Results 101 to 110 of about 357,237 (305)
Biomedical and Biotechnology Research Journal, 2018 Introduction: Malaise involves general discomfort, uneasiness, or pain which could indicate microbial infection or other diseases which could be as a result of immune response.
Mathew Folaranmi Olaniyan +1 more
doaj +1 more source
Identification of a novel retroviral gene unique to human immunodeficiency virus type 2 and simian immunodeficiency virus SIVMAC [PDF]
, 1988 Human and simian immunodeficiency-associated retroviruses are extraordinarily complex, containing at least five genes, tat, art, sor, R, and 3' orf, in addition to the structural genes gag, pol, and env.
Hahn, Beatrice H. +7 more
core
Antibody engineering for increased potency, breadth and half-life [PDF]
, 2015 Purpose of review: This review highlights recent developments in HIV-1 antibody engineering and discusses the effects of increased polyreactivity on serum half-lives of engineered antibodies.
Bjorkman, Pamela J. +3 more
core +1 more source
Advanced Science, EarlyView.This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang +10 more
wiley +1 more source
Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages. [PDF]
, 1987 Primary human monocyte-derived macrophages (MDM) were shown to have diminished deoxynucleoside kinase activities compared to T lymphoblasts, and a reduced ability to phosphorylate dideoxynucleosides with anti-human immunodeficiency virus (HIV) activity ...
Carson, DA, Kornbluth, RS, Richman, DD
core
Advanced Science, EarlyView.(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin +12 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley +1 more source
Communications MedicineBackground Despite efforts to eliminate malaria in Sao Tome and Principe (STP), cases have recently increased. Understanding residual transmission structure is crucial for developing effective elimination strategies.
Ying‑An Chen +10 more
doaj +1 more source
The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. [PDF]
, 2017 Despite effective treatment for those living with Human Immunodeficiency Virus (HIV), there are still two million new infections each year. Protein-based HIV entry inhibitors, being highly effective and specific, could be used to protect people from ...
F Nguyen, Anna +3 more
core +2 more sources
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source