Results 31 to 40 of about 857,317 (238)
Inhibitor of Apoptosis Proteins as Novel Targets in Inflammatory Processes [PDF]
, 2013 Objective: Inhibitor of apoptosis proteins (IAPs), such as X-linked or cellular IAP 1/2 (XIAP, cIAP1/2), are important regulators of apoptosis. IAP antagonists are currently under clinical investigation as anticancer agents.
Erhardt, Annette +10 more
core +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Vitamin A as an anti-inflammatory agent [PDF]
Proceedings of the Nutrition Society, 2002 Vitamin A is necessary for normal differentiation of epithelial tissues, the visual process and reproduction, and is vital for the optimal maintenance and functioning of the innate and adaptive immune system. Vitamin A deficiency is one of the most profuse nutritional deficiencies worldwide.
openaire +3 more sources
Hypoglycemic agents and potential anti-inflammatory activity [PDF]
, 2016 Current literature shows an association of diabetes and secondary complications with chronic inflammation. Evidence of these immunological changes include altered levels of cytokines and chemokines, changes in the numbers and activation states of various
John Galdo +2 more
core +2 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Immunoglobulin A as an anti-inflammatory agent [PDF]
Clinical & Experimental Immunology, 2014 Immunoglobulin A (Ig)A is a class of antibodies that shows the highest daily synthesis, at a concentration of approximately 2–3 mg/ml, and is the second most prevalent antibody in the serum after IgG 1. IgA is differentially distributed between the systemic and mucosal immune systems and plays a key role in immune protection.
openaire +3 more sources
Gastroscopic evaluation of anti-inflammatory agents [PDF]
BMJ, 1980 Gastroscopy was performed in 164 patients with rheumatoid arthritis (RA) and 85 with osteoarthritis (OA) to assess the effects of anti-inflammatory agents on the stomach. The main criterion for entry into the trial was the absence of active gastric lesions on pretreatment endoscopy.
I. Caruso, G. Bianchi Porro
openaire +3 more sources
Anti-inflammatory Activity Of Bawang Dayak (Eleutherine Bulbosa (Mill. Urb.))ethanol Bulb Extracts [PDF]
, 2018 Background: Inflammation is a normal process in response to injury, but causes problems for the patient, including the appearance of pain, swelling, or fever.
Nuryanto, M. K. (Muhammad) +1 more
core
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
Scanning for therapeutic targets within the cytokine network of idiopathic inflammatory myopathies [PDF]
, 2015 The idiopathic inflammatory myopathies (IIM) constitute a heterogeneous group of chronic disorders that include dermatomyositis (DM), polymyositis (PM), sporadic inclusion body myositis (IBM) and necrotizing autoimmune myopathy (NAM).
De Paepe, Boel, Zschüntzsch, Jana
core +3 more sources