Results 141 to 150 of about 44,692 (253)

Stimuli‐Responsive Crosslinked Chitosan/PVP/PEG Hydrogel Networks for Targeted Drug Delivery and Antimicrobial Performance

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT In this study, a unique pH‐sensitive PEG/C/PVA hydrogel based on chitosan (C), polyvinyl propylene (PVP) and polyethylenglycol (PEG) crosslinked with tetraethyl orthosilicate (TEOS) was fabricated. This PEG/C/PVA hydrogel was designed to deliver different drugs with distinct release profiles, including diclofenac sodium and ciprofloxacin, and ...
Danial Mazhar, Sumra Afzal, Safia Hassan, Zahid Imran, Shabana Mehreen   +4 more
wiley   +1 more source

Exploiting strong synergies between punicalagin and cefoperazone to combat methicillin-resistant Staphylococcus aureus infections

npj Biofilms and Microbiomes
Methicillin-resistant Staphylococcus aureus (MRSA) represents a serious public health threat. The effectiveness of existing antibiotics to treat MRSA infections is diminishing.
Fang Liu, Jiahao Ren, Peihua Zhang, Wenliang Sun, Wan Liu, Allen D. Smith, Robert W. Li, Haiyan Yang   +7 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Comparative metabolomics reveals streptophenazines with anti-methicillin-resistant Staphylococcus aureus activity derived from Streptomyces albovinaceus strain WA10-1-8 isolated from Periplaneta americana

BMC Microbiology
Background Streptophenazines, a class of phenazine compounds with a variety of alkyl side chains and activity against methicillin-resistant Staphylococcus aureus (MRSA), are mainly derived from soil or marine microbial secondary metabolites. However, the
Liuchong Zhu, Dan Huang, Jinli Tan, Jiaxuan Huang, Ruyu Zhang, Jingyang Liao, Jie Wang, Xiaobao Jin   +7 more
doaj   +1 more source

Estimating the likelihood of hospitalists to repeatedly prescribe high rates of antibiotics

Antimicrobial Stewardship & Healthcare Epidemiology
Among 70 hospitalists across three facilities, 47% of high prescribers of broad-spectrum hospital-onset (BSHO) agents remained high in the subsequent period versus 24% for initially high prescribers of anti-MRSA agents.
Radhika Prakash Asrani, Samuel Parks, Chad Robichaux, K. Ashley Jones, Kristen Paciullo, Jesse T. Jacob, Shabir Hasan, Sujit Suchindran, Lucy S. Witt, Scott Fridkin   +9 more
doaj   +1 more source

Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni, Patrick Belvitch, Steven M. Dudek, Eleftheria Letsiou   +3 more
wiley   +1 more source

Pharmacological and Phytochemical Insights Into Ficus benghalensis (Indian Banyan): Anti‐Inflammatory, Antioxidant, and Anticancer Potentials

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
The aim of this review is to critically evaluate the therapeutic potential of Ficus benghalensis L. by integrating ethnomedicinal knowledge with contemporary scientific evidence. The objectives are to summarize its phytochemical profile, analyze antioxidant, antimicrobial, antidiabetic, anti‐inflammatory, and anticancer activities, elucidate underlying
Zainab Ali, Farhang Hameed Awlqadr, Uswa Ali, Iffat Ullah, Muhammad Tayyab Arshad, Abdul Rauf, Humaira Parveen, Sayeed Mukhtar, Uzma Faridi, Md. Sakhawot Hossain   +9 more
wiley   +1 more source

Linker and Head-Group Exploration of Anti-MRSA Triaromatic Pleuromutilins

Journal of Medicinal Chemistry
Based on hit 6, a triaromatic pleuromutilin (TAP) and potent bacterial protein synthesis inhibitor, we explored the chemical space surrounding its pharmacophore by synthesizing 45 new conjugates. Herein, the adenine head was exchanged for new heterocycles, and the benzyl linker exchanged for aniline-, ether-, amide-, and hydroxybenzyl linkages, with ...
Christoffer V. Heidtmann, Christian Ding Fisker, Sarah Løgstrup, Patrick G. Eriksen, Louise H. Storm, Kristian Stærk, Laust Moesgaard, Maria Pedersen, Martin J. Madsen, Ahmed Yusuf, Krista Urup, Iben S. Højgaard, Jayappragash Ramesh, Rasmus H. Pihlsbech, Caroline B. Sørensen, Tore L. Rønn, Alexander B. Larsen, Laurits R. Caspersen, Mathias Æ. Møller, Chris R. Sixhøj, Niels Frimodt-Møller, Janne K. Klitgaard, Thomas E. Andersen, Carsten U. Nielsen, Poul Nielsen   +24 more
openaire   +3 more sources

Exploring the Nutraceutical Potential of Achillea millefolium L.: Phytochemical Composition, Biological Activities, and Industrial Applications

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Achillea millefolium Linn., commonly known as yarrow, is an extraordinary medicinal plant. A. millefolium has broad therapeutic potential due to its phytochemistry and essential oil composition. It possesses pharmacological properties, including antidiabetic, antioxidant, anti‐inflammatory, liver‐protective, antimicrobial, and gastroprotective effects,
Tooba Majeed, Muhammad Tauseef Sultan, Ahmad Mujtaba Noman, Hassan Raza, Hagar M. Mohamed, Nimra Anees, Muhammad Imran, Muzzamal Hussain, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Entessar Al Jbawi, Ehab M. Mostafa, Samy Selim, Ayman Salama, Mohamed A. Abdelgawad   +14 more
wiley   +1 more source

Ceragenin‐Loaded Tri‐Layered Skin Substitute Composed of Natural and Synthetic Biopolymers for Burn Wound Healing

Journal of Biomedical Materials Research Part A, Volume 114, Issue 6, June 2026.
ABSTRACT Burn wounds present significant clinical challenges due to high infection risk, delayed healing, and extensive tissue damage. The development of biomimetic skin substitutes capable of simultaneously supporting tissue regeneration and preventing infection remains a critical need in burn wound management. In this study, a novel ceragenin (CSA‐44)
Nawal Aljayyousi, Emel Tamahkar Irmak, Esra Karaca, Elif Tümay Özer, Oğuzhan Akgün, Ferda Arı, Aycan Yiğit Çınar, Çağla Bozkurt Güzel, Paul B. Savage, Bilgen Osman   +9 more
wiley   +1 more source