Results 81 to 90 of about 2,385,197 (304)

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Diversity in the HLA-I Recognition of HLA-F Monoclonal Antibodies: HLA-F or HLA-Ib Monospecific, HLA-E or HLA-G Bispecific Antibodies with or without HLA-Ia Reactivity

Antibodies
Previous investigators have used various anti-HLA-F monoclonal antibodies (mAbs) to demonstrate that the tissue distribution of HLA-F is highly restricted. Notably, these mAbs differed in their immunodiagnostic capabilities.
Mepur H. Ravindranath, Narendranath M. Ravindranath, Carly J. Amato-Menker, Fatiha El Hilali, Edward J. Filippone   +4 more
doaj   +1 more source

Anti-HLA I antibodies induce VEGF production by endothelial cells, which increases proliferation and paracellular permeability

, 2009
Anti-human leukocyte antigen class I (HLA I) antibodies were shown to activate several protein kinases in endothelial cells (ECs), which induces proliferation and cell survival.
Ligeti, Nathalie, Bieri, Jürg, Bieri, Michael, Mohacsi, Paul, Farkas, Anikò, Oroszlan, Melinda, Mohacsi P, Oroszlan M, Bieri J, Bieri M, Ligeti N, Farkas A, Nathalie Ligeti, Jürg Bieri, Melinda Oroszlan, Paul Mohacsi, Michael Bieri, Anikò Farkas   +17 more
core   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Validation of Anti-HLA Antibodies in Serum of Blood Transfused or Organ Transplanted Patients

Eurasian Journal of Medicine, 2019
Objective: The role of HLA molecules in innate immunity is well known. It has also been established that anti-HLA antibodies are produced by blood transfusion, multiparous women, previous transplantation, and autoimmune diseases.
Gönül Zişan Öncel, Nilnur Eyerci, Atilla Eroğlu, İbrahim Pirim   +3 more
doaj  

Association between circulating anti-HLA IgG antibodies and adverse events in heart transplant recipients

Вестник трансплантологии и искусственных органов
Objective: to study the relationship between circulating anti-HLA antibodies and the incidence of adverse events (death and retransplantation) and to evaluate the effectiveness of targeted therapies for graft dysfunction.Materials and methods.
A. Yu. Goncharova, Yu. A. Kachanova, N. N. Koloskova, O. E. Gichkun, A. O. Shevchenko   +4 more
doaj   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Frequency of class I anti-HLA alloantibodies in patients infected by HIV-1

Brazilian Archives of Biology and Technology, 2010
The aim of this study was to evaluate the presence of class I anti-HLA alloantibodies in patients infected by HIV-1 and relate it with the different clinical courses of the disease. Blood samples were collected in EDTA tubes from 145 individuals.
Elza Regina Manzolli Leite, Oswaldo Luiz Luz Lima, Fábio Renato Manzolli Leite, Paulo Inácio da Costa   +3 more
doaj   +1 more source

Anti‐HLA‐B7 / HLA‐B44 strong cross immunoreactivity observed in flow cytometry HLA‐B27 immunotyping

International audienceAbstract Cross reactivities are known for human leukocyte antigen inside HLA‐B7 related Cross‐Reactive Group (B7CREG). Some CE‐IVD flow‐cytometry kits use double monoclonal antibodies (mAb) to distinguish HLA‐B27 and HLA‐B7 but ...
Waeckel, Louis, Francois, Fabien, Lambert, Claude, Berger, Anne‐emmanuelle   +3 more
core   +1 more source

Impaired Intracellular Transport and Cell Surface Expression of Nonpolymorphic HLA-E [PDF]

, 1992
The assembly of the classical, polymorphic major histocompatibility complex class I molecules in the endoplasmic reticulum requires the presence of peptide ligands and ~2-microglobulin (~2m). Formation of this trimolecular complex is a prerequisite for e~
Kellermann, Josef, Johnson, Judith P., Matthias Ulbrecht, Ulbrecht, Matthias, Josef Kellermann, Judith P. Johnson, Weiss, Elisabeth H., Elisabeth H. Weiss   +7 more
core   +1 more source