Results 101 to 110 of about 9,467,496 (262)

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Anti-infective and anti-cancer properties of the Annona species: Their ethnomedicinal uses, alkaloid diversity, and pharmacological activities

, 2019
Annona species have been a valuable source of anti-infective and anticancer agents. However, only limited evaluations of their alkaloids have been carried out. This review collates and evaluates the biological data from extracts and purified isolates for
Paul Keller (19587565), Phurpa Wangchuk (2466397), Yuvita Damayanti (20234463), Ari Nugraha (20126673)   +3 more
core  

Anti-infective treatment of peri-implant mucositis: a randomised controlled clinical trial

, 2011
To compare the effectiveness of two anti-infective protocols for the treatment of peri-implant ...
Salvi, Giovanni E, Daniele Botticelli, Lang, Niklaus P, Andrea Mombelli, Niklaus P. Lang, Mombelli, A, Giovanni E. Salvi, Lang, NP, Botticelli, Daniele, Malcolm Faddy, HeitzMayfield, LJA, Heitz-Mayfield, Lisa, null null, Lisa J. A. Heitz-Mayfield, Faddy, M, Heitz-Mayfield, Lisa J A, Faddy, Malcolm, Salvi, GE, Lang, Niklaus, Mombelli, Andrea, Botticelli, D, Salvi, Giovanni, Salvi, Giovanni Edoardo   +22 more
core   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Use of T Cell Mediated Immune Functional Assays for Adjustment of Immunosuppressive or Anti-infective Agents in Solid Organ Transplant Recipients:A Systematic Review

, 2020
Background: Defining the optimal dosage of the immunosuppressive or duration of anti-infective agents is a challenge in solid organ transplant (SOT) recipients.
Rasmussen, Allan, Sørensen, Søren Schwartz, Knudsen, Andreas Dehlbæk, Nielsen, Susanne Dam, Ostrowski, Sisse Rye, Gustafsson, Finn, Rezahosseini, Omid, Perch, Michael, Møller, Dina Leth, Omid Rezahosseini, Allan Rasmussen, Dina Leth Møller, Andreas Dehlbæk Knudsen, Sisse Rye Ostrowski, Michael Perch, Søren Schwartz Sørensen, Susanne Dam Nielsen, Finn Gustafsson   +17 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Importance of Relating Efficacy Measures to Unbound Drug Concentrations for Anti-Infective Agents [PDF]

, 2013
For the optimization of dosing regimens of anti-infective agents, it is imperative to have a good understanding of pharmacokinetics (PK) and pharmacodynamics (PD). Whenever possible, drug efficacy needs to be related to unbound concentrations at the site
Gonzalez, Daniel, Schmidt, Stephan, Derendorf, Hartmut   +2 more
core   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

Anti-infective potential of hydroalcoholic extract of Punica granatum peel against gram-negative bacterial pathogens

, 2018
Appendix A: Raw data pertaining to the paper entitled "Anti-infective potential of hydroalcoholic extract of Punica granatum peel against gram-negative bacterial pathogens.Appendix S: Supplementary (Extended) Data for above paper.
Pooja Patel (6089345), Chinmayi Joshi (6089348), Vijay Kothari (6093828)   +2 more
core   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source