Results 81 to 90 of about 98,145 (299)

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Seroprevalence of hepatitis B virus and its co-infection with hepatitis D virus and hepatitis C virus in Iranian adult population [PDF]

, 2007
Context: Hepatitis B virus (HBV) infection is one of the most prevalent public health problems worldwide (especially in developing countries). Aims: This study was carried out to determine the seroprevalence of HBV and its co-infection with hepatitis D ...
Abbasali, K., Abdolvahab, M., Danyal, R., Gholamreza, R., Hamidreza, J., Khodaberdi, K., Nafiseh, A., Shahryar, S.   +7 more
core  

JAK Inhibitors in Psoriatic–Atopic Dermatitis Overlap: A Four‑Case Series

JEADV Clinical Practice, EarlyView.
ABSTRACT Overlap between psoriasis and atopic dermatitis (AD) poses diagnostic and therapeutic challenges; monoclonal antibodies targeting a single axis may improve one component while worsening the other [1]. Janus kinase (JAK) inhibitors act pleiotropically and may provide simultaneous control of psoriatic and eczematous inflammation [2].
Eleonora Bongiovanni, Francois Rosset, Isotta Giunipero di Corteranzo, Lorenzo Bellando, Rebecca Senetta, Simone Ribero, Pietro Quaglino   +6 more
wiley   +1 more source

Treatment initiation rates of patients with positive anti-hepatitis C virus results in tertiary hospitals in Turkey

Journal of Infection in Developing Countries
Introduction: The aim of this national, multicenter, cross-sectional, retrospective chart review study was to determine the proportion of patients in Turkey who received hepatitis C virus (HCV) treatment after receiving positive anti-HCV results during ...
Mustafa K Çelen, Buket Ertürk Şengel, Şafak Kaya, Neşe Demirtürk, Alpay Azap, Hüsnü Pullukçu, Esma Eroğlu, Figen Yıldırım, Hüseyin Ş Barut, Esra Zerdali, Ayşe Sağmak Tartar, Ayşe Ö Mete, Ahmet M Şahin, Bedia Mutay Suntur, Nagehan D Sarı, Emel Yılmaz, Aslıhan Candevir, Funda Şimşek, Dilara İnan, Sıla Akhan, Ali Asan, Özgür Günal, Onur Ural, Mehmet Parlak, Mehmet Çabalak, Selçuk Nazik, Kenan Hızel, Sami Kınıklı, Zehra Beştepe Dursun, Ayşe Batırel, Çiğdem Mermutluoğlu   +30 more
doaj   +1 more source

The stability analyses of the mathematical models of hepatitis C virus infection [PDF]

, 2015
There are two mathematical models of Hepatitis C virus (HCV) being discussed; the original model of HCV viral dynamics (Neumann et al., 1998) and its extended model (Dahari et al., 2007). The key aspects of the mathematical models have provided resources
Chong, Maureen Siew Fang, Crossley, Laurie, Madzvamuse, Anotida, Shahrill, Masitah   +3 more
core   +1 more source

Anti-HCV antibodies: A battle for breadth and potency

Antiviral Research
Abstract Potent and broadly neutralizing antibodies (NAbs) are important for clearance of RNA virus infections. However, NAbs generated in response to RNA viruses exhibit diverse profiles of potency and breadth. In this study, we conducted a comparative analysis of NAbs targeting HIV, hepatitis C virus (HCV), SARS-CoV-2, and influenza based on ...
Elham, Jamali, Ahmed Abdul, Quadeer, Nicodemus, Tedla, Matthew R, McKay, Andrew, Lloyd, Melanie R, Walker, Rowena A, Bull   +6 more
openaire   +2 more sources

Antibodies to hepatitis A virus in Italian patients with chronic liver disease [PDF]

, 2001
To improve our knowledge for future hepatitis A virus (HAV) vaccination strategies we carried out a multicentre study on naturally acquired immunological protection against HAV in patients with chronic hepatitis in Italy.
Sagnelli, Evangelista, Rossi, Giovanni, Coppola, Nicola, Scolastico, Carlo, Onofrio, Mirella, Filippini, Pietro, Chiaramonte, Maria, Pizzigallo, Eligio, Aceti, Antonio, Spadaro, Aldo, Raimondo, Giovanni, Piccinino, Felice   +11 more
core  

Hepatitis C virus pharmacogenomics in Latin American populations: implications in the era of direct-acting antivirals [PDF]

, 2017
In recent years, great progress has been made in the field of new therapeutic options for hepatitis C virus (HCV) infection. The new direct-acting antiviral agents (DAAs) represent a great hope for millions of chronically infected individuals because ...
Caputo, Mariela, Corach, Daniel, Flichman, Diego Martin, Hulaniuk, María L., Trinks, Julieta   +4 more
core   +1 more source

Seropositivity of Hepatitis B virus and Hepatitis C virus dual Infection among blood donors in Nyala Teaching Hospital [PDF]

, 2009
The aim of this study was to determine the seropositivity of Hepatitis B virus (HBV) and Hepatitis C virus (HCV) dual infection among blood donors in Nyala Teaching Hospital, which is the biggest (400 beds) hospital in great Dar Fur of Western Sudan. 400
Mustafa Abou, Yassir Eltahir
core   +1 more source

Current approaches for developing new anti-HCV agents and analyses of HCV replication using anti-HCV agents

Uirusu, 2005
Currently, patients with hepatitis C virus (HCV) are mainly treated with interferon alone or in combination with ribavirin. However, because the virus is not eliminated from approximately one half of the patients by this treatment, alternative approaches to the treatment of HCV infection are needed.
Koichi, Watashi, Kunitada, Shimotohno
openaire   +3 more sources