Results 131 to 140 of about 150,878 (257)

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

A single‐center prospective observational study evaluating the efficacy and safety of tirbanibulin 1% in actinic keratoses in immunosuppressed patients: the ESTIMATE study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Actinic keratoses (AKs) are common precursors to squamous cell carcinoma and pose a heightened risk in immunosuppressed patients, such as organ transplant recipients (OTRs). Patients and methods This prospective, monocentric, single‐arm observational study investigated the safety and efficacy of topical tirbanibulin 1% ointment in ...
Elisa Zavattaro, Federica Veronese, Vanessa Tarantino, Chiara Airoldi, Paola Savoia   +4 more
wiley   +1 more source

Psoriasis and Chronic Viral Infections (HIV, HBV, and HCV): Therapeutic Approach and Safety. [PDF]

Medicina (Kaunas)
Almeida-Silva G, Couto-Sousa D, Tribolet-Abreu I, Monteiro F, Ferreira J, Antunes J, Filipe P.   +6 more
europepmc   +1 more source

Associations between prior wasting malnutrition and indices of insulin secretion and sensitivity among six cohorts from Asia and Africa: The SAMPA study

Diabetic Medicine, EarlyView.
Abstract Aims The role of prior wasting malnutrition (PM) in determining insulin sensitivity and secretion in low‐ and middle‐income countries (LMICs) remains unclear. We investigated associations of insulin indices with PM and whether these were modified by current body mass index (BMI).
Sharon E. Cox, Sana Ahmed, Dixi Paglinawan Modoc, Riddhi Dasgupta, Christina Christoffersen, Molly Chisenga, Julius Patrick Ferrer, Ruth Frikke‐Schmidt, Rikke Krogh‐Madsen, Belinda Kweka, Nanette Lee, Evangelista Malindisa, Mizinga J. Tembo, Patrick Ngoya, Dorothea Nitsch, Daniel Faurholt‐Jepsen, George PrayGod, Geeta Trilok‐Kumar, Suzanne Filteau, James A. M. Shaw   +19 more
wiley   +1 more source

Revisiting trial design considerations to improve efficiency of HIV-1 vertical transmission prevention efficacy trials in infants. [PDF]

Clin Trials
Giganti MJ, Wu D, Ruel T, Abrams EJ, Yin DE.   +4 more
europepmc   +1 more source

Real‐world observational study evaluating metabolic and kidney outcomes in patients living with chronic kidney disease and type 2 diabetes mellitus with obesity prescribed tirzepatide

Diabetic Medicine, EarlyView.
Abstract Background Obesity and type 2 diabetes mellitus (T2DM) accelerate chronic kidney disease (CKD) progression. Tirzepatide, a dual glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonist, has demonstrated metabolic and potential renoprotective benefits in clinical trials.
Jack E. Carruthers, Xi Yan Ooi, Dawn Goodall, Jo Reed, Rachna Bedi, Adrian McGrath, Michelle Willicombe, Parizad Avari, Andrew H. Frankel   +8 more
wiley   +1 more source

1,2-Benzothiazine Derivatives as Anti-HIV and Anti-HCV Agents: Structure-Activity Relationships and Research Perspectives. [PDF]

Int J Mol Sci
Topolska I, Szczęśniak-Sięga BM.
europepmc   +1 more source

Charting the course of Sjögren's disease: A historical analysis of scientific progress

European Journal of Oral Sciences, EarlyView.
Abstract Sjögren's disease (SjD) bears the name of the Swedish ophthalmologist Henrik Sjögren. His 1933 doctoral thesis on keratoconjunctivitis sicca ignited interest, yet much remains under debate. SjD is an autoimmune disorder that primarily affects the exocrine glands, particularly the salivary and lacrimal glands, leading to a dryness of the eyes ...
Diego Ustárroz Cantali, Fabiola Reis de Oliveira, Denise Cantarelli Machado, Moisés Evandro Bauer   +3 more
wiley   +1 more source

The proportion of tuberculosis disease among adult patients receiving biologic agents at a tertiary centre in Kenya. [PDF]

EULAR Rheumatol Open
Marsa SH, Owuor FO, Shah J, Mutuma FR.
europepmc   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source