Results 1 to 10 of about 65,007 (116)

IgE glycans promote anti-IgE IgG autoantibodies that facilitate IgE serum clearance via Fc Receptors [PDF]

Frontiers in Immunology, 2022
BackgroundRecent studies have shown that IgE glycosylation significantly impacts the ability of IgE to bind to its high-affinity receptor FcεRI and exert effector functions. We have recently demonstrated that immunizing mice with IgE in a complex with an
Kevin Plattner, Kevin Plattner, Zahra Gharailoo, Zahra Gharailoo, Simon Zinkhan, Simon Zinkhan, Paul Engeroff, Martin F. Bachmann, Martin F. Bachmann, Martin F. Bachmann, Monique Vogel, Monique Vogel   +11 more
doaj   +2 more sources

A Comparison of Natural and Therapeutic Anti-IgE Antibodies [PDF]

Antibodies
Immunoglobulin E (IgE) plays a critical role for the immune system, fighting against parasites, toxins, and cancer. However, when it reacts to allergens without proper regulation, it can cause allergic reactions, including anaphylaxis, through a process ...
Monique Vogel, Paul Engeroff
doaj   +2 more sources

Development and characterization of a unique anti‐IgE mouse monoclonal antibody cross‐reactive between human and canine IgE [PDF]

Immunity, Inflammation and Disease, 2021
Background The efficacy assessment of human anti‐IgE monoclonal antibodies (mAbs) in animal models before clinical trials is hampered due to the lack of cross‐reactivity of anti‐IgE mAbs between species.
Akiko Kumagai, Takuya Nara, Mizuho Uematsu, Yoko Kakinuma, Takashi Saito, Kenichi Masuda   +5 more
doaj   +2 more sources

IgG Autoantibodies Against IgE from Atopic Dermatitis Can Induce the Release of Cytokines and Proinflammatory Mediators from Basophils and Mast Cells

Frontiers in Immunology, 2022
IgE-mediated release of proinflammatory mediators and cytokines from basophils and mast cells is a central event in allergic disorders. Several groups of investigators have demonstrated the presence of autoantibodies against IgE and/or FcεRI in patients ...
Remo Poto, Remo Poto, Remo Poto, Isabella Quinti, Gianni Marone, Gianni Marone, Gianni Marone, Gianni Marone, Maurizio Taglialatela, Amato de Paulis, Amato de Paulis, Amato de Paulis, Vincenzo Casolaro, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi   +16 more
doaj   +1 more source

Prospective assessment of pre-existing and de novo anti-HLA IgE in kidney, liver, lung and heart transplantation

Frontiers in Immunology, 2023
IntroductionAntibody mediated rejection (ABMR) is a major factor limiting outcome after organ transplantation. Anti-HLA donor-specific antibodies (DSA) of the IgG isotype are mainly responsible for ABMR.
Jasmin Mucha, Ara Cho, Ara Cho, Anna Marianne Weijler, Moritz Muckenhuber, Amun Georg Hofmann, Markus Wahrmann, Andreas Heinzel, Birgit Linhart, Pia Gattinger, Rudolf Valenta, Rudolf Valenta, Gabriela Berlakovich, Andreas Zuckermann, Peter Jaksch, Rainer Oberbauer, Thomas Wekerle   +16 more
doaj   +1 more source

IgE mediated autoallergy against thyroid peroxidase--a novel pathomechanism of chronic spontaneous urticaria? [PDF]

PLoS ONE, 2011
BACKGROUND: Chronic spontaneous urticaria (csU), which is characterized by recurrent episodes of mast cell-driven wheal and flare-type skin reactions, is often associated with elevated total IgE levels and thyroid autoimmunity. We speculate that some csU
Sabine Altrichter, Hans-Jürgen Peter, Dina Pisarevskaja, Martin Metz, Peter Martus, Marcus Maurer   +5 more
doaj   +1 more source

ANTI IGE NA ASMA GRAVE ‘RELATO DE CASO’

Arquivos de Ciências da Saúde da UNIPAR, 2023
A asma grave é uma doença respiratória crônica que afeta as vias aéreas, provocando inflamação e estreitamento dos brônquios. Esse estreitamento pode dificultar a respiração e causar sintomas como tosse, falta de ar, chiado no peito e aperto no peito ...
Milena Trento Bonifácio, Bruno Debona Souto, Daniela Neves Rezende, Danilo Silva Aguiar, Lilian Gomes Rossi Sancanari, Mayara Stirma, Wanessa Cândida Queiroz Belfort   +6 more
doaj   +1 more source

Feasibility of plant-expression system for production of recombinant anti-human IgE: An alternative production platform for therapeutic monoclonal antibodies

Frontiers in Plant Science, 2022
Omalizumab, the anti-immunoglobulin IgE antibody is the only approved and available monoclonal antibody as an auxiliary medicament for the severe respiratory allergic reactions.
Oranicha Hanittinan, Oranicha Hanittinan, Kaewta Rattanapisit, Ashwini Malla, Kittipan Tharakhet, Kittipan Tharakhet, Chutitorn Ketloy, Chutitorn Ketloy, Eakachai Prompetchara, Eakachai Prompetchara, Waranyoo Phoolcharoen, Waranyoo Phoolcharoen   +11 more
doaj   +1 more source

A novel detection method for cross-linking of IgE-receptors by autoantibodies in chronic spontaneous urticaria

Allergology International, 2022
Background: Autoantibodies (AAbs) against immunoglobulin E (IgE) antibodies (Abs) and their high-affinity receptor alpha subunits (FcεRIα) are key factors in the elicitation of type IIb autoimmune chronic spontaneous urticaria (type IIb aiCSU).
Yuki Koga, Tomoharu Yokooji, Ryohei Ogino, Takanori Taogoshi, Shunsuke Takahagi, Kaori Ishii, Yuko Chinuki, Eishin Morita, Michihiro Hide, Hiroaki Matsuo   +9 more
doaj   +1 more source

Nível sérico de IgE total em alergia respiratória: estudo em pacientes com alto risco de infecção por helmintos Total IgE level in respiratory allergy: study of patients at high risk for helminthic infection

Jornal de Pediatria, 2006
OBJETIVO: Eosinofilia e elevação de IgE sérica são expressões de atopia, contudo há fatores intervenientes como, por exemplo, as parasitoses intestinais.
Décio Medeiros, Almerinda Rego Silva, José Angelo Rizzo, Maria Eugênia Motta, Francisca Hosana Bezerra de Oliveira, Emanuel Sávio Cavalcanti Sarinho   +5 more
doaj   +1 more source