Significance of anti-neutrophil cytoplasmic antibodies in systemic sclerosis [PDF]
Arthritis Research & Therapy, 2019 Background Up to 12% of patients with systemic sclerosis (SSc) have anti-neutrophil cytoplasmic antibodies (ANCA). However, the majority of these patients do not manifest ANCA-associated vasculitis (AAV) and the significance of ANCA in these patients is ...
Jayne Moxey +12 more
doaj +9 more sources
Anti-neutrophil cytoplasmic antibodies in new-onset systemic lupus erythematosus [PDF]
Anais Brasileiros de Dermatologia, 2017 : Background: The clinical significance of anti-neutrophil cytoplasmic antibodies in patients with new-onset systemic lupus erythematosus, especially in systemic disease accompanied by interstitial lung disease remains to be elucidated.
Fang Su +5 more
doaj +3 more sources
Anti-neutrophil cytoplasmic antibodies and their clinical significance [PDF]
Clinical Rheumatology, 2018 Anti-neutrophil cytoplasmic antibodies (ANCA) are a group of autoantibodies that cause systemic vascular inflammation by binding to target antigens of neutrophils. These autoantibodies can be found in serum from patients with systemic small-vessel vasculitis and they are considered as a biomarker for ANCA-associated vasculitis (AAV).
Supaporn Suwanchote +9 more
semanticscholar +5 more sources
Neutrophil Extracellular Traps Contain Selected Antigens of Anti-Neutrophil Cytoplasmic Antibodies [PDF]
Front Immunol, 2017 Neutrophil extracellular traps (NETs) are chromatin filaments decorated with enzymes from neutrophil cytoplasmic granules. Anti-neutrophil cytoplasmic antibodies (ANCAs) bind to enzymes from neutrophil cytoplasmic granules and are biomarkers for the ...
R. Panda +8 more
semanticscholar +3 more sources
Targeting immune checkpoints in anti-neutrophil cytoplasmic antibodies associated vasculitis: the potential therapeutic targets in the future [PDF]
Front Immunol, 2023 Anti-neutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis (AAV) is a necrotizing vasculitis mainly involving small blood vessels. It is demonstrated that T cells are important in the pathogenesis of AAV, including regulatory T cells (Treg ...
Meng Pan +4 more
semanticscholar +2 more sources
Perinuclear Anti-Neutrophil Cytoplasmic Antibodies (pANCA) Impair Neutrophil Candidacidal Activity and Are Increased in the Cellular Fraction of Vaginal Samples from Women with Vulvovaginal Candidiasis [PDF]
J Fungi (Basel), 2020 Vulvovaginal candidiasis (VVC) is primarily caused by Candida albicans and affects 75% of childbearing age women. Although C. albicans can colonize asymptomatically, disease is associated with an increased Candida burden, a loss of epithelial tolerance ...
A. Ardizzoni +10 more
semanticscholar +2 more sources
Anti-Neutrophil Cytoplasmic Antibodies: To Care or Not to Care. [PDF]
Cureus, 2021 Anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis is a disease process with a wide range of presentations, from asymptomatic or minimally symptomatic disease with positive laboratory testing, to florid acute end-organ damage. Consensus has not been established as to the frequency and/or protocol by which ANCA testing should be ...
Shahid S, Alam SH, Gaber L, Ahmed S.
europepmc +5 more sources
Anti‐glycoprotein 2 (anti‐GP2) IgA and anti‐neutrophil cytoplasmic antibodies to serine proteinase 3 (PR3‐ANCA): antibodies to predict severe disease, poor survival and cholangiocarcinoma in primary sclerosing cholangitis [PDF]
Aliment Pharmacol Ther, 2020 Primary sclerosing cholangitis (PSC) is associated with progressive liver disease and cholangiocarcinoma. Although risk stratification is crucial for making clinical decisions, it is hindered by a scarcity of proven prognostic markers.
E. Wunsch +12 more
semanticscholar +2 more sources
Comparison of rituximab induction and maintenance regimens in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: PK/PD modelling of ANCA and gammaglobulin levels in real-world patientsResearch in context [PDF]
EBioMedicineSummary: Background: We aimed to provide pharmacokinetic-pharmacodynamic (PK/PD) rationale for selecting the optimal induction and maintenance dosing regimens in ANCA-associated vasculitis (AAV) using a population modelling approach based on PK, ANCA ...
Blaise Pasquiers +11 more
doaj +2 more sources
Lupus-like nephritis with positive anti-neutrophil cytoplasmic antibodies and negative antinuclear antibodies [PDF]
Brazilian Journal of Nephrology, 2020 Antineutrophil cytoplasmic antibodies (ANCAs) are associated with small vessel vasculitis but their prevalence is not rare in other immune diseases.
Joana Eugénio Santos +6 more
doaj +3 more sources