Results 1 to 10 of about 98,046 (200)

New preclinical antimalarial drugs potently inhibit hepatitis C virus genotype 1b RNA replication. [PDF]

PLoS ONE, 2013
BACKGROUND: Persistent hepatitis C virus (HCV) infection causes chronic liver diseases and is a global health problem. Although new triple therapy (pegylated-interferon, ribavirin, and telaprevir/boceprevir) has recently been started and is expected to ...
Youki Ueda, Midori Takeda, Kyoko Mori, Hiromichi Dansako, Takaji Wakita, Hye-Sook Kim, Akira Sato, Yusuke Wataya, Masanori Ikeda, Nobuyuki Kato   +9 more
doaj   +28 more sources

Feasibility of anti-HCV reflex HCV Ag screening strategy in an HCV endemic community

Journal of the Formosan Medical Association, 2021
Background/Purpose: The HCV core antigen (HCV Ag) assay displays high sensitivity and strong correlation with HCV RNA. However, the feasibility of anti-HCV reflex HCV Ag screening in a community-wide setting is rarely discussed.
Wei-Ming Chen, Chih-Yi Lee, Nien-Tzu Hsu, Wei-Cheng Huang, Mei-Yen Chen, Tung-Jung Huang, Sheng-Nan Lu   +6 more
doaj   +3 more sources

Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection. [PDF]

PLoS ONE, 2021
Background/aimsHepatitis C Virus (HCV) infection is diagnosed by the presence of antibody to HCV and/or HCV RNA. This study aimed to evaluate the accuracy of anti-HCV titer (S/CO ratio) in predicting HCV viremia in patients with or without hepatitis B ...
Hung-Yin Liu, Yi-Hung Lin, Pei-Ju Lin, Pei-Chien Tsai, Shu-Fen Liu, Ying-Chou Huang, Jia-Jiun Tsai, Ching-I Huang, Ming-Lun Yeh, Po-Cheng Liang, Zu-Yau Lin, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Chung-Feng Huang, Ming-Lung Yu   +15 more
doaj   +2 more sources

The role of a two-assay serological testing strategy for anti-HCV screening in low-prevalence populations [PDF]

Scientific Reports, 2021
HCV screening depends mainly on a one-assay anti-HCV testing strategy that is subject to an increased false-positive rate in low-prevalence populations.
Yanfang Huang, Huifen Pan, Qin Gao, Panpan Lv, Xiaoqin Xu, Zhen Zhao   +5 more
doaj   +2 more sources

Sustained Long-Term Decline in Anti-HCV Neutralizing Antibodies in HIV/HCV-Coinfected Patients Five Years after HCV Therapy: A Retrospective Study [PDF]

Pharmaceuticals
Background: This study evaluated titers and amplitudes of anti-E2 antibodies (anti-E2-Abs) and neutralizing antibodies against hepatitis C virus (HCV; anti-HCV-nAbs) in HIV/HCV-coinfected individuals over five years after successful HCV treatment ...
Daniel Sepúlveda-Crespo, Camilla Volpi, Rafael Amigot-Sánchez, María Belén Yélamos, Cristina Díez, Julián Gómez, Víctor Hontañón, Juan Berenguer, Juan González-García, Rubén Martín-Escolano, Salvador Resino, Isidoro Martínez   +11 more
doaj   +2 more sources

Artemisinin analogues as potent inhibitors of in vitro hepatitis C virus replication. [PDF]

PLoS ONE, 2013
We reported previously that Artemisinin (ART), a widely used anti-malarial drug, is an inhibitor of in vitro HCV subgenomic replicon replication. We here demonstrate that ART exerts its antiviral activity also in hepatoma cells infected with full length ...
Susan Obeid, Jo Alen, Van Hung Nguyen, Van Cuong Pham, Philip Meuleman, Christophe Pannecouque, Thanh Nguyen Le, Johan Neyts, Wim Dehaen, Jan Paeshuyse   +9 more
doaj   +6 more sources

The diagnostic significance of hepatitis C virus antibody levels for chronic hepatitis C virus infection [PDF]

The Korean Journal of Internal Medicine, 2023
Background/Aims Although anti-hepatitis C virus (HCV) assay is widely used to screen for HCV infection, it has a high false-positive (FP) rate in low-risk populations.
Jin Gu Kang, Myoung Kuk Jang, Jung Hee Kim, Jang Han Jung, Ji Won Park, Sung Eun Kim, Sang Hoon Park, Myung Seok Lee, Ki Tae Suk, Dong Joon Kim, Hyoung Su Kim   +10 more
doaj   +1 more source

Anti-HCV drugs in the pipeline [PDF]

Current Opinion in Virology, 2011
Several directly acting and host targeting antivirals that inhibit hepatitis C virus replication have entered clinical trials. Among the most advanced of these are RG7128, an inhibitor of the NS5B polymerase; BMS-790052, an inhibitor of NS5A; and alisporivir, an inhibitor of human cyclophilins. These agents have potent antiviral activity in chronic HCV
Priscilla L, Yang, Min, Gao, Kai, Lin, Qingsong, Liu, Valerie A, Villareal   +4 more
openaire   +2 more sources

Prevalence and characteristics of hepatitis C virus infection in Shenyang City, Northeast China, and prediction of HCV RNA positivity according to serum anti-HCV level: retrospective review of hospital data

Virology Journal, 2020
Objective The prevalence of hepatitis C virus (HCV) infection is typically evaluated based on the current rate of positivity of anti-HCV antibody; however, HCV RNA positivity is considered the main criterion for antiviral treatment of HCV infection in ...
Yurong Li, Lianrong Zhao, Nan Geng, Weijia Zhu, Hongbo Liu, Han Bai   +5 more
doaj   +1 more source

Prevalence, Awareness, and Treatment of Hepatitis C Virus Infection in South Korea: Evidence from the Korea National Health and Nutrition Examination Survey

Gut and Liver, 2020
Background/Aims: This study aimed to investigate the epidemiology of hepatitis C virus (HCV) infection in the Korean general population and the awareness and treatment status of HCV infection among anti-HCV-positive persons.
Kyung-Ah Kim, June Sung Lee
doaj   +1 more source