Results 41 to 50 of about 3,164,975 (245)

Community screening for hepatitis C virus infection in a low-prevalence population

BMC Public Health, 2019
Background Age cohort screening for hepatitis C virus (HCV) might be an effective strategy if the majority of undiagnosed cases are concentrated in a particular age group.
Karen K. Kyuregyan, Elena Yu. Malinnikova, Natalia V. Soboleva, Olga V. Isaeva, Anastasia A. Karlsen, Vera S. Kichatova, Ilya A. Potemkin, Elena V. Schibrik, Olga A. Gadjieva, Boris A. Bashiryan, Natalya N. Lebedeva, Igor L. Serkov, Anna Yankina, Claudio Galli, Mikhail I. Mikhailov   +14 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The management of blood donors tested reactive to HCV in blood screening based on confirmation of HCV infection

Zhongguo shuxue zazhi
[Objective] To explore the management of blood donors tested reactive to HCV in blood screening based on confirmation of HCV infection. [Methods] Multiple HCV antibody assays, repeating HCV RNA testing, follow-up of blood donors and retesting of archive ...
DENG Xuelian, ZANG Liang, GONG Xiaofang, ZHOU Lei, LIU Xiaochun, WANG Lin, WANG Lunan   +6 more
doaj   +1 more source

HCV-RNA and Anti-HCV IgM in Egyptian Subjects Bearing IgG Anti-HCV Antibodies

Japanese Journal of Infectious Diseases, 1999
The hepatitis C virus (HCV) infection is associated with a wide spectrum of clinical entities ranging from asymptomatic carriage to severe forms of chronic hepatitis. In Egypt, HCV infection has been shown to be highly prevalent. The aim of this study was to determine the frequency and significance of anti-HCV IgM in the sera of clinically healthy ...
EI-Gohary, Ahmed, Hosny, Abdel-Moneim, Fawaz, Naglaa, Heiba, Anwar, Abdalla, Essam, Kawano, Fumio, Kiyokawa, Tetsuyuki   +6 more
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Longitudinal study of a human drug-induced model of autoantibody to cytoplasmic rods/rings following HCV therapy with ribavirin and interferon-α. [PDF]

PLoS ONE, 2012
A novel pattern in the indirect immunofluorescence antinuclear antibody assay on HEp-2 cells (IIF-HEp-2) characterized by cytoplasmic rods and rings (RR) was reported in HCV patients, but stringent disease specificity studies and longitudinal analysis ...
Gerson Dierley Keppeke, Eunice Nunes, Maria Lucia Gomes Ferraz, Eduardo Antônio Benedito Silva, Celso Granato, Edward K L Chan, Luís Eduardo C Andrade   +6 more
doaj   +1 more source

Screening for anti HCV

Annals of King Edward Medical University, 2016
Purpose of this study is to evaluate the different indications for screening for Anti HCV. This study was carried out in outdoor and indoor department of North Medical Ward of Mayo Hospital, Lahore. This is a non-interventional observational study.
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Sustained Long-Term Decline in Anti-HCV Neutralizing Antibodies in HIV/HCV-Coinfected Patients Five Years after HCV Therapy: A Retrospective Study

Pharmaceuticals
Background: This study evaluated titers and amplitudes of anti-E2 antibodies (anti-E2-Abs) and neutralizing antibodies against hepatitis C virus (HCV; anti-HCV-nAbs) in HIV/HCV-coinfected individuals over five years after successful HCV treatment ...
Daniel Sepúlveda-Crespo, Camilla Volpi, Rafael Amigot-Sánchez, María Belén Yélamos, Cristina Díez, Julián Gómez, Víctor Hontañón, Juan Berenguer, Juan González-García, Rubén Martín-Escolano, Salvador Resino, Isidoro Martínez   +11 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source