Results 71 to 80 of about 98,145 (299)

Design Space Assessment of Virus Inactivation in Plasma‐Derived Matrices Establishes a Single Detergent Alternative to TX‐100‐Containing Mixes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The detergent Triton X‐100 (TX‐100) is a typical component of solvent/detergent (S/D) mixes applied for virus inactivation steps of biomanufacturing processes, yet environmentally unfavorable properties have led to restrictions on its use. Deviron 13‐S9 has recently been described as an eco‐friendly TX‐100 alternative, with powerful virus ...
Johanna Kindermann, Cecilie Klausen, Michael Karbiener, Thomas R. Kreil   +3 more
wiley   +1 more source

Standardized Management Pathway to Prevent Acute Rejection After Liver Transplantation Following ICI Therapy for Downstaging HCC

Health Care Science, EarlyView.
Findings indicate that within a standardized clinical pathway integrating structured immunosuppression, therapeutic drug monitoring, and early complication surveillance, liver transplantation after ICI exposure can be performed safely without increased rejection risk.
Ning Wang, Zebin Zhu, Hao Zheng, Can Qi, Xiaodong Yuan, Xuefeng Li, Zhijun Xu, Jiwei Qin, Wei Wu, Jizhou Wang, Ruipeng Song, Zhiyong Guo, Lianxin Liu, Shu‐Geng Zhang, Björn Nashan   +14 more
wiley   +1 more source

Recent advances in the anti-HCV mechanisms of interferon

Acta Pharmaceutica Sinica B, 2014
Interferon (IFN) in combination with ribavirin has been the standard of care (SOC) for chronic hepatitis C for the past few decades. Although the current SOC lacks the desired efficacy, and 4 new direct-acting antiviral agents have been recently approved, interferons are still likely to remain the cornerstone of therapy for some time.
Menghao Huang, Jian-Dong Jiang, Zonggen Peng   +2 more
openaire   +3 more sources

Prevalence of Sero-Molecular Markers of Hepatitis C and B Viruses among Patients with β-Thalassemia Major in Northern West Bank, Palestine

Canadian Journal of Infectious Diseases and Medical Microbiology, 2018
Background. HCV and HBV present a great challenge in the management of β-thalassemia patients. Objective. The present study aimed to determine the prevalence of both HBV and HCV in multitransfused-dependent β-thalassemia patients in northern West Bank ...
Kamal Dumaidi, Amer Al-Jawabreh, Fekri Samarah, Maha Rabayaa   +3 more
doaj   +1 more source

Hepatites pós-transfusionais na cidade de Campinas, SP, Brasil: II. Presença dos anticorpos anti-HBc e anti-HCV em candidatos a doadores de sangue e ocorrência de hepatites pós-transfusionais pelo vírus C nos receptores de sangue ou derivados Post-transfusional hepatitis in the city of Campinas, SP, Brazil: II- Presence of anti-HBc and anti-HCV antibodies in blood donors and occurrence of post-transfusional hepatitis C virus in recipients of blood or derivates

Revista do Instituto de Medicina Tropical de São Paulo, 1993
Pesquisamos os anticorpos anti-HBc e anti-HCV em amostras de soros provenientes de 799 candidatos a doadores, que tiveram suas unidades de sangue ou derivados transfundidas a 111 receptores. O anti-HBc e o anti-HCV foram reagentes, em respectivamente 9 e
Fernando Lopes Gonçales Júnior, Rogério de Jesus Pedro, Luiz Jacintho da Silva, Raquel Silveira Bello Stucchi Boccato, Neiva Sellan Lopes Gonçales   +4 more
doaj   +1 more source

Clin Infect Dis [PDF]

BackgroundHepatitis C virus (HCV) testing guidance issued by the Centers for Disease Control and Prevention in 1998 recommends HCV antibody (anti-HCV) testing for persons with specified risk factors.

core  

Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy [PDF]

, 2014
Hepatitis C virus (HCV) infection represents an important public health problem worldwide. Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors.
Carpio Pedroza, Juan Carlos, Cruz Rivera, Mayra, Escobar Gutierrez, Alejandro, Fonseca Coronado, Salvador, Martinez Guarneros, Armando, Preciado, María Victoria, Rahal, Paula, Ruiz Tovar, Karina, Valva, Pamela, Vazquez Chacon, Carlos, Yamasaki, Lilian   +10 more
core   +1 more source

[Anti-HCV seropositivity in dialysis patients].

Revista de saude publica, 2006
Estudo transversal para verificar a prevalência de anticorpos contra hepatite em pacientes dialisados e fatores associados. Foi realizada revisão de prontuários de todos os pacientes dialisados (n=1.261) de Porto Alegre, RS, de agosto a dezembro de 2003. Os testes estatísticos aplicados foram o qui-quadrado e o teste de tendência linear.
Gomes, Marcia, Gigante, Luciana Petrucci, Gomes, Jane, Boschetti, Jaqueline, Carvalho, Glayds   +4 more
openaire   +2 more sources

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Evaluation of biochemical, hematological, RIBA and PCR assays in predicting viremia in anti-HCV positive patients

Journal of Infection in Developing Countries, 2019
Introduction: The detection of HCV-RNA by PCR assays is considered to be the gold standard for confirming the presence of HCV viremia. However, high costs, long and laborious procedures limit their widespread usage.
Mumtaz Cem Sirin, Buket Cicioglu Aridogan, Emel Sesli Cetin, Fevziye Burcu Sirin   +3 more
doaj   +1 more source