Results 221 to 230 of about 5,156 (280)

The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging

open access: yesAging Cell, EarlyView.
Human aging shows puzzling diversity: similar aging rates yet vastly different health outcomes. Our study of ~17,500 people revealed a health‐promoting trait (more common in women) linked to strong immune resilience and high expression of TCF7, a key immune gene. This trait enables individuals to fight infections like COVID‐19 more effectively, respond
Muthu Saravanan Manoharan   +176 more
wiley   +1 more source

A Comprehensive Multiomics Signature of Doxorubicin‐Induced Cellular Senescence in the Postmenopausal Human Ovary

open access: yesAging Cell, EarlyView.
Explants of human postmenopausal ovarian cortex and medulla were treated with doxorubicin for 24 h followed by culture for up to 10 days in doxorubicin‐free medium. Single nuclei sequencing and proteomics revealed an unbiased signature of ovarian senescence driven by epithelial cells in the cortex and stromal cells in the cortex and medulla ...
Pooja Raj Devrukhkar   +18 more
wiley   +1 more source

Senescence Cell Induction Methods Display Diverse Metabolic Reprogramming and Reveal an Underpinning Serine/Taurine Reductive Metabolic Phenotype

open access: yesAging Cell, EarlyView.
This study reveals that in vitro senescence induction methods significantly influence intracellular biomolecular profiles, showing both shared and unique metabolic responses. A novel bioanalytical pipeline was developed to explore these subphenotypes, highlighting the importance of targeting metabolic redox circuits and serine/taurine pathways for ...
Domenica Berardi   +11 more
wiley   +1 more source

MskAge—An Epigenetic Biomarker of Musculoskeletal Age Derived From a Genetic Algorithm Islands Model

open access: yesAging Cell, EarlyView.
Created in BioRender. Laird, E. (2025) https://BioRender.com/bqfajrn. ABSTRACT Age is a significant risk factor for functional decline and disease of the musculoskeletal system, yet few biomarkers exist to facilitate ageing research in musculoskeletal tissues. Multivariate models based on DNA methylation, termed epigenetic clocks, have shown promise as
Daniel C. Green   +8 more
wiley   +1 more source

Jamming and anti-jamming solutions for 5G and IoT

open access: hybrid
Fidelis Obukohwo Aghware   +1 more
openalex   +2 more sources

The International Scientific Forum on Alcohol Research (ISFAR) critiques of alcohol research: Promoting health benefits and downplaying harms

open access: yesAddiction, EarlyView.
Abstract Background and Aims The International Scientific Forum on Alcohol Research (ISFAR), many of whose members are linked to the alcohol industry, has published over 280 critiques on alcohol and health research. This study investigated whether ISFAR critiques favour studies reporting alcohol's health benefits while being more critical of those ...
James M. Clay   +7 more
wiley   +1 more source

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