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A multidisciplinary approach to the diagnosis of antisynthetase syndrome [PDF]
Antisynthetase syndrome is a subtype of idiopathic inflammatory myopathy, strongly associated with the presence of interstitial lung disease. Diagnosis is made by identifying myositis-specific antibodies directed against aminoacyl tRNA synthetase, and ...
Matthew Wells +10 more
doaj +6 more sources
Syndrome in question: antisynthetase syndrome (anti-PL-7) [PDF]
: Antisynthetase syndrome is a rare autoimmune disease characterized by interstitial lung disease and/or inflammatory myositis, with positive antisynthetase antibodies (anti-Jo-1, anti-PL-7, anti-PL-12, ZO, OJ, anti-KE or KS).
Ana Cláudia Cavalcante Esposito +2 more
doaj +7 more sources
Nailfold videocapillaroscopy in antisynthetase syndrome [PDF]
A 57-year-old woman with a diagnosis of antisynthetase syndrome (ASSD) underwent a nailfold videocapillaroscopy (NVC) showing a scleroderma pattern. Alterations in capillary morphology have been reported in adults with inflammatory myositis (IM) but only
G. Cassone +6 more
doaj +8 more sources
Antisynthetase Syndrome with Severe Interstitial Lung Disease in Pregnancy
Antisynthetase syndrome is a rare multisystem autoimmune disorder which clinically manifests with myositis, arthritis, interstitial lung disease, Raynaud phenomenon, and skin hyperkeratosis. Lung involvement represents the most severe form of disease and
Catalina I. Dumitrascu +4 more
doaj +2 more sources
Objective: Antisynthetase syndrome is a condition that includes interstitial lung disease and inflammatory myositis in its definition. The interstitial lung disease of this syndrome can vary in severity and if not identified soon enough, can lead to ...
Michelle Cancel, M.D. +1 more
doaj +2 more sources
ANTISYNTHETASE SYNDROME IS THE MOST SEVERE SUBTYPE OF POLYMYOSITIS/DERMATOMYOSITIS:DESCRIPTION OF CASES [PDF]
Polymyositis (PM) and dermatomyositis (DM) are autoimmune skeletal muscle diseases of unknown etiology, which are referred to as systemic connective tissue diseases and united under the common term Tidiopathic inflammatory myopathiesy.
Olga Alekseyevna Antelava +5 more
doaj +2 more sources
Echocardiographic characteristics of patients with antisynthetase syndrome
Right ventricular (RV) dysfunction and pulmonary hypertension (PH) occurs in approximately one‐third of patients with interstitial lung disease (ILD) and is associated with reduced 6‐minute walk distance (6MWD), and increased hospitalizations and ...
Jaimie L. Bryan +11 more
doaj +3 more sources
Unusual presentation of antisynthetase syndrome: a case series and review of the literature
Background Antisynthetase syndrome is an inflammatory myopathy that is characterized by the presence of anti-aminoacyl-tRNA synthetase antibodies. Only 30% of those who suffer from the disease can be identified.
Juan Estrada-Maya +9 more
doaj +2 more sources
Antisynthetase syndrome: a case report [PDF]
The case is about a 48-year-old man with one week history of progressively worsening shortness of breath and reduced exercise tolerance. Laboratory investigations revealed raised ESR, creatine kinase (CK) and positive anti-aminoacyl-transfer RNA synthetase.
Mehwish Asif, Qureshi +3 more
openaire +3 more sources
No standardised and universal treatment is available for antisynthetase syndrome. In particular, there is an unmet need for a single efficient treatment acting on its various manifestations, including interstitial lung disease, myositis and polyarthritis.
Jean Dudler, Fleur Baumann Benvenuti
doaj +2 more sources

