Results 1 to 10 of about 2,373 (163)

A multidisciplinary approach to the diagnosis of antisynthetase syndrome

Frontiers in Medicine, 2022
Antisynthetase syndrome is a subtype of idiopathic inflammatory myopathy, strongly associated with the presence of interstitial lung disease. Diagnosis is made by identifying myositis-specific antibodies directed against aminoacyl tRNA synthetase, and ...
Matthew Wells, Sughra Alawi, Kyaing Yi Mon Thin, Harsha Gunawardena, Harsha Gunawardena, Adrian R. Brown, Anthony Edey, John D. Pauling, John D. Pauling, Shaney L. Barratt, Huzaifa I. Adamali   +10 more
doaj   +7 more sources

A Rare Case Report of Antisynthetase Syndrome With Progressive Myopathy and Interstitial Lung Disease in a 38‐Year‐Old Male [PDF]

Clinical Case Reports
Antisynthetase syndrome is a rare autoimmune disorder characterized by a range of clinical features, most commonly associated with autoantibodies targeting aminoacyl‐tRNA synthetases.
Masab Ali, Muhammad Umair Tariq, Muhammad Hassan, Muhammad Husnain Ahmad, Amina Jamil   +4 more
doaj   +3 more sources

An Exploratory Analysis of Antibody Dynamics in Isolated Organ Involvement of Antisynthetase Syndrome: A Single-Center Experience. [PDF]

ACR Open Rheumatol
Objective To characterize longitudinal anti–aminoacyl–tRNA synthetase (anti‐ARS) antibody kinetics in antisynthetase syndrome (ASyS) with isolated organ involvement (IOI) and examine associations with clinical trajectories versus multiple organ involvement (MOI).
Suzuki T, Yamaji M, Harada H, Kawahata K.   +3 more
europepmc   +2 more sources

Hypereosinophilia Associated With Antisynthetase Syndrome With Anti-Ro52/PL12 Co-Positivity: An Unusual Presentation. [PDF]

Clin Case Rep
ABSTRACT Hypereosinophilia is uncommon in ASS and this presentation makes diagnosis more challenging. Anti‐PL12's role in the severity of ILD is controversial but its association with anti‐Ro52 seems to give a more serious disease phenotype. African ethnicity could be a negative prognostic factor, associated with lung disease severity.
Kapuczinski A, Léon M, Rossi C, Bondue B, Demeulenaere N.   +4 more
europepmc   +2 more sources

Antisynthetase Syndrome Mimicking Pulmonary Infection: A Diagnostic Lesson From County-Managed Hospital. [PDF]

Clin Case Rep
ABSTRACT Antisynthetase syndrome (ASS) is a rare chronic autoimmune disease classified as a distinct subtype of idiopathic inflammatory myopathy, characterized by the presence of anti–aminoacyl‐transfer RNA synthetase (anti‐ARS) antibodies. Typical clinical features include myositis, interstitial lung disease (ILD), arthritis, fever, mechanic's hands ...
Cheng J.
europepmc   +2 more sources

Efficacy and safety of telitacicept in patients with progressive interstitial lung disease associated with antisynthetase syndrome, rheumatoid arthritis, or Sjögren’s syndrome: a prospective observational study [PDF]

Respiratory Research
Background Interstitial lung disease (ILD) is a severe complication of antisynthetase syndrome, rheumatoid arthritis, and Sjögren’s syndrome, contributing significantly to patient mortality. Standard treatment options remain limited. This study evaluated
Xue Chen, MingFang Sun, Ying Zhou, Fei Xiao, MengShan Li, YanLong Yang, HuanZi Dai   +6 more
doaj   +2 more sources

Case Report: Anti-PL-12 Antisynthetase syndrome complicated by natural killer/T cell non-Hodgkin’s lymphoma [PDF]

Frontiers in Immunology
Antisynthetase syndrome (ASS) is a systemic autoimmune disorder classified as a subtype of the idiopathic inflammatory myopathies (IIM). The condition is defined by the presence of mutually exclusive autoantibodies directed against an aminoacyl-tRNA ...
Kun Li, Mei-E Liang, Yang Liu, Qian-Yu Guo, Ke Xu   +4 more
doaj   +2 more sources

Clinical profiles associated with rapidly progressive interstitial lung disease in antisynthetase syndrome: A multicentric cohort study (TYPASS study). [PDF]

J Intern Med
Abstract Objectives To assess factors associated with rapidly progressive interstitial lung disease (ILD) (RP‐ILD) at time of ILD diagnosis in a multicentric retrospective cohort study of antisynthetase syndrome (ASyS). We used a complementary unsupervised approach, hierarchical clustering, to delineate distinct phenotypes among ASyS patients with ILD.
Billotte M, Moulinet T, Meyer A, Camara H, Bolko L, Didier K, Dury S, Bonnotte B, Devilliers H, Bonniaud P, Beltramo G, Campagne J, Magy-Bertrand N, Chaudier A, Valentin S, Jaussaud R, Decker P.   +16 more
europepmc   +2 more sources

Reclassification of Seronegative Rheumatoid Arthritis as Anti-PL-12 Antisynthetase Syndrome with Interstitial Lung Disease and Joint Involvement–Case Report [PDF]

Reports
Background and Clinical Significance: Antisynthetase syndrome (ASyS) is a rare autoimmune entity defined by the presence of anti-aminoacyl-t ribonucleic acid (RNA) synthetase autoantibodies and classically associated with a triad of interstitial lung ...
Diana Elena Cosău, Alexandru Dan Costache, Irina Iuliana Costache Enache, Ionela Lăcrămioara Șerban, Luiza Andreea Petrariu, Cristina Pomîrleanu, Mara Russu, Vladia Lăpuște, Codrina Ancuța   +8 more
doaj   +2 more sources

Severe finger necrosis in antisynthetase syndrome with positive anti‐OJ antibodies [PDF]

Clinical Case Reports
Key Clinical Message In a patient with anti‐aminoacyl tRNA synthetase antibody and anti‐OJ antibody syndrome, interventions likes warming, prostaglandins, and antiplatelets failed. However, prednisolone pulse treatment rapidly halted disease progression.
Yugo Horiuchi, Kenichi Hashimoto, Ryochi Yoshida, Akinori Sekizawa, Akatsuki Kubota, Meiko Maeda, Tatsushi Toda, Yuji Tanaka   +7 more
doaj   +2 more sources