Results 71 to 80 of about 1,465 (207)

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

ROS‐Responsive Wedelolactone Hydrogel Promotes Intervertebral Disc Repair by Disrupting the NF‐κB–LCN2 Inflammatory Feedback Loop

Advanced Science, Volume 13, Issue 14, 9 March 2026.
A mechanically robust, ROS‐responsive hydrogel is engineered to treat intervertebral disc degeneration by targeting the NF‐κB–LCN2 inflammatory feedback loop. By delivering wedelolactone specifically within oxidative niches, this system disrupts macrophage–disc cell crosstalk.
Zimei Wu, Yan Xu, Lang Qin, Zemin Ling, Yingjie Mai, Xiong Tian Guo, Jiajia Chen, Leping Yan, Lin Wang, Liming Bian, Fuxin Wei   +10 more
wiley   +1 more source

Design of a New Anti-Lock Braking System for Motorcycles [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2011
A new anti-lock braking system (ABS) for motorcycles is proposed in this study. It functions by processing the speed of the motorcycle tire in contact with the ground relative to the speed of the motorcycle itself and by calculating the slip ratio (λ) of
M. Shamsmohammadi, M Soheili, S. Nasiri, M. J. Rajabirad, M. Torabi, N. Javam   +5 more
doaj  

Regenerative Braking Control Strategy of Electric-Hydraulic Hybrid (EHH) Vehicle

Energies, 2017
A novel electric-hydraulic hybrid drivetrain incorporating a set of hydraulic systems is proposed for application in a pure electric vehicle. Models of the electric and hydraulic components are constructed.
Yang Yang, Chang Luo, Pengxi Li
doaj   +1 more source

Rapamycin Reduces Amyloid‐β Plaques and Improves Behavioral Performance in a Sex‐Dependent Manner in Mouse Models of Amyloidosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Rapamycin treatment reduced cerebral Aβ plaque burden, alleviated neuritic dystrophy, suppressed glial hyperactivation, and increased plaque‐associated microglial recruitment in amyloidosis mouse models, resulting in improved memory performance. Mechanistically, rapamycin enhanced microglial lysosomal degradation, facilitated lipid droplet clearance in
Shihui Guo, Weishan Fu, Yating Wang, Qi Liu, Jiaxin Li, Kai Guo, Hongsheng Zhang   +6 more
wiley   +1 more source

Predictive Performance of Anti-Lock Braking System with PID Controller Optimized by Gravitational Search Algorithm for a Quarter Car Model: Simulation Modeling and Control

Automotive Experiences
Anti-lock Braking Systems (ABS) are critical safety components in the passenger vehicles. The ABS prevents wheel lock-up during braking and maintains vehicle control.
Mohd Sabirin Rahmat, Fauzi Ahmad, Vimal Rau Aparow, Rizauddin Ramli, Sallehuddin Mohamed Haris, Mohd Anas Mohd Sabri, Mohd Anas Mohd Sabri, Meor Iqram Meor Ahmad, Mohd Muhyidin Mustafa   +8 more
doaj   +1 more source

Varying Charge Voltage in the Steps Control Method of ABS for In-Wheel Motors Driven Electric Vehicles Based on an Improved LQG Scheme

IEEE Access, 2018
This paper explores a coordinated control strategy of the anti-lock braking system (ABS) for in-wheel motors driven electric vehicles to recover more braking energy while satisfying the target of slip ratio control based on a newly varying charge voltage
Juncheng Wang, Ren He
doaj   +1 more source

Engineering a Tumor‐Targeted MgH2@Lip/PD‐L1 Nanoplatform for Synergistic Hydrogen Therapy and Immune Activation

Rare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu, Ming Deng, Tao Ge, Li Xu, Xinnan Xu, Kaiqi Jin   +5 more
wiley   +1 more source

Design and Implementation of Active Brake Pedal Simulator Integrating Force Feedback and Energy Optimization

World Electric Vehicle Journal
Brake pedals and wheel braking units are mechanically decoupled in brake-by-wire systems. This causes the driver to lose the familiar pedal feel. To address this issue, this paper designed an active braking pedal simulator based on the long-travel ...
Chunrong He, Xiaoxiang Gong, Hong Zhang, Huaiyue Zhang, Yu Liu, Haiquan Ye   +5 more
doaj   +1 more source

Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Stress during adolescence or adulthood affects the ability of the prefrontal cortex (PFC) to adaptively regulate stress. Maladaptive adult stress leads to PFC hypofunction and a hypodopaminergic state in the medial, affect‐related ventral tegmental area (VTA), resulting in amotivation.
Daniela L. Uliana, Anthony A. Grace
wiley   +1 more source