Results 81 to 90 of about 21,849 (255)

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Prophylaxis and treatment of non-steroidal anti-inflammatory drug-induced upper gastrointestinal side-effects [PDF]

, 2001
The use of specific agents to heal mucosal lesions or to prevent non-steroidal anti-inflammatory drug toxicity, has focused upon two approaches: replacement of prostaglandin deficiency and inhibition of acid secretion.
G. Bianchi Porro, M. Lazzaroni
core   +1 more source

Effectiveness of anti-inflammatory premedication on inferior alveolar nerve block success in acute irreversible pulpitis: a systematic review [PDF]

Exploration of Medicine
Background: Irreversible pulpitis is commonly associated with reduced success of inferior alveolar nerve block (IANB) during root canal treatment, often leading to inadequate intraoperative pain control.
Alessio Danilo Inchingolo, Grazia Marinelli, Lucia Pia Zaminga, Annarita Savino, Francesca Elena Dell’Anna, Francesco Inchingolo, Gianluca Martino Tartaglia, Massimo Del Fabbro, Andrea Palermo, Daniela Di Venere, Angelo Michele Inchingolo, Gianna Dipalma   +11 more
doaj   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

SOME CONTEMPORARY VIEWS ON NON-STEROIDAL ANTI-INFLAMMATORY DRUGS [PDF]

, 2001
Background. Non-steroidal anti-inflammatory drugs (NSAID) are important for the treatment of inflammation and pain. In equal doses these drugs provide more or less equal effects.
Nevenka Krčevski Škvarč, Marijan Ivanuša, Jasna Rozman Marčič   +2 more
core  

Optical Windows for Transcranial Brain Imaging in Living Mice: Skull Thinning, Clearing, and Beyond

Advanced Science, EarlyView.
Longitudinal, noninvasive in vivo imaging is crucial for studying brain physiology. Advances in transcranial optical windows and multiphoton microscopy have improved imaging depth, but their performance often deteriorates over time. This work investigated various transcranial window approaches and found that skull regrowth limits image quality.
Yiming Fu, Gewei Yan, Zhentao She, Yingzhu He, Kangqi Liu, Jianan Qu   +5 more
wiley   +1 more source

Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity [PDF]

, 2016
Novel amides of non steroidal anti-inflammatory drugs (NSAIDs), α-lipoic acid and indole-3-acetic acid with thiomorpholine were synthesised by a simple method and at high yields (60–92%).
Kourti, Malamati, Theodosis-Nobelos, Panagiotis, Gavalas, Antonios, Rekka, Eleni A.   +3 more
core   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Cancer recording and mortality in the General Practice Research Database and linked cancer registries. [PDF]

, 2013
PURPOSE: Large electronic datasets are increasingly being used to evaluate healthcare delivery. The aim of this study was to compare information held by cancer registries with that of the General Practice Research Database (GPRD).
Van Staa, Tjeerd; id_orcid, Richards, Mike A, Boggon, Rachael, Gallagher, Arlene M, Hammad, Tarek A, Rachael Boggon, Mike A. Richards, Chapman, Michael, Michael Chapman, Tarek A. Hammad, Arlene M. Gallagher, van Staa, Tjeerd P, Tjeerd P. van Staa   +12 more
core   +1 more source