Encouraging physician appropriate prescribing of non-steroidal anti-inflammatory therapies: protocol of a randomized controlled trial [ISRCTN43532635] [PDF]
Background Traditional non-steroidal anti-inflammatory drugs (NSAIDs) are a widely used class of therapy in the treatment of chronic pain and inflammation.
Metge Colleen+7 more
doaj +4 more sources
Nitrogen Monoxide Releasing Nitric Ester Derivatives of Ibuprofen and Naproxen as COX Inhibitors, Anti-Inflammatory and Hypolipidemic Compounds [PDF]
Nitric esters are among the compounds that can liberate nitrogen monoxide (NO) in the organism. Due to the vasodilatation caused by nitrogen monoxide, NO-donors have been shown to protect endothelial function, acting as vasodilators, promoting efficient ...
Paraskevi Tziona+4 more
doaj +2 more sources
Desensitization for the prevention of drug hypersensitivity reactions [PDF]
Drug desensitization is the temporary induction of tolerance to a sensitized drug by administering slow increments of the drug, starting from a very small amount to a full therapeutic dose.
Sung-Yoon Kang+2 more
doaj +1 more source
New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory [PDF]
Purpose To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam).
Clóvis Ney Pinheiro Macêdo+6 more
doaj +1 more source
Analysis of the use and adverse effects of non-steroidal anti-inflammatory drugs: A pilot study [PDF]
Background/Aim. The use and adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs) in outpatients with rheumatic diseases has not yet been studied enough.
Perić Aneta, Toskić-Radojičić Marija
doaj +1 more source
Inflammation: What’s There and What’s New?
Since the dawn of man, inflammation has been known to humanity, as it is marked by pain. Inflammation processes are related to serious chronic diseases with irreversible damage to the organism, being crucial for the development of anti-inflammatory ...
Ricardo C. Calhelha+5 more
doaj +1 more source
Fused Triazole-Azepine Hybrids as Potential Non-Steroidal Antiinflammatory Agents
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the oldest and most widely used groups of drugs nowadays. However, the problem of searching for and creating new NSAIDs remains open, primarily due to the risks owing to their short- and long-term
Sergii Demchenko+6 more
doaj +1 more source
Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs [PDF]
Acute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP).
Tae Young Park+3 more
doaj +1 more source
Thrombosis Is Reduced by Inhibition of COX-1, but Unaffected by Inhibition of COX-2, in an Acute Model of Platelet Activation in the Mouse [PDF]
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
BB Dawood+43 more
core +8 more sources
Background/Aims: Previous studies have reported the protective effects of tauroursodeoxycholic acid (TUDCA) on gastric epithelial cells in some animal models, but the precise mechanisms are unclear.
Su Hwan Kim+10 more
doaj +1 more source