Results 331 to 340 of about 3,688,101 (379)

A Review on Quinoline Derived Scaffolds as Anti-HIV Agents.

Mini-Reviews in Medical Chemistry, 2019
After restricting the proliferation of CD4+T cells, Human Immunodeficiency Virus (HIV), infection persists at a very fast rate causing Acquired Immunodeficiency Syndrome (AIDS).
Nisha Chokkar, Sourav Kalra, M. Chauhan, Raj Kumar   +3 more
semanticscholar   +1 more source

Quinolone derivatives: Potential anti‐HIV agent—development and application

Archiv der Pharmazie, 2019
Acquired immune deficiency syndrome (AIDS)/human immunodeficiency virus (HIV) is one of the largest and most devastating public health pandemics throughout the world. The global pandemic of drug‐sensitive HIV and the increasing threat from drug‐resistant
Ruo Wang, Kai Xu, Weixiong Shi
semanticscholar   +1 more source

Emerging anti-HIV drugs

Expert Opinion on Emerging Drugs, 2005
There are now exactly 20 anti-HIV drugs licenced (approved) for clinical use, and > 30 anti-HIV compounds under (pre)clinical development. The licensed anti-HIV drugs fall into five categories: nucleoside reverse transcriptase inhibitors (NRTIs: zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir and emtricitabine); nucleotide reverse ...
openaire   +2 more sources

Towards anti-HIV vaccines

Vaccine, 1988
There is a great deal of experience on the development and testing of antiviral vaccines but, in the case of HIV, it will be necessary to analyse carefully our understanding of the biology of the organism, the natural history and pathology of the disease (in particular immunity or resistance to infection or clinical symptoms), the possible sources of ...
openaire   +2 more sources

Bioinformatics-assisted anti-HIV therapy

Nature Reviews Microbiology, 2006
Highly active antiretroviral therapy (HAART), in which three or more drugs are given in combination, has substantially improved the clinical management of HIV-1 infection. Still, the emergence of drug-resistant variants eventually leads to therapy failure in most patients.
Lengauer, T., Sing, T.
openaire   +3 more sources

Alloantigen-Stimulated Anti-HIV Activity

Blood, 1998
AbstractA number of studies have suggested that an immune response to human leukocyte antigen (HLA) alloantigens may contribute to protection against HIV infection. In the present study, we examined the effect of alloantigen-stimulated cell lines obtained from peripheral blood mononuclear cells (PBMC) of HIV-uninfected (HIV−) individuals and the ...
L A, Pinto, S, Sharpe, D I, Cohen, G M, Shearer   +3 more
openaire   +2 more sources

Boromycin, an Anti-HIV Antibiotic

Bioscience, Biotechnology, and Biochemistry, 1996
The polyether-macrolide antibiotic, boromycin, was isolated as a potent anti-human immunodeficiency virus (HIV) antibiotic from a fermentation broth of Streptomyces sp. A-3376. Boromycin was found to strongly inhibit the replication of the clinically isolated HIV-1 strain as well as the cultured strain in in vitro laboratory experiments.
J, Kohno, T, Kawahata, T, Otake, M, Morimoto, H, Mori, N, Ueba, M, Nishio, A, Kinumaki, S, Komatsubara, K, Kawashima   +9 more
openaire   +2 more sources

Naturally derived anti‐HIV agents

Phytotherapy Research, 2005
AbstractThe urgent need for new anti‐HIV/AIDS drugs is a global concern. In addition to obvious economical and commercial hurdles, HIV/AIDS patients are faced with multifarious difficulties associated with the currently approved anti‐HIV drugs. Adverse effects, the emergence of drug resistance and the narrow spectrum of activity have limited the ...
Asres, Kaleab, Seyoum, Ameha, Veeresham, Ciddi, Bucar, Franz, Gibbons, Simon   +4 more
openaire   +3 more sources

Pharmacogenetics of Anti-HIV Drugs

Annual Review of Pharmacology and Toxicology, 2008
Pharmacogenetics holds promise in HIV treatment because of the complexity and potential toxicity of multidrug therapies that are prescribed for long periods. Thus far, few candidate genes have been examined for a limited number of allelic variants, but a number of confirmed associations have already emerged.
A, Telenti, U M, Zanger
openaire   +2 more sources

Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma Lucidum

Phytochemistry, 1998
A new highly oxygenated triterpene named ganoderic acid alpha has been isolated from a methanol extract of the fruiting bodies of Ganoderma lucidum together with twelve known compounds. The structures of the isolated compounds were determined by spectroscopic means including 2D-NMR. Ganoderiol F and ganodermanontriol were found to be active as anti-HIV-
S, el-Mekkawy, M R, Meselhy, N, Nakamura, Y, Tezuka, M, Hattori, N, Kakiuchi, K, Shimotohno, T, Kawahata, T, Otake   +8 more
openaire   +2 more sources