Results 61 to 70 of about 2,385,197 (304)

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients

BMC Nephrology, 2011
Background Human leukocyte antigen (HLA) alleles are associated with many autoimmune diseases, including anti-glomerular basement membrane (GBM) disease.
Zhou Xu-Jie, Xu Peng-Cheng, Yang Rui, Cui Zhao, Chen Min, Luo Huan, Zhao Ming-Hui   +6 more
doaj   +1 more source

Correlation of Anti-HLA IgA Alloantibodies and Fc Receptor Motives with Kidney Allograft Survival

Immuno, 2022
Immunoglobulin A (IgA) is the most abundant antibody isotype in humans and anti-HLA IgA was found in sera of transplant recipients. Focusing on patients awaiting kidney re-transplantation, we tested the impact of anti-HLA-class I/II IgA antibodies on ...
Marie-Luise Arnold, Ulrike Steffen, Michael Wiesener, Christian Bach, Bernd M. Spriewald, Monika Lindemann   +5 more
doaj   +1 more source

Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection [PDF]

, 2006
Cellular immune responses are an important correlate of hepatitis C virus (HCV) infection outcome. These responses are governed by the host's human leukocyte antigen (HLA) type, and HLA-restricted viral escape mutants are a critical aspect of this host ...
Cheng, Wendy, Battegay, Manuel, E. Freitas, Jeffrey, G., James, Ian, Park, Lawrence P, Swiss HIV Cohort Study,, G. Jeffrey, Battegay, M., Jeffrey, Gary, Weber, R., Chapman, R., S. Herrmann, Furrer, Hansjakob, Telenti, Amalio, Telenti, A., Lucas, M., M. Lucas, null null, I. James, Weber, Rainer, Freitas, Elizabeth, H. Furrer, Gaudieri, S., S. A. Mallal, Park, P., Freitas, E., Cheng, W., K. Pfafferott, S. Gaudieri, R. Weber, Naidoo, Kiloshni, A. Rauch, Pfafferott, K., Mallal, Simon A, L. P. Park, Rauch, A., A. Telenti, Pfafferott, Katja, R. Chapman, Lucas, Michaela, M. Battegay, Park, L.P., Herrmann, Susan, K. Naidoo, Furrer, H., Rauch, Andri, W. Cheng, Herrmann, S., Naidoo, K., Chapman, Russell, Mallal, S.A., James, I., Gaudieri, Silvana, Park, Lawrence P., Mallal, S. A., Mallal, Simon A., Park, L. P.   +57 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

HLA-B*44 is associated with a more than twentyfold increase in cyclic citrullinated peptide antibody serum level in Croatian patients with seropositive rheumatoid arthritis.

PLoS ONE
ObjectivesTo determine whether any of the HLA-A*, HLA-B* and HLA-DR* alleles in seropositive rheumatoid arthritis (RA) can be associated with the extreme serum levels of rheumatoid factor (RF) and cyclic citrullinated peptide antibodies (anti-CCP ...
Jure Aljinović, Darko Kero, Daniela Šošo, Marin Petrić, Daniela Marasović Krstulović, Dijana Perković, Esma Čečuk-Jeličić, Sonja Jaman, Dora Dujmović, Ivanka Marinović   +9 more
doaj   +1 more source

Anti-HLA antibodies in transplant patients.

, 2018
Anti-HLA antibodies were analyzed in kidney transplant patients before transplantation and at the end of follow-up by LABScreen® assays using Luminex xMAP technology.
Rebeca Alonso-Arias (5089019), Alejandra García-Torre (5089028), María Luisa Suárez-Fernández (5089022), Pablo Martínez-Camblor (295223), Marco Antonio Moro-García (5089013), Minerva Rodríguez (5089010), Marta Elena Álvarez-Argüelles (276222), María Iglesias-Escudero (5089016), Raquel Marcos-Fernández (5089025)   +8 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

COMPARISON OF DIFFERENT METHODS OF ANTI-HLA ANTIBODIES DETECTION IN DIAGNOSIS OF ANTIBODY-MEDIATED RENAL ALLOGRAFT REJECTION

Вестник трансплантологии и искусственных органов, 2016
Aim: to analyze the relationship between circulating anti-HLA antibodies (class-I and class-II), renal pathology and C4d deposition in cases of late acute and chronic antibody-mediated renal allograft rejection according to the method of antibodies ...
E. S. Ivanova, E. S. Stolyarevich, O. E. Gichkun, N. B. Bogdanova, F. S. Baranova, L. Yu. Artyukhina, N. A. Tomilina   +6 more
doaj   +1 more source

Humanization and characterization of the anti-HLA-DR antibody 1D10 [PDF]

International Journal of Cancer, 2001
1D10 is a previously described antibody that binds to cells from a majority of B-cell malignancies. The current studies were designed to further evaluate the antigen specificity of 1D10 and its potential as an immunotherapeutic agent. Studies with transfectants and immunoprecipitation demonstrated that 1D10 recognizes some, but not all, of the human ...
S A, Kostelny, B K, Link, J Y, Tso, M, Vasquez, B H, Jorgensen, H, Wang, W C, Hall, G J, Weiner   +7 more
openaire   +2 more sources