Results 261 to 270 of about 357,237 (305)
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Increasing number of anti-HIV drugs but no definite cure Review of anti-HIV drugs
Pharmacy World & Science, 2004This review surveys the different classes of drugs.We searched electronic databases and selected articles about pharmacotherapy with anti-retroviral drugs.We discuss anti-retroviral drugs: the nucleotide reverse transcriptase inhibitors (NRTIs), the non-nucleoside reverse transcriptase inhibitors (NNRTIs), and the protease inhibitors (PIs).
Leo M L, Stolk, Jos F J, Lüers
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2008
Modern combination drug therapy has substantially improved the clinical management of HIV-1 infection. Still, the emergence of drug-resistant variants eventually leads to therapy failure in most patients. The selection of an optimal follow-up regimen is complicated by an ever-increasing range of possible drug combinations.
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Modern combination drug therapy has substantially improved the clinical management of HIV-1 infection. Still, the emergence of drug-resistant variants eventually leads to therapy failure in most patients. The selection of an optimal follow-up regimen is complicated by an ever-increasing range of possible drug combinations.
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Synthesis and anti-HIV activity of arylpiperazinyl fluoroquinolones: A new class of anti-HIV agents
Bioorganic & Medicinal Chemistry Letters, 1999Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoroquinolones are reported. In the SAR study, the aryl substituents on the piperazine nitrogen were found to play an important role for the anti-HIV-1 activity. A few of the compounds exhibited potent anti-HIV activity: IC50=0.06 microM in chronically infected cells.
M, Hagihara +9 more
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Liposomes as nanocarriers for anti-HIV therapy
Drug Delivery and Translational Research, 2013Globally, in the last three decades of medical research, the use of liposomes as carrier for anti-HIV/AIDS drugs is gaining prominence. These potential anti-HIV nanocarriers are concentric lipid bilayers which can be fabricated to protect molecules and to target the drugs to specific sites, which is the reason behind their popularity in the ...
Shruti, Chopra +2 more
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2002
The use of targeted therapies to treat infectious diseases is a novel application that requires a persistent infection that cannot be cleared by other means and the expression of microbial antigens on the surface of productively-infected cells. Although some bacterial or parasitic infections may meet these criteria, chronic viral infections and microbe-
Seth H. Pincus +2 more
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The use of targeted therapies to treat infectious diseases is a novel application that requires a persistent infection that cannot be cleared by other means and the expression of microbial antigens on the surface of productively-infected cells. Although some bacterial or parasitic infections may meet these criteria, chronic viral infections and microbe-
Seth H. Pincus +2 more
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Bioinformatics-assisted anti-HIV therapy
Nature Reviews Microbiology, 2006Highly active antiretroviral therapy (HAART), in which three or more drugs are given in combination, has substantially improved the clinical management of HIV-1 infection. Still, the emergence of drug-resistant variants eventually leads to therapy failure in most patients.
Lengauer, T., Sing, T.
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