Results 101 to 110 of about 41,260 (220)

Comparative metabolomics reveals streptophenazines with anti-methicillin-resistant Staphylococcus aureus activity derived from Streptomyces albovinaceus strain WA10-1-8 isolated from Periplaneta americana

BMC Microbiology
Background Streptophenazines, a class of phenazine compounds with a variety of alkyl side chains and activity against methicillin-resistant Staphylococcus aureus (MRSA), are mainly derived from soil or marine microbial secondary metabolites. However, the
Liuchong Zhu, Dan Huang, Jinli Tan, Jiaxuan Huang, Ruyu Zhang, Jingyang Liao, Jie Wang, Xiaobao Jin   +7 more
doaj   +1 more source

Engineered surface strategies to manage dental implant‐related infections

Periodontology 2000, EarlyView.
Abstract When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant‐related infections—one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems.
João Gabriel S. Souza, Bruna E. Nagay, Rodrigo Martins, Martinna Bertolini, Jamil A. Shibli, Conrado Aparicio, Magda Feres, Valentim A. R. Barão   +7 more
wiley   +1 more source

Exploiting strong synergies between punicalagin and cefoperazone to combat methicillin-resistant Staphylococcus aureus infections

npj Biofilms and Microbiomes
Methicillin-resistant Staphylococcus aureus (MRSA) represents a serious public health threat. The effectiveness of existing antibiotics to treat MRSA infections is diminishing.
Fang Liu, Jiahao Ren, Peihua Zhang, Wenliang Sun, Wan Liu, Allen D. Smith, Robert W. Li, Haiyan Yang   +7 more
doaj   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Estimating the likelihood of hospitalists to repeatedly prescribe high rates of antibiotics

Antimicrobial Stewardship & Healthcare Epidemiology
Among 70 hospitalists across three facilities, 47% of high prescribers of broad-spectrum hospital-onset (BSHO) agents remained high in the subsequent period versus 24% for initially high prescribers of anti-MRSA agents.
Radhika Prakash Asrani, Samuel Parks, Chad Robichaux, K. Ashley Jones, Kristen Paciullo, Jesse T. Jacob, Shabir Hasan, Sujit Suchindran, Lucy S. Witt, Scott Fridkin   +9 more
doaj   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Diosmetin Alleviates MRSA-Induced Pneumonia in Mice by Inhibiting NLRP3 Inflammasome Activation and NF-κB Signaling Pathway

Pharmaceuticals
Background/Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is a multidrug-resistant pathogen that poses a major public health concern.
Chenxi Wu, Huiguo Xie, Xiaofei Liang, Lujie Yang, Zhengxiao Ren, Ping Wu, Yingying Zhang   +6 more
doaj   +1 more source

Linker and Head-Group Exploration of Anti-MRSA Triaromatic Pleuromutilins

Journal of Medicinal Chemistry
Based on hit 6, a triaromatic pleuromutilin (TAP) and potent bacterial protein synthesis inhibitor, we explored the chemical space surrounding its pharmacophore by synthesizing 45 new conjugates. Herein, the adenine head was exchanged for new heterocycles, and the benzyl linker exchanged for aniline-, ether-, amide-, and hydroxybenzyl linkages, with ...
Christoffer V. Heidtmann, Christian Ding Fisker, Sarah Løgstrup, Patrick G. Eriksen, Louise H. Storm, Kristian Stærk, Laust Moesgaard, Maria Pedersen, Martin J. Madsen, Ahmed Yusuf, Krista Urup, Iben S. Højgaard, Jayappragash Ramesh, Rasmus H. Pihlsbech, Caroline B. Sørensen, Tore L. Rønn, Alexander B. Larsen, Laurits R. Caspersen, Mathias Æ. Møller, Chris R. Sixhøj, Niels Frimodt-Møller, Janne K. Klitgaard, Thomas E. Andersen, Carsten U. Nielsen, Poul Nielsen   +24 more
openaire   +3 more sources

Active Free Radical Cold Atmosphere Plasma Promotes Healing of Diabetes Foot Ulcer: Mechanism and Challenge

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Background Diabetic foot ulcers (DFUs) have become an important cause of disability and death in patients with diabetes. Traditional therapies are prone to problems such as recurrence and drug resistance, which result in unsatisfactory healing effects for DFUs.
Yiran Wang, Junxiao Zhang, Jinting Yan, Wenhua Bi, Jinlong Ma   +4 more
wiley   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 220-249, September 2026.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source