Results 111 to 120 of about 1,757,314 (363)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Anti-inflammatory Activity of Azima tetracantha Root Bark Extract in Rats [PDF]

, 2023
R. Nagulsamy, L. Kalaiselvi, S. Preetha, Aravindh Babu R. Parthiban, S. Ramesh   +4 more
openalex   +1 more source

Honey anti-inflammatory factor identified [PDF]

, 2012
Four different brands of honey wound dressings are now on sale internationally as registered medical devices, all made from manuka honey because of its well-established reputation as an antibacterial agent.
Molan, Peter C.
core   +1 more source

Genome engineering of stem cells for autonomously regulated, closed-loop delivery of biologic drugs [PDF]

, 2017
Chronic inflammatory diseases such as arthritis are characterized by dysregulated responses to pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α).
Brunger, Jonathan M, Gersbach, Charles A, Guilak, Farshid, Willard, Vincent P, Zutshi, Ananya   +4 more
core   +3 more sources

Synthesis and Anti-Inflammatory Activity of (Z)-4-(2-(3-Oxopiperazin-2-ylidene)acetyl)benzoic Acid

Molbank
Non-steroidal anti-inflammatory drugs (NSAIDs) are an important class of medications; however, they have some drawbacks. We are developing a new NSAID with pronounced anti-inflammatory and analgesic activities and a very low toxicity—(Z)-3-(2-oxo-2-(p ...
Maksim V. Dmitriev, Ekaterina E. Khramtsova, Danila Y. Apuskin, Alexander I. Andreev, Ilya I. Kovalenko, Irina V. Mashevskaya, Andrey N. Maslivets   +6 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Synthesis and biological activity of a new class of antitumor cyclopeptides based on the solomonamides [PDF]

, 2018
Solomonamides A (1) and B (2) are novel natural products recently isolated from the marine sponge Theonella swinhoei [1]. Preliminary structural studies revealed an unprecedented cyclic peptide type structure.
Carrillo, Paloma, Cheng-Sánchez, Iván, Martínez-Poveda, Beatriz, Medina, Miguel Ángel, Quesada, Ana R., Sarabia-Garcia, Francisco Ramon   +5 more
core  

Design, synthesis, and biological evaluation of novel diclofenac analogs as promising anti-inflammatory agents

Indian Journal of Health Sciences and Biomedical Research KLEU, 2019
INTRODUCTION: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as analgesics and antipyretics in the treatment of pain, fever, and rheumatoid arthritis. Major side effect with treatment of NSAIDs is gastric irritation.
Manjula K Chikkamath, Girish A Hampannavar, Mahesh B Palkar   +2 more
doaj   +1 more source

Anti-inflammatory activity of

African Journal of Biotechnology, 2011
The anti-inflammatory activity of the chloroform, methanol and aqueous extracts of Wigandia urens and Acalypha alopecuroides were investigated on carrageenan-induced paw edema at doses of 400 mg/kg. The three extracts of W. urens, and the aqueous extract of A.
Zavala-Sánchez, MA, Pérez-González, C, Arias-García, L, Pérez-Gutiérrez, S   +3 more
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source