Results 51 to 60 of about 150,878 (257)

Tuberculosis-associated IRIS in a young non-HIV patient undergoing TNF-α blockade for ankylosis spondylitis: a rare case report from Italy

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
Patients receiving anti-TNF-α therapy are at increased risk of developing tuberculosis (TB). While immune reconstitution inflammatory syndrome (IRIS) is classically associated with HIV-infected individuals initiating antiretroviral therapy, it has also ...
Enrico Perugini, Laura Campogiani, Luigi Coppola, Federico Cecilia, Sara Ciarpaglini, Martina Leone, Manuel Scimeca, Amedeo Ferlosio, Vincenzo Malagnino, Marco Iannetta, Loredana Sarmati   +10 more
doaj   +1 more source

Seroprevalence of Hepatitis B, Hepatitis C and HIV in Intensive Care Unit Patients

Türk Yoğun Bakim Derneği Dergisi, 2015
Objective: Intensive care unit (ICU) personnel are at high risk for infectious agents during interventional procedures, surgical procedures, and processes such as injection.
Hakan Bayır, İsa Yıldız, Esra Koçoğlu, Adem Deniz Kurt, Hasan Koçoğlu   +4 more
doaj   +1 more source

Clinical use of anti-HIV agents

Folia Pharmacologica Japonica, 2007
現在の抗HIV療法は，カクテル療法と言われるように3剤以上の多剤併用で行うことが基本である．国内で承認されている抗HIV薬は，その作用機序から，逆転写酵素阻害薬とプロテアーゼ阻害薬に分類され，逆転写酵素阻害薬は更に，核酸系と非核酸系とに分かれる．一般的には，非核酸系逆転写酵素阻害薬か，または，プロテアーゼ阻害薬をキードラッグとして，それに，2剤の核酸系逆転写酵素阻害薬を組み合わせて投与する．それぞれの薬剤の作用機序，特性，副作用を認識し，相互作用を考慮しつつ，組み合わせて投与することとなる．副作用は，同じ作用機序の薬剤に一般的に見られるものと，薬剤特異的なものがあり，注意が必要である．既に承認されている抗HIV薬の組み合わせのみではコントロール不良な多剤耐性HIVを持つ症例もあり ...
openaire   +3 more sources

Marine Algae Metabolites as Promising Therapeutics for the Prevention and Treatment of HIV/AIDS

Metabolites, 2019
This review presents an analysis of works devoted to the anti-human immunodeficiency virus (HIV) activity of algae metabolites—sulfated polysaccharides (fucoidans, carrageenans), lectins, laminarans, and polyphenols.
Natalya N. Besednova, Tatyana N. Zvyagintseva, Tatyana A. Kuznetsova, Ilona D. Makarenkova, Tatyana P. Smolina, Ludmila N. Fedyanina, Sergey P. Kryzhanovsky, Tatyana S. Zaporozhets   +7 more
doaj   +1 more source

Higher risk of Long COVID among patients with autoimmune rheumatic diseases and immunomodulatory therapy: a retrospective cohort analysis of national US data.

Arthritis &Rheumatology, Accepted Article.
Background Little is known about the prevalence of and factors associated with Long COVID in patients with autoimmune rheumatic diseases (AIRDs). Methods We conducted a retrospective cohort study using data from the National Clinical Cohort Collaborative (N3C).
Namrata Singh, A. Jerrod Anzalone, Holland Stevenson, Londyn Robinson, Lesley E. Jackson, Sandra E. Safo, Zachary Butzin‐Dozier, Kaleb Michaud, Maria I. Danila, Jasvinder A. Singh, Rena C. Patel, on behalf of the National Clinical Cohort Collaborative (N3C) Consortium   +11 more
wiley   +1 more source

Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents

Nature Communications, 2017
Tuberculosis (TB) remains one of the world’s deadliest communicable diseases, novel anti-TB agents are urgently needed due to severe drug resistance and the co-epidemic of TB/HIV.
Junying Ma, Hongbo Huang, Yunchang Xie, Zhiyong Liu, Jin Zhao, Chunyan Zhang, Yanxi Jia, Yun Zhang, Hua Zhang, Tianyu Zhang, Jianhua Ju   +10 more
doaj   +1 more source

Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils

Biology Open, 2015
Semen harbors amyloid fibrils formed by proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2) that potently enhance HIV infectivity.
Laura M. Castellano, Rebecca M. Hammond, Veronica M. Holmes, Drew Weissman, James Shorter   +4 more
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Antihuman Immunodeficiency Virus Type 1 (HIV-1) Activity of Rare Earth Metal Complexes of 4-Hydroxycoumarins in Cell Culture

Bioinorganic Chemistry and Applications, 2006
The cerium Ce(III), lanthanum La(III), and neodymium Nd(III) complexes with 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one (warfarin) (W) and 3,3′-benzylidenebis[4-hydroxycoumarin] (1) were synthesized and studied for the first time for ...
Ilia Manolov, Sevda Raleva, Petya Genova, Alexey Savov, Liliana Froloshka, Daniela Dundarova, Radka Argirova   +6 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source