Results 91 to 100 of about 52,218 (248)

Targeting Cannabinoid 1 Receptor in Macrophages Alleviates Psoriatic Skin Inflammation Through the AUF1–NLRP3 Axis

Advanced Science, EarlyView.
Macrophage CB1R emerges as a key driver of psoriatic inflammation by suppressing AUF1‐mediated post‐transcriptional control of NLRP3. CB1R inhibition restores AUF1‐dependent NLRP3 mRNA decay, restrains inflammasome activation, and alleviates psoriasis‐like inflammation.
Hongseo Choi, Sukyoung Han, Jinho Kim, Ji Hye Han, Eunsu Kim, Yeonjeong Heo, Minju Lee, Jooyoung Lee, Heerim You, Soyoun Lee, Su‐Hee Han, Ilrok Yoon, Sung Anjeon, Hyerim Kang, Seungyeon Ryu, Hyun‐Ji Park, Eunha Kim, Chul Hwan Bang, Ji Hyun Lee, Josephine M. Egan, Jung‐Woong Kim, Eun Kyung Lee, Wook Kim   +22 more
wiley   +1 more source

Report of a Patient With Anti-Jo-1 Syndrome With Loss of Consciousness. [PDF]

J Acute Med, 2022
Chen C, Su YJ, Wong CH.
europepmc   +1 more source

Colossal Modulation of Mechanical Resonance with temperature in single‐Crystalline SrTiO3 Microbridges Integrated on Silicon

Advanced Electronic Materials, EarlyView.
The structural characteristics and resonant mechanical behavior of suspended microbridges comprised of single‐crystalline SrTiO3 that has been grown on silicon are presented. Due to differences in thermal expansion between the SrTiO3 and silicon, we find that the resonant frequencies of the microbridges are not only enhanced, but also hyper‐sensitive ...
Deepa Guragain, Laveeza Ahmad, Alexander A. Puretzky, Carson Hester, Zheng Hui Lim, Richard Le, Sundeep Mukherjee, Ye Cao, Joseph H. Ngai   +8 more
wiley   +1 more source

Antisynthetase syndrome presenting as interstitial lung disease: a case report

Journal of Medical Case Reports, 2019
Background Antisynthetase syndrome is a relatively uncommon entity, and can be easily missed if not specifically looked for in adults whose initial presentation is with interstitial lung disease. Its presentation with interstitial lung disease alters its
Aliena Badshah, Iqbal Haider, Shayan Pervez, Mohammad Humayun   +3 more
doaj   +1 more source

Compliant Footpads Enable Terrain‐Adaptive Hopping in a Monopedal Robot

Advanced Intelligent Systems, EarlyView.
A lightweight compliant footpad with embedded spines lets a monopedal hopping robot keep stable ground contact. It preserves stance‐phase dynamics and enables reliable hopping on rock, sand, and ice. Monopedal hopping robots offer exceptional mobility over discontinuous terrain but require consistent foot‐ground contact to maintain stance‐phase ...
Jeeraphat Owen Kledkruemas, Song Li, Songnan Bai, Pakpong Chirarattananon   +3 more
wiley   +1 more source

Using photovoice to understand community perceptions of firearm risks and protective factors among Asian Americans

American Journal of Community Psychology, EarlyView.
Abstract This study used photovoice methodology to explore Asian Americans' perspectives on the root causes and protective factors of firearm violence in their communities. Photovoice provided a participatory platform for community members to document lived experiences and identify priorities for change.
Tsu‐Yin Wu, Szu‐Hsien Chen, Xining Yang, Ken Resnicow, Hsing‐Fang Hsieh   +4 more
wiley   +1 more source

[Significance of anti-Jo-1 antibody's clinical stratification in idiopathic inflammatory myopathy and disease spectrum]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban, 2023
Li JC, Lai ZH, Shao M, Jin YB, Gao XJ, Zhang K, Hou J, Zhang YY, Li ZG, Li YH.   +9 more
europepmc   +1 more source

Final Analysis of the BRUIN Phase 1/2 Study Assessing the Safety and Efficacy of Pirtobrutinib Monotherapy in Patients With MCL

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib, a highly selective, non‐covalent Bruton tyrosine kinase inhibitor (BTKi) previously demonstrated durable efficacy and tolerable safety following covalent (c) BTKi therapy in heavily pretreated relapsed/refractory (R/R) mantle cell lymphoma (MCL).
Michael L. Wang, Jonathon B. Cohen, Nirav N. Shah, Wojciech Jurczak, Pier Luigi Zinzani, Chan Y. Cheah, Chaitra S. Ujjani, Youngil Koh, Won Seog Kim, Sunita D. Nasta, Ian Flinn, Benoit Tessoulin, Shuo Ma, Alvaro J. Alencar, David J. Lewis, Jennifer A. Woyach, Kami J. Maddocks, Krish Patel, Yucai Wang, Joanna M. Rhodes, Constantine S. Tam, John F. Seymour, Hirokazu Nagai, Julie M. Vose, Bita Fakhri, Marc S. Hoffmann, Francisco Hernandez‐Ilizaliturri, Andrew D. Zelenetz, Anita Kumar, Talha Munir, Donald E. Tsai, Paolo Abada, Minna Balbas, Jian Li, Denise Wang, Lindsey E. Roeker, Toby A. Eyre   +36 more
wiley   +1 more source

Expanded characterization of the valproic acid zebrafish larval model of autism spectrum disorder: Insights into dysregulation in the gut

Animal Models and Experimental Medicine, EarlyView.
Meticulous calculation of zebrafish‐equivalent therapeutic valproic acid (VPA) dosage maximized the translational value of the data. Hyposerotonergic tone underpinned an anxiety‐like outcome as a core symptom of autism spectrum disorder (ASD). Compartment‐specific dopaminergic and serotonergic dysregulation in the brain versus gut provided mechanistic ...
Lesha Pretorius, Johanna Adriana Coetzee, Alexio Pedro dos Santos, Carine Smith   +3 more
wiley   +1 more source

Age-dependent myositis-specific autoantibody profiles and CD8+ T-cell signatures in juvenile dermatomyositis

Immunological Medicine
Juvenile dermatomyositis (JDM) is an autoimmune myopathy with skin manifestations, yet biomarkers reflecting disease activity and organ involvement at presentation remain incompletely defined.
Sungyeon Park, Motoshi Sonoda, Nobutaka Harada, Shunichi Adachi, Keishiro Kinoshita, Yutaro Yada, Katsuhide Eguchi, Motoko Yamanaka, Yuki Ichimura, Naoko Okiyama, Masataka Ishimura, Shouichi Ohga   +11 more
doaj   +1 more source