Results 71 to 80 of about 2,024,119 (265)

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

Antimicrobial activity and mechanism of anti-MRSA of phloroglucinol derivatives. [PDF]

Daru
In previous studies, authors have completed the total synthesis of several phloroglucinol natural products and synthesized a series of their derivatives, which were tested with good biological activities.To discover anti-MRSA lead compound and study their mechanism of action.Phloroglucinol derivatives were tested to investigate their activities against
Yang X, Gao X, Ou J, Chen G, Ye L.
europepmc   +3 more sources

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Porphyrin‐Based Porous Materials for Antibacterial Applications

Advanced Science, EarlyView.
Porphyrin‐based porous materials have excellent photophysical properties and tunable structures for high‐efficiency antibacterial therapy. This review comprehensively discusses the structural design strategies and synthetic pathways of the four main types of porphyrin‐based porous materials, summarizes their cross‐domain antimicrobial applications, and
Xiao‐Xue Liang, Xin Li, Ying Xiong, Xin Wang, Ying‐Wei Yang   +4 more
wiley   +1 more source

Evaluation of empirical anti-methicillin-resistant Staphylococcus aureus therapy in patients without gram-positive cocci clusters on Gram stain: a post hoc analysis of the GRACE-VAP trial

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: To evaluate the clinical and safety outcomes associated with withholding empirical anti-MRSA therapy in patients with ventilator-associated pneumonia (VAP) whose endotracheal aspirate Gram stain showed no gram-positive cocci in clusters ...
Shogo Shirota, Kazuma Yamakawa, Jumpei Yoshimura, Yoshinori Ohta, Yuriko Takeda, Kensuke Nakamura, Hideki Hashimoto, Kyohei Miyamoto, Takeshi Morimoto   +8 more
doaj   +1 more source

Evaluating the ototoxicity of an anti-MRSA peptide KR-12-a2

Brazilian Journal of Otorhinolaryngology, 2018
Methicillin-resistant staphylococcus aureus is an emerging problem for the treatment of chronic suppurative otitis media, and also for pediatric tympanostomy tube otorrhea. To date, there are no effective topical antibiotic drugs to treat methicillin-resistant staphylococcus aureus otorrhea.In this study, we evaluated the ototoxicity of topical KR-12 ...
Sung, Chung Man, Kim, Hong Chan, Cho, Yong Beom, Shin, Song Yub, Jang, Chul Ho   +4 more
openaire   +5 more sources

A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings

British Journal of Clinical Pharmacology, EarlyView.
Abstract Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying antibiotic consumption is an important part of AMS initiatives to achieve these objectives.
Marjan Kandimahforoujaki, Kiplin A. Patanwala, Jan‐Willem C. Alffenaar, Asad E. Patanwala   +3 more
wiley   +1 more source

Investigation on the antibacterial activity and molecular mechanism of rifamycin derivatives against methicillin-resistant Staphylococcus aureus

European Journal of Medicinal Chemistry Reports
Methicillin-resistant Staphylococcus aureus (MRSA) poses a severe clinical drug resistance challenge. Point mutations in RpoB, the core target of rifamycins, have caused widespread of MRSA, highlighting the urgent need for developing novel rifamycin ...
Feng Ye, Tengteng Che, Mingze Xu, Yanjiao Ding, Yanrong Shi, Bin liu, Yuliang Li   +6 more
doaj   +1 more source

The hospital ‘superbug’: social representations of MRSA [PDF]

, 2006
The so-called ‘hospital superbug’ methcillin resistant staphylococcus aureus (MRSA) became a topic of media and political concern from the middle of the 1990’s.
Joffe, H., Washer, P.
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