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A case of antisynthetase syndrome [PDF]

Clinical Case Reports, 2020
Respiratory complaints alone or in association with musculoskeletal complaints can be the predominant presenting feature of antisynthetase syndrome. Therefore, antibodies to cellular antigens should be evaluated in such clinical settings.
Clio P. Mavragani, Haralampos M. Moutsopoulos   +1 more
doaj   +6 more sources

ANTISITETASE SYNDROME: SERIES OF CASES DIAGNOSED IN A COMARCAL HOSPITAL

Galicia Clínica
Introduction: The antisynthetase syndrome is a rare autoimmune disease that affects multiple organs. It typically presents with polymyositis, interstitial lung disease, and antisynthetase autoantibodies.
Ignacio Lasierra Lavilla, Julien Paola Caballero Castro, Mario Nicolás Albani Pérez, Juan Salas Jarque, Lidia Estopiñan Fortea, Ignacio Vallés Tormo   +5 more
doaj   +1 more source

Early predominant inflammatory myopathy in anti‐glycyl‐tRNA synthetase (EJ) antibody positive antisynthetase syndrome

Clinical Case Reports, 2021
It is important to consider antisynthetase syndrome in the differential diagnosis of patients presenting with weakness, respiratory distress, and a constellation of complaints spanning multiple organ systems, as this will change clinical management.
Robin Warner, Derrece Reid
doaj   +1 more source

Plasma Proteome Reflects Tissue Damage and Clinical Manifestations in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Tissue‐specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating clearance and recycling of tissue‐derived proteins.
Yue‐Bei Luo, Josefin Kenrick, Angeles S. Galindo‐Feria, Antonella Notarnicola, Ana Daniela Ulloa Navas, Irene Peralta‐Garcia, Orane Demuynck, Andrea Kemp, Valérie Leclair, Karin Lodin, Eveline Van Gompel, Lara Dani, Fabricio Espinosa‐Ortega, Maryam Dastmalchi, Leonid Padyukov, Charlotta Preger, María Bueno Álvez, Mathias Uhlén, Peter Nilsson, Fredrik Edfors, Lina‐Marcela Diaz‐Gallo, Elisa Pin, Ingrid E. Lundberg, Begum Horuluoglu   +23 more
wiley   +1 more source

Development of myasthenia gravis 8 years after interstitial lung disease associated with antisynthetase (anti‐EJ antibody) syndrome

Clinical Case Reports, 2017
Key Clinical Message Patients with antisynthetase‐positive interstitial lung disease (ILD) alone sometimes develop myositis during follow‐up, but myasthenia gravis (MG) overlapping on antisynthetase syndrome is unusual.
Takashi Ishiguro, Naho Kagiyama, Eriko Kawate, Kyuto Odashima, Yotaro Takaku, Kazuyoshi Kurashima, Noboru Takayanagi   +6 more
doaj   +1 more source

Expert Perspectives: Toward Treat‐to‐Target Management in Adult Idiopathic Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Treat‐to‐target has transformed the management of several rheumatic diseases through predefined therapeutic goals, structured disease assessment, and timely treatment adjustment. Despite major advances in the understanding and treatment of idiopathic inflammatory myopathies (IIM), a formal treat‐to‐target framework for adult IIM has not yet been ...
Shiri Keret, Nantakarn Pongtarakulpanit, Rohit Aggarwal   +2 more
wiley   +1 more source

Antisynthetase syndrome presenting as interstitial lung disease: a case report

Journal of Medical Case Reports, 2019
Background Antisynthetase syndrome is a relatively uncommon entity, and can be easily missed if not specifically looked for in adults whose initial presentation is with interstitial lung disease. Its presentation with interstitial lung disease alters its
Aliena Badshah, Iqbal Haider, Shayan Pervez, Mohammad Humayun   +3 more
doaj   +1 more source

Pregnancy in CTD‐interstitial lung disease: Current evidence, clinical challenges, and a proposed management algorithm

Rheumatology &Autoimmunity, EarlyView.
Summary of pregnancy management in CTD‐ILD across preconception, antenatal, and postpartum phases, emphasizing risk stratification and multidisciplinary care. 6MWT, 6‐min walk test; CTD‐ILD: connective tissue disease‐interstitial lung disease; DLCO, diffusion capacity of the lung for carbon monoxide; FVC, forced vital capacity; MDT, multidisciplinary ...
Khaled Aldhuaina, Ghaydaa Aldabie, Mohammad Abdulsalam, Ali Jawad   +3 more
wiley   +1 more source

New Onset of Dermatomyositis/Polymyositis during Anti-TNF-α Therapies: A Systematic Literature Review

The Scientific World Journal, 2014
We performed a systematic search of databases from 1990 to 2013 to identify articles concerning the new onset of dermatomyositis/polymyositis (DM/PM) in patients treated with anti-TNF-α therapy.
Alexandra Maria Giovanna Brunasso, Werner Aberer, Cesare Massone   +2 more
doaj   +1 more source

Diagnostic Pitfall: Mixed Connective Tissue Disease‐Associated Pulmonary Hypertension Presenting With Postpartum Right‐Sided Heart Failure in a 21‐Year‐Old—Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Mixed connective tissue disease is a multisystem autoimmune condition characterized by overlapping clinical and serological features related to anti‐U1‐RNP antibodies of at least two connective tissue diseases. It may present with myocarditis, pericarditis, pulmonary arterial hypertension, and, less commonly, heart failure.
Sai Santhosha Mrudula Alla, Moksh Sanjay Khetan, Deekshitha Alla, Sri Lakshmi Ganguru, Srinidhi Appala, Krithi Sree, Riva Jayesh Shah, Aryan Seth, Nishant Anand Rawtani, Mohammed Raihanuddin Aamir, Nyassiri Warai Emmanuel   +10 more
wiley   +1 more source