Results 61 to 70 of about 41,260 (220)

Investigation on the antibacterial activity and molecular mechanism of rifamycin derivatives against methicillin-resistant Staphylococcus aureus

European Journal of Medicinal Chemistry Reports
Methicillin-resistant Staphylococcus aureus (MRSA) poses a severe clinical drug resistance challenge. Point mutations in RpoB, the core target of rifamycins, have caused widespread of MRSA, highlighting the urgent need for developing novel rifamycin ...
Feng Ye, Tengteng Che, Mingze Xu, Yanjiao Ding, Yanrong Shi, Bin liu, Yuliang Li   +6 more
doaj   +1 more source

Actinomycetes Producing Anti-Methicillin Resistant Staphylococcus aureus from Soil Samples in Nakhon Si Thammarat

Walailak Journal of Science and Technology, 2011
A total of 64 different isolates of Actinomycetes were isolated from soil samples in Nakhon Si Thammarat. The anti-MRSA activity of Actinomycetes isolates was examined using agar plug and agar well diffusion methods.
Sumeth NAORUNGROTE, Warangkana CHUNGLOK, Monthon LERTCANAWANICHAKUL, Phuwadol BANGRAK   +3 more
doaj   +1 more source

Evaluating the ototoxicity of an anti-MRSA peptide KR-12-a2

Brazilian Journal of Otorhinolaryngology, 2018
Methicillin-resistant staphylococcus aureus is an emerging problem for the treatment of chronic suppurative otitis media, and also for pediatric tympanostomy tube otorrhea. To date, there are no effective topical antibiotic drugs to treat methicillin-resistant staphylococcus aureus otorrhea.In this study, we evaluated the ototoxicity of topical KR-12 ...
Sung, Chung Man, Kim, Hong Chan, Cho, Yong Beom, Shin, Song Yub, Jang, Chul Ho   +4 more
openaire   +5 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

Impact of an antimicrobial stewardship program on optimizing linezolid consumption and susceptibility in intensive care unit patients with methicillin-resistance staphylococcus aureus: a retrospective cohort study

BMC Infectious Diseases
Background The empirical use of linezolid as a first-line agent for Methicillin-Resistant Staphylococcus Aureus (MRSA) without a clear indication is of high concern.
Heba Swidan, Mayada Salama, Eman Saleh, Ayat Mohamed, Salma Tarek, Rahma Sweedy   +5 more
doaj   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

Hyperbranched poly‐L‐lysine surface‐engineered bioprosthetic heart valves with anti‐calcification, anti‐infection, and durability

BMEMat, EarlyView.
The challenges of bioprosthetic heart valves (BHV) with respect to calcification, infection, and poor durability are tackled by surface engineering of hyperbranched poly‐L‐lysine (HBPL), providing a translational solution to improve long‐term valve performance.
Pai Peng, Dongchao Qiu, Yongyuan Kang, Qiaoxuan Wang, Xuelong Wang, Boyana Parvanova, Miroslav Karabaliev, Changyou Gao   +7 more
wiley   +1 more source

Evaluation of arbekacin anti-MRSA agents for adult in Japan.

The Japanese journal of antibiotics, 2012
There are a limited number of reports that compare the clinical efficacy of anti-MRSA agents such as arbekacin (ABK), vancomycin (VCM), teicoplanin (TEIC) and linezolid (LZD). There is a tendency for these four agents to show variation in the inflammatory response parameters, in C-reactive protein (CRP) and in white blood cell count (WBC), depending on
HAMADA, YUKIHIRO, TAMURA, KAZUYOSHI, KOYAMA, IKUMI, SEKI, MEGUMI, YAGO, KAZUO, SUNAKAWA, KEISUKE, KUROYAMA, MASAKAZU   +6 more
openaire   +2 more sources