Results 41 to 50 of about 44,692 (253)

Total Synthesis of Anti‐MRSA Active Diorcinols and Analogues

Chemistry – A European Journal, 2020
AbstractDiorcinols and related prenylated diaryl ethers were reported to exhibit activity against methicillin‐resistant clinical isolates of Staphylococcus aureus (MRSA). Within these lines, we report the first total synthesis of diorcinol D, I, J, the proposed structure of verticilatin and recently isolated antibacterial diaryl ether by using an ...
G. Jacob Boehlich, Jessica de Vries, Olivia Geismar, Mirja Gudzuhn, Wolfgang R. Streit, Sebastian G. Wicha, Nina Schützenmeister   +6 more
openaire   +2 more sources

Predominance of ST5-II-t311 clone among healthcare-associated methicillin-resistant Staphylococcus aureus isolates recovered from Zhejiang, China

International Journal of Infectious Diseases, 2018
Objectives: To determine the molecular characteristics and antimicrobial susceptibility of healthcare-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) in Zhejiang Province.
Dandan Wu, Zhengan Wang, Haiping Wang, Lu Sun, Yan Chen, Shujuan Ji, Keren Shi, Yunsong Yu   +7 more
doaj   +1 more source

297 Antibiotic prescribing for inpatients with community-acquired bacterial pneumonia (CABP) due to methicillin-resistant Staphylococcus aureus (MRSA) in the All of Us database: Are there differences by age, sex, race, and ethnicity?

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: The purpose of this work is to assess antibiotic prescribing for inpatients with community-acquired bacterial pneumonia (CABP) due to methicillin-resistant Staphylococcus aureus (MRSA) in the All of Us database.
Corbyn Gilmore, Christopher R Frei
doaj   +1 more source

Effects of Antibiotics Administration on the Incidence of Wound Infection in Percutaneous Dilatational Tracheostomy [PDF]

, 2014
The effect of antibiotics during the perioperative period of percutaneous dilatational tracheostomy (PDT) is still controversial. A total of 297 patients who underwent the PDT procedure were divided into 2 groups:those administered antibiotics ...
Hagioka, Shingo, Hagiya, Hideharu, Kusano, Nobuchika, Morimoto, Naoki, Naito, Hiromichi, Okahara, Shuji, Otsuka, Fumio   +6 more
core   +1 more source

In vitro synergism of magnolol and honokiol in combination with antibacterial agents against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) [PDF]

, 2015
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a problematic pathogen posing a serious therapeutic challenge in the clinic. It is often multidrug-resistant (MDR) to conventional classes of antibacterial agents and there is an urgent ...
Gen-Chun Wang, Guo-Ying Zuo, Jun Han, Xin-Juan Zhang, Yu-Qing Li   +4 more
core   +1 more source

Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs [PDF]

Frontiers in Microbiology, 2018
Staphylococcus aureus résistant à la méthicilline (SARM) constitue une menace importante pour la santé car ils ont tendance à causer des infections graves dans les populations vulnérables et sont difficiles à traiter en raison d'une gamme limitée d'antibiotiques efficaces et de leur capacité à former un biofilm. Ces organismes étaient autrefois limités
Hefa Mangzira Kemung, Hefa Mangzira Kemung, Loh Teng-Hern Tan, Loh Teng-Hern Tan, Loh Teng-Hern Tan, Tahir Mehmood Khan, Tahir Mehmood Khan, Tahir Mehmood Khan, Kok-Gan Chan, Kok-Gan Chan, Priyia Pusparajah, Bey-Hing Goh, Bey-Hing Goh, Bey-Hing Goh, Learn-Han Lee, Learn-Han Lee, Learn-Han Lee, Learn-Han Lee   +17 more
openaire   +3 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Beyond conventional antibiotics for the future treatment of methicillin-resistant Staphylococcus aureus infections: two novel alternatives. [PDF]

, 2012
The majority of antibiotics currently used to treat methicillin-resistant Staphylococus aureus (MRSA) infections target bacterial cell wall synthesis or protein synthesis. Only daptomycin has a novel mode of action.
Devocelle, Marc, Fitzgerald-Hughes, Deirdre, Humphreys, Hilary   +2 more
core   +1 more source

Synthesis of (+)-Darwinolide, a Biofilm-Penetrating Anti-MRSA Agent

Angewandte Chemie International Edition, 2018
AbstractDarwinolide, a recently identified marine natural product from the Antarctic sponge Dendrilla membranosa, was previously shown to exhibit promising activity against the biofilm phase of methicillin‐resistant Staphylococcus aureus. Its challenging tetracyclic rearranged spongian diterpenoid structure links a trimethylcyclohexyl subunit to a ...
Thomas Siemon, Simon Steinhauer, Mathias Christmann   +2 more
openaire   +2 more sources

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, EarlyView.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source