Results 61 to 70 of about 13,455,088 (254)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

open access: yesAdvanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang   +6 more
wiley   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

open access: yesAdvanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han   +16 more
wiley   +1 more source

Effectiveness of anti-inflammatory premedication on inferior alveolar nerve block success in acute irreversible pulpitis: a systematic review [PDF]

open access: yesExploration of Medicine
Background: Irreversible pulpitis is commonly associated with reduced success of inferior alveolar nerve block (IANB) during root canal treatment, often leading to inadequate intraoperative pain control.
Alessio Danilo Inchingolo   +11 more
doaj   +1 more source

Preoperatively administered single dose of dexketoprofen decreases pain intensity on the first 5 days after craniotomy: A single-centre placebo-controlled, randomized trial

open access: yesTranslational Neuroscience, 2023
Headache attributed to craniotomy is an underestimated and under-treated condition. Previous studies confirmed the efficacy of preemptive analgesia with non-steroidal anti-inflammatory agents.
Simon Éva   +8 more
doaj   +1 more source

The Use of Non-steroidal Anti-inflammatory Drugs, and Analgesics, Antipyretics and Anaesthetics at Ohu University Dental Hospital during the Years 2000 through 2003 [PDF]

open access: yes, 2005
P(論文)We studied the type, quantity and circumstances of non-steroidal anti-inflammatory drugs, and analgesics, antipyretics and anaesthetics medications at the Hospital of the Ohu University School of Dentistry during the years 2000 through 2003.
浜田, 節男   +11 more
core  

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

open access: yesAdvanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon   +27 more
wiley   +1 more source

Musculoskeletal pain: determination of clinical phenotypes and the rational treatment approach

open access: yesAlʹmanah Kliničeskoj Mediciny, 2019
Personalized treatment is one of the basic principles of modern medicine. When administering a treatment, one should consider individual patient characteristics, comorbidities and, what is most important, the prevailing symptoms, as well as the clinical ...
A. E. Karateev
doaj   +1 more source

Non-steroidal anti-inflammatory drugs types.

open access: yes, 2019
Non-steroidal anti-inflammatory drugs types.
Alberto Villarejo-Galende (7392335)   +4 more
core   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

open access: yesAdvanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl   +20 more
wiley   +1 more source

Topical diclofenac: Clinical effectiveness and current uses in osteoarthritis of the knee and soft tissue injuries [PDF]

open access: yes, 2008
Background: Diclofenac is a commonly used non-steroidal anti-inflammatory drug (NSAID) for symptom control in osteoarthritis (OA) of the knee and soft tissue injuries.
Banning, M
core   +1 more source

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