Results 141 to 150 of about 150,878 (257)

Human APOBEC3G suppresses homologous recombination and LIG4‐independent end joining in DNA double‐strand break repair

The FEBS Journal, EarlyView.
Chromosomal DNA double‐strand breaks (DSBs) are repaired by homologous recombination and nonhomologous end joining (NHEJ). Recent work has additionally established theta‐mediated end‐joining (TMEJ) as a mechanism for DSB joining. Cells lacking NHEJ and TMEJ can repair DSBs in a homology‐dependent manner.
Shinta Saito, Miori Murayama, Usaki Arai, Sekifumi Akatsu, Ami Yamamoto, Misaki Kadoguchi, Noritaka Adachi   +6 more
wiley   +1 more source

Engineering Protein-Based HIV Entry Inhibitors: Advances, Challenges, and Translational Strategies. [PDF]

Biomolecules
Kumariya R, Bewley CA.
europepmc   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Clinically Relevant Risk of Hepatitis B Virus Infection and Reactivation in People With HIV After Withdrawal of Anti-HBV-Active Antiretroviral Therapy in Japan. [PDF]

Open Forum Infect Dis
Adachi E, Okazaki A, Kanno Y, Koga M, Yotsuyanagi H.   +4 more
europepmc   +1 more source

The H19/miR‐760/BST2 regulatory axis sustains breast cancer tumorigenesis and metastasis

The FEBS Journal, EarlyView.
H19 and BST2 promote breast cancer aggressiveness through their reciprocal coregulation by miR‐760. Since both transcripts are targeted by miR‐760, overexpression of one sequesters the microRNA and relieves repression of the other: H19 raises BST2 levels, and BST2 raises H19 levels.
Kekely Klouyovo, Evodie Peperstraete, Léa Mabille, Joséphine Louvieaux, Jim Marmuse, Clément Lecerf, Chann Lagadec, Xuefen Le Bourhis, Éric Adriaenssens   +8 more
wiley   +1 more source

1,3,4-Oxadiazole-sulfonamide hybrids: recent advances in biological activities, structure-activity relationships, and therapeutic applications. [PDF]

RSC Adv
Hosney A, Abdelhafez EMN, Mohamed MFA.
europepmc   +1 more source

Shared Decision‐Making in Haemophilia Involves More Treatment Differentiators in 2026

Haemophilia, EarlyView.
ABSTRACT Introduction Shared decision‐making regarding treatment choice in haemophilia care has become increasingly more complex and essential due to the availability of several innovative therapeutics that are characterized by their own advantages and limitations, which need to be tailored to individual patient needs.
Quentin Van Thillo, Guy Young, Cedric Hermans   +2 more
wiley   +1 more source

Post-operative bilateral anterior uveitis: a rare case of ocular complication associated with anti-adhesion agent use in obstetric and gynaecologic surgery. [PDF]

J Surg Case Rep
Caroline I, Ardiani LS.
europepmc   +1 more source

Gaps in diabetes care among people living with HIV and hypertension in Botswana: A cross‐sectional analysis of the InterCARE study

HIV Medicine, EarlyView.
Abstract Objectives Data on diabetes screening and monitoring, within HIV care programmes in sub‐Saharan Africa, remain limited. This study describes the quality of diabetes screening and management among people living with HIV with comorbid hypertension receiving care at facilities participating in the InterCARE trial in Botswana. Methods We conducted
Onkabetse Julia Molefe‐Baikai, Tshepo B. Leeme, Moagedi K. Mawi, Kago Kebotsamang, Thato Moshomo, Edwin Mogaetsho, Tendani Gaolathe, Kesaobaka Molebatsi, Matlhogonolo Kelepile, Keonayang Kgotlaetsile, Pooja Gala, Duolao Wang, Shabbar Jaffar, Laura M. Bogart, Lisa R. Hirschhorn, Mosepele Mosepele   +15 more
wiley   +1 more source

Macrophage polarization drives viral reservoirs in HIV-1 infection. [PDF]

Front Immunol
Glokpon AEC, Gbenoudon SJ, Abana CZ, Nartey PA, Klutse J, Lamptey H, Bonney EY, Kyei GB.   +7 more
europepmc   +1 more source