Results 91 to 100 of about 13,455,088 (254)

A Modular Synthesis of C5‐Sulfenyl Thiazoles via an Intermolecular Pummerer Rearrangement: An Underexplored Scaffold for Medicinal Chemistry

Angewandte Chemie, EarlyView.
Modular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Joe L. Smy, Theo C. Webb, Barnaby W. Greenland, S. Mark Roe, John Spencer, Storm Hassell‐Hart   +5 more
wiley   +2 more sources

Update on Therapy for Non-Infectious Scleritis

Clinical Ophthalmology
Allison Richey,1 Victoria Sattarova,2 Laura J Kopplin,3 Karen R Armbrust1 1Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA; 2Department of Ophthalmology, Hennepin County Medical Center, Minneapolis, MN,
Richey A, Sattarova V, Kopplin LJ, Armbrust KR   +3 more
doaj  

Design and Synthesis of New Non-Steroidal Anti-inflammatory Agents with Expected Selectivity toward Cyclooxygenase-2 Inhibition

Iraqi Journal of Pharmaceutical Sciences, 2017
This study includes design and synthesis of new non-steroidal anti-inflammatory agents (NSAIDs) with expected cyclooxygenase-2 (COX-2) selective inhibition to achieve better activity and low gastric side effects.
Nadeem A. Abdul Razzak, Samera F.Hussan, Ahlam J. Qaseer   +2 more
doaj   +1 more source

The Impact of Differential Cost Sharing of Non-Steroidal Anti-Inflammatory Agents on the Use and Costs of Analgesic Drugs [PDF]

OBJECTIVE: To estimate the effect of differential cost sharing (DCS) schemes for non-steroidal anti-inflammatory drugs (NSAIDs) on drug subsidy program and beneficiary expenditures.
Bernie J. O'Brien, Anne M. Holbrook, Lisa R. Dolovich, Adrian R. Levy, Paul V. Grootendorst, John K. Marshall   +5 more
core  

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

Study on the Consumption of Non-Steroidal Anti-Inflammatory Drugs and Antibiotics by the Brazilian Adult Population: A Cohort Study

Pharmacy
Self-medication without a medical or dental prescription is an action that leads to a significant problems associated with the overuse of medication in Brazil.
Douglas Araujo Pedrolongo, Fernanda Teixeira Sagioneti, Giovana Maria Weckwerth, Gabriela Moraes Oliveira, Carlos Ferreira Santos, Adriana Maria Calvo   +5 more
doaj   +1 more source

Anti-inflammatory effect of Śirīṣāvaleha prepared by two liquid media on carrageenan induced rat paw oedema model

Ancient Science of Life, 2017
Background: Steroidal and non-steroidal anti-inflammatory agents have several limitations, due to which people are moving towards use of traditional medicines. Considering this, the current attempt is aimed to evaluate in vivo anti-inflammatory effect of
Harmeet Kaur, Galib Ruknuddin, Mukesh Nariya, Biswajyoti Patgiri, Prashant Bedarkar, Pradeep Kumar Prajapati   +5 more
doaj   +1 more source

TOIB Study. Are topical or oral ibuprofen equally effective for the treatment of chronic knee pain presenting in primary care: A randomised controlled trial with patient preference study. [ISRCTN79353052] [PDF]

, 2005
Background: Many older people have chronic knee pain. Both topical and oral non- steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat this.
Spencer, Anne E., Hennessy, Enid M., Cross Pamela L, Spencer, AE, Ashby Deborah, Harding, G, Enid M Hennessy, Anne E Spencer, Harding Geoff, Parsons Suzanne, Underwood, Martin, Letley Louise, Letley, Louise, Martin Underwood, Underwood Martin, TOIB Study Team, Louise Letley, Hennessy Enid M, Underwood, M, Hennessy, EM, Spencer Anne E, Ashby, D, Suzanne Parsons, null null, Cross, Pamela L., Pamela L Cross, Ashby, Deborah, Geoff Harding, Deborah Ashby, Cross, PL, Harding, Geoff, Parsons, Suzanne, Parsons, S, Letley, L   +33 more
core   +2 more sources

Inflammatory Signatures Beyond Th1/Th2 Endotypes Provide Insights Into Postoperative Recurrence in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate medical and surgical interventions highlights the need for improved characterization beyond the traditional type 2 and non‐type 2 phenotypes to better
Liyona Kampel, Narin N. Carmel, Shaun Edalati, Hen Chaushu, Forsan Jahshan, Yaniv Hadi, Timur Pestrikov, Leonor Leider Trejo, Nidal Muhanna, Avraham Abergel   +9 more
wiley   +1 more source