Results 41 to 50 of about 2,024,119 (265)
Molecular Details of Actinomycin D-Treated MRSA Revealed via High-Dimensional Data
Marine Drugs, 2022 Methicillin-resistant Staphylococcus aureus (MRSA) is highly concerning as a principal infection pathogen. The investigation of higher effective natural anti-MRSA agents from marine Streptomyces parvulus has led to the isolation of actinomycin D, that ...
Xuewei Xia +7 more
doaj +1 more source
Hard-Wired Habits: The Challenge of De-Prescribing Antibiotics in Critically Ill Patients with CAP
Antimicrobial Stewardship & Healthcare EpidemiologyBackground: Community acquired pneumonia (CAP) is a common and frequently serious infection. Guidelines recommend empiric anti-MRSA and/or anti-pseudomonal therapy in patients with severe CAP who have previously grown those organisms in the last year or ...
David Dickson, Marisa Holubar, David Ha
doaj +1 more source
International Journal of Infectious Diseases, 2018 Objectives: To determine the molecular characteristics and antimicrobial susceptibility of healthcare-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) in Zhejiang Province.
Dandan Wu +7 more
doaj +1 more source
Synthesis of (+)-Darwinolide, a Biofilm-Penetrating Anti-MRSA Agent
Angewandte Chemie International Edition, 2018 Darwinolide, a recently identified marine natural product from the Antarctic sponge Dendrilla membranosa, was shown to exhibit promising activity against the biofilm phase of methicillin-resistant Staphylococcus aureus. Its challenging tetracyclic rearranged spongian diterpenoid structure links a trimethylcyclohexyl subunit to a seven-membered core ...
Thomas Siemon +2 more
openaire +2 more sources
Total Synthesis of Anti‐MRSA Active Diorcinols and Analogues
Chemistry – A European Journal, 2020 AbstractDiorcinols and related prenylated diaryl ethers were reported to exhibit activity against methicillin‐resistant clinical isolates of Staphylococcus aureus (MRSA). Within these lines, we report the first total synthesis of diorcinol D, I, J, the proposed structure of verticilatin and recently isolated antibacterial diaryl ether by using an ...
G. Jacob Boehlich +6 more
openaire +2 more sources
Journal of Clinical and Translational ScienceOBJECTIVES/GOALS: The purpose of this work is to assess antibiotic prescribing for inpatients with community-acquired bacterial pneumonia (CABP) due to methicillin-resistant Staphylococcus aureus (MRSA) in the All of Us database.
Corbyn Gilmore, Christopher R Frei
doaj +1 more source
Fucoidan-loaded, neutrophil membrane-coated nanoparticles facilitate MRSA-accompanied wound healing
Materials & Design, 2023 Treatment of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds remains an important clinical challenge. Current treatments using vancomycin usually result in high side effects with low treatment efficacy because of strong drug toxicity ...
Jingyi Li +6 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma +13 more
wiley +1 more source
Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs [PDF]
Frontiers in Microbiology, 2018 Staphylococcus aureus résistant à la méthicilline (SARM) constitue une menace importante pour la santé car ils ont tendance à causer des infections graves dans les populations vulnérables et sont difficiles à traiter en raison d'une gamme limitée d'antibiotiques efficaces et de leur capacité à former un biofilm. Ces organismes étaient autrefois limités
Hefa Mangzira Kemung +17 more
openaire +3 more sources
Advanced Science, EarlyView.Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao +9 more
wiley +1 more source