Results 121 to 130 of about 9,467,496 (262)

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

SAR and Anti-Mycobacterial Activity of Quinolones and Triazoloquinolones: An Update

, 2013
Fluoroquinolones (FQ) are an important family of synthetic antimicrobial agents being clinically used over the past thirty years. Currently some FQ are under investigation for the treatment of multidrug-resistant tuberculosis (MDRTB), defined as ...
PIRISI, Maria Antonietta, CORONA, Paola, CARTA, Antonio, BRIGUGLIO, Irene, PIRAS, Sandra, Jabes D   +5 more
core  

Descripción de una nueva combinación de técnicas para el desbridamiento de heridas crónicas Description of a new combination of technics for the debridement of chronic wounds

Gerokomos, 2010
En el presente artículo presentamos la evolución clínica de una paciente con una lesión por presión estadio IV en el sacro. Describimos la utilización de una nueva pauta de desbridamiento mediante la combinación de un apósito de hidrofibra de ...
Antonio Erasto Villar Rojas, Álvaro Rafael Villar Hernández, María Díaz Mateos   +2 more
doaj  

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Anti-infective proteins in breast milk and asthma-associated phenotypes during early childhood

, 2014
Anti-infective proteins in breast milk and asthma-associated phenotypes during early ...
P Hartmann (13371840), MMH Kusel (14457858), PG Holt (14457411), G Zhang (7349387), CT Lai (10919022), PD Sly (14453628), WH Oddy (14449611)   +6 more
core  

Anti-infective management of infected skin ulcers [PDF]

Infected skin ulcers represent a frequent and intricate clinical challenge, necessitating prompt and comprehensive multidisciplinary interventions to avert complications. Anti-infective therapy constitutes a cornerstone in the therapeutic paradigm.
Luzzati, Roberto, Mearelli, Filippo, Di Bella, Stefano, Papola, Carmelo, Spazzapan, Luca, Nunnari, Alessio, D'Aleo, Francesco, Papa, Giovanni, Principe, Luigi   +8 more
core   +1 more source

Protocol for developing a core outcome set for traditional Chinese medicine in the treatment of pharyngitis

Frontiers in Medicine
BackgroundPharyngitis, a prevalent upper respiratory tract disorder, significantly impairs patients’ health-related quality of life due to persistent symptoms such as sore throat and dryness.
Danni Li, Danni Li, Chenyao Zhang, Chenyao Zhang, Boya Wei, Boya Wei, Yanjun Jin, Xinyao Jin, Xinyao Jin, Fengwen Yang, Fengwen Yang, Wentai Pang, Wentai Pang, Junhua Zhang, Junhua Zhang   +14 more
doaj   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source