Results 111 to 120 of about 150,878 (257)

The Effect of Natural Compounds on Cognitive Impairment Through BDNF/TrkB/CREB Pathway: A Review

Phytotherapy Research, EarlyView.
Natural compounds improve cognitive function by activating BDNF/TrkB/CREB signaling to reduce neuroinflammation, oxidative stress, apoptosis, and Aβ accumulation while promoting synaptogenesis. ABSTRACT Considering the global prevalence of Alzheimer's disease (AD) and the restrictions of current treatment procedures, natural compounds (such as curcumin,
Vahid Pourbarkhordar, Sohrab Rahmani, Hossein Hosseinzadeh, Soghra Mehri   +3 more
wiley   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Is It Political? Science Teachers' Perspectives on GSD‐Inclusive Science Teaching

Science Education, EarlyView.
ABSTRACT Teaching is often framed as neutral and apolitical, yet scholarship has long documented its entanglement with power, identity, and ideology. Despite growing attention to the sociopolitical dimensions of science education, less is known about what science teachers themselves understand as political and how those understandings shape where they ...
Gary W. Wright, Victoria Barron
wiley   +1 more source

The Mitigating Role of Managerial Ability in ESG Decoupling

Sustainable Development, EarlyView.
ABSTRACT Does managerial competence widen or bridge the gap between environmental, social, and governance (ESG) disclosures and actual performance? This paper explores the relationship between CEO ability and corporate decoupling regarding sustainability issues.
Isabel‐María García‐Sánchez, Rizwan Ali, Alejandra García‐Sánchez, Ramiz ur Rehman   +3 more
wiley   +1 more source

Synthesis, Characterisation, Biological Evaluation and In Silico Studies of Quinoline-1,2,3-Triazole-Anilines as Potential Antitubercular and Anti-HIV Agents. [PDF]

Molecules
Magwaza SS, Naidu D, Oyeneyin OE, Senzani S, Mkhwanazi NP, Tukulula M.   +5 more
europepmc   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Bird's eye view of natural products for the development of new anti-HIV agents: Understanding from a therapeutic viewpoint. [PDF]

Animal Model Exp Med
Al Amin M, Nafady MH, Zehravi M, Sweilam SH, Kumar KP, Akiful Haque M, Unnisa A, Singh LP, Sayeed M, Alshehri MA, Ahmad I, Emran TB, Uddin MZ.   +12 more
europepmc   +1 more source

Goffman's Tempting the Devil in Stigma: A Close Rereading of Goffman's “Subversive” Construct of “the Normals” Versus “the Stigmatized”

Symbolic Interaction, EarlyView.
This article engages in a close rereading of Stigma, relating it to Goffman's biography as a person who faced stigma. Exploring his biography helps us to recognize the ways Goffman applies stigma strategies in how he represents himself as the author in Stigma.
Thaddeus Müller
wiley   +1 more source

Design, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers as Potent Anti-HIV Agents. [PDF]

ACS Med Chem Lett, 2016
Lee WG, Chan AH, Spasov KA, Anderson KS, Jorgensen WL.   +4 more
europepmc   +1 more source

Strategies for enhancing sensitivity in lateral flow assays

VIEW, EarlyView.
Lateral flow assays (LFAs) are essential for cost‐effective, rapid point‐of‐care diagnostics. However, conventional colourimetric LFAs often lack the sensitivity required for low‐abundance biomarkers. This review evaluates six enhancement strategies: flow modulation, sample preconcentration, advanced reporters, chemical signal amplification, structural
Aylar Eslami Saed, Jacopo Giaretta, Syamak Farajikhah, Fariba Dehghani   +3 more
wiley   +1 more source