimizing methods.
Mengying Wang, Owen Tipping, Bowen Liu, Derrick A. Bennett, Baiyong Shen, Siyi Zou, Shulin Zhao, Richard M. Martin, Matthew Sperrin, Andrew G. Renehan   +9 more
wiley   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

The Clinicopathological Characteristics and Prognosis of Cholangiolocarcinoma: A Multicenter Study With a Central Pathology Review

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Cholangiolocarcinoma (CLC) is a rare liver cancer with ≥ 80% ductular configuration (DC). Given its rarity, its clinicopathological characteristics remain poorly understood, and its status as a distinct disease entity remains controversial.
Takamichi Ishii, Kenta Makino, Etsuro Hatano, Mina Komuta, Jun Akiba, Yoshihiro Sakamoto, Shun‐Ichi Ariizumi, Goro Honda, Toru Hisaka, Yutaka Takeda, Akira Shimizu, Kentaro Yasuchika, Takashi Mizuno, Daisuke Asano, Atsushi Fujio, Naoto Gotohda, Chie Kitami, Koji Amaya, Hiroshi Sadamori, Manabu Kawai, Akiyoshi Nakakura, Masafumi Nakamura, Itaru Endo   +22 more
wiley   +1 more source

THE EFFECT OF ISOLATION OF ANTI-HCV POSITIVE PATIENTS ON THE INCIDENCE OF HCV INFECTION IN A HEMODIALYSIS UNIT

Turkish Journal of Nephrology, 2019
İn this study, HD patients with anti-HCV positive and negative were dialysed in different rooms and seperate machines, and the effects of this isolation on anti-HCV seroconversion in the cases without HCV infection were investigated.
Ersin AKARSU, H.Zeki TONBUL, N.Yılmaz SELÇUK, Ramazan ÇETİNKAYA, Ayla SAN   +4 more
doaj  

European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) position paper on screening, diagnosis and investigation of paediatric metabolic dysfunction‐associated steatotic liver disease

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common reason for elevated liver enzymes in children in Europe, affecting more than 5% of all children. Since the last iteration of this position paper, there have been substantial advances in our understanding of the disease.
Jake P. Mann, Sander Lefere, Maarten Buytaert, Anna Alisi, Cigdem Arikan, Jernej Brecelj, Rachel M. Brown, Irene Degrassi, Giulia Fiore, Emer Fitzpatrick, Sven Francque, Christian A. Hudert, Wojciech Janczyk, Lauren Johansen, Bart G. Koot, Anastasia Konidari, Eberhard Lurz, Claudia Mandato, Maria Mercadal‐Hally, Hadar Moran‐Lev, Antonella Mosca, Giusy Ranucci, Maria Rogalidou, Penelope C. Rose, Piotr Socha, Pietro Vajro, Elvira Verduci, Anita C. E. Vreugdenhil, Natalia Zavhorodnia, Aglaia Zellos, Ruth De Bruyne   +30 more
wiley   +1 more source

JAK Inhibitors in Psoriatic–Atopic Dermatitis Overlap: A Four‑Case Series

JEADV Clinical Practice, EarlyView.
ABSTRACT Overlap between psoriasis and atopic dermatitis (AD) poses diagnostic and therapeutic challenges; monoclonal antibodies targeting a single axis may improve one component while worsening the other [1]. Janus kinase (JAK) inhibitors act pleiotropically and may provide simultaneous control of psoriatic and eczematous inflammation [2].
Eleonora Bongiovanni, Francois Rosset, Isotta Giunipero di Corteranzo, Lorenzo Bellando, Rebecca Senetta, Simone Ribero, Pietro Quaglino   +6 more
wiley   +1 more source

THE RELATIONSHIP BETWEEN ANTI-HCV IgM AND VIREMIA (HCV-RNA) IN THE HEMODIALYSIS PATIENTS WITH CHRONIC HCV INFECTION.

Turkish Journal of Nephrology, 2019
İn the present study, anti-HCV IgM (EIA, Abbott), HCV-RNA by PCR and alanine aminotransferase (ALT) levels were determined in 30 hemodialysis patients (16 F, 14 M) detected for anti-HCV positivity (ELISA-I1, Abbott) at least for 6 months, and the ...
H.Zeki TONBUL, Yılmaz SELÇUK, Mehmet TAŞYARAN, Ayla SAN, İlyas ÇAPOĞLU, Ramazan ÇETİNKAYA   +5 more
doaj  

Interactive Roles of Metabolic Dysfunction‐Associated Steatotic Liver Disease and Nutritional Status in the Prognosis of Patients With Hepatocellular Carcinoma After Surgical Resection

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The prognostic effect of concurrent metabolic dysfunction‐associated steatotic liver disease (MASLD) on outcomes for hepatocellular carcinoma (HCC) patients remains unclear. The Prognostic Nutritional Index (PNI) reflects nutritional and inflammatory status and is a well‐known prognostic factor.
Chun‐Ting Ho, Chien‐An Liu, Chia‐Jung Ho, Yi‐Chen Lin, Shin‐Yu Tsai, Hao‐Jan Lei, Shu‐Cheng Chou, Yi‐Hsiang Huang, Ming‐Chih Hou, Jaw‐Ching Wu, Chien‐Wei Su   +10 more
wiley   +1 more source

Dual strategy involving hospital-based study and community-based screening to eliminate hepatitis C in remote areas

Journal of the Formosan Medical Association
Background: /Purpose: To achieve the World Health Organization goal of eliminating viral hepatitis by 2030, a key strategy in resource-limited areas is to identify the areas with high prevalence and to prioritize screening and treatment intervention.
Chien-Hung Chen, Nien-Tzu Hsu, I-Chun Chen, Te-Sheng Chang, Shing Cheng, Shi-Yann Cheng, Hung-Ming Chen, Ming-Rong Harn, Chen-Kou Liu, Mao-Ting Yang, Shih-Lung Lu, Chun-Mei Tseng, Sheng-Nan Lu   +12 more
doaj   +1 more source

Circulating Omega‐3 Fatty Acids and Cardiometabolic Outcomes: A Systematic Review of Publications From UK Biobank

Lipids, EarlyView.
ABSTRACT Studies have shown that omega‐3 fatty acids may protect against cardiovascular diseases (CVDs) and related metabolic conditions. UK Biobank is a large cohort study that includes data on plasma omega‐3 fatty acids at study entry and health outcomes during the follow‐up period.
Warda Tul Firdous, Philip C. Calder
wiley   +1 more source