Results 71 to 80 of about 241,196 (260)
Chemistry – A European Journal, EarlyView.Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier +7 more
wiley +1 more source
Background brief on the prevention benefits of HIV treatment [PDF]
The advent in 1996 of potent combination antiretroviral therapy (ART), sometimes called HAART (highly active antiretroviral therapy) or cART (effective combination antiretroviral therapy), changed the course of the HIV epidemic.
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Clinical Pharmacology &Therapeutics, EarlyView.Canada's 2009 risk management plan (RMP) framework has not been evaluated for prenatal exposure impact. Conversely, widely used drugs such as nonsteroidal anti‐inflammatory drugs (NSAIDs) lack RMPs. We assessed first‐trimester exposure to RMP‐regulated medications following regulatory interventions and to NSAIDs following safety publications.
Nahiyan Saiyara Khan +4 more
wiley +1 more source
Electrochemical Three‐Component Synthesis of Heteroaryl Sulfonates
European Journal of Organic Chemistry, EarlyView.An electrochemical, metal‐free three‐component strategy for direct C(sp2)─H sulfonation of electron‐rich heteroarenes using SO2 and alcohols is described. Utilizing inexpensive graphite electrodes and practical SO2 stock solutions under mild conditions, this method provides straightforward access to heteroaryl sulfonates from simple building blocks ...
Po‐Chung Chien +2 more
wiley +1 more source
Start talking. Stop HIV : a campaign encouraging gay and bisexual men to talk openly about HIV [PDF]
CDC\u2019s Start Talking. Stop HIV. Campaign Materials\u2014brochurestsh_brochurePublication date from document properties.PrEP 101 -- PrEP access -- Is PrEP right for ...
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Electron, EarlyView.Physics‐driven advances in optical nanobiosensors for rapid, miniaturized, and point‐of‐care diagnostics for next‐generation decentralized and personalized healthcare based on sensor intelligence. ABSTRACT Public health emergencies and the escalating burden of chronic diseases necessitate a paradigm shift from centralized laboratory testing to rapid ...
Vishal Chaudhary +5 more
wiley +1 more source
Targeted expression of the anti-HIV microbicide lectin griffithsin in maize and tobacco
, 2013 Includes abstract.Includes bibliographical references.Plants are emerging as cost friendly alternative production systems for a variety of pharmaceuticals. Numerous therapeutic proteins have been produced in plant systems (Giddings et al., 2000; Ma et al.
Stark, Hester Catharina (Therese)
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Exploration, EarlyView.There is no effective method to treat this virus and prevent its transmission. To address this, we have developed a nano‐silver‐selenium liquid dressing (AgSe@LD) by combining silver and selenium nanoparticles with commercial liquid dressings. This unique AgSe@LD formulation exhibits good adhesion, stability and toughness and demonstrates efficient ...
Wei Wang +15 more
wiley +1 more source
Ending HIV transmission : test, treat, and prevent [PDF]
About 38,000 new HIV infections still occur each year. The US Government recently proposed Ending the HIV Epidemic: A Plan for America to reduce HIV transmission. The goal is to reduce new HIV infections by 90% by 2030.
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