Results 121 to 130 of about 2,533,954 (307)

Anti-neutrophil cytoplasmic antibody

Anti neutrophil cytoplasmic antibodies (ANCAs) are autoantibodies directed against cytoplasmic constituents of neutrophils and monocytes, and they are closely linked with a spectrum of small vessel vasculitides collectively termed ANCA associated vasculitis (AAV).
openaire   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Myeloperoxidase and anti-MPO IgG synergistically enhance TLR9-mediated immune activation in ANCA-associated vasculitis

Cell Reports
Summary: Anti-neutrophil cytoplasmic antibodies (ANCAs) target antigens in neutrophil granules, such as myeloperoxidase (MPO) or proteinase 3, causing small-vessel inflammation.
Calvin Krollmann, Maria-Lourdes Saenz, Ruth-Miriam Koerber, Kevin Cieslak, Angela Rösen-Wolff, Peter Brossart, Valentin S. Schäfer, Natalio Garbi, Abraham Rutgers, Peter Heeringa, Lino L. Teichmann   +10 more
doaj   +1 more source

A Case of Simultaneous, Biopsy-Proven, Classic, ANCA-Positive Wegener's Granulomatosis and Anti-GBM Disease, but without Detectible Circulating Anti-GBM Antibodies

The Scientific World Journal, 2010
Wegener's granulomatosis (WG) is a systemic, necrotizing, granulomatous vasculitis of unknown etiology. Approximately 75% of cases present as classic WG with both pulmonary and renal involvement, while the remaining 25% of patients present with a limited
Aleksandra Gmurczyk, Shubhada N. Ahya, Robert Goldschmidt, George Kim, L. Tammy Ho, Kevin Nash   +5 more
doaj   +1 more source

Systemic vasculitis associated with anti neutrophil cytoplasmic antibodies in Bulgaria – epidemiological, health-demographic and clinical-pharmacological real-world data [PDF]

Pharmacia
Systemic vasculitides are rare and heterogeneous diseases affecting different organs and systems with varying degrees of severity depending on the type of vessels affected. The etiology and pathogenesis are unclear.
Iva Parvova, Tzvetomir Delyiski, Parvoleta Peteva, Lubomir Marinchev, Emil Hristov, Emanuil Yordanov, Valentina Petkova   +6 more
doaj   +3 more sources

Eosinophils in anti-neutrophil cytoplasmic antibody associated vasculitis

BMC Rheumatology, 2019
Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) are characterized by autoimmune small vessel inflammation. Eosinophils are multifunctional cells with both pro-inflammatory and immunoregulatory properties. Tissue activated eosinophils secrete cyto- and chemokines and form extracellular traps (EETs), they release free granules and ...
Thomas Hellmark, Sophie Ohlsson, Åsa Pettersson, Markus Hansson, Åsa C. M. Johansson   +4 more
openaire   +3 more sources

WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M6A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis

Advanced Science, EarlyView.
Scheme of the KLF9/WTAP/YTHDF2/m6A/CSF1R regulatory axis in osteoclastogenesis and estrogen‐deficient osteoporosis. WTAP‐mediated m6A modification of Csf1r mRNA governs osteoclastogenesis via a YTHDF2‐mediated pathway. Pathological upregulation of KLF9 drives Wtap transcription, leading to increased m6A deposition on the 3’‐UTR of Csf1r mRNA.
Chen Shen, Xin Liu, Gaoran Ge, Li Xu, Ziyu Zhang, Chang Lv, Hao Xu, Wenhao Li, Yi Qin, Qifeng Sheng, Qihan Wang, Hongxia Li, Jun Zhou, Huilin Yang, Dechun Geng   +14 more
wiley   +1 more source

Detection of Anti-Lactoferrin and Anti-Lysozyme in Ulcerative Colitis Patients

Diyala Journal of Medicine, 2019
Background: Ulcerative colitis is an autoimmune inflammatory disease. Perinuclear anti-neutrophil cytoplasmic antibodies have been described in patients with inflammatory bowel disease, mainly ulcerative colitis, their role in pathogenesis and ...
Abbas Jassim Mohammed
doaj   +2 more sources

Recent advances in anti-neutrophil cytoplasmic antibody-associated vasculitis

, 2016
Anti-neutrophil cytoplasmic antibody-associated vasculitis is an uncommon inflammatory disease of small to medium-sized vessels that frequently presents with rapidly progressive glomerulonephritis and renal failure though it can affect any organ system ...
O'Callaghan, C., Ranganathan, D, John, G. T., John, GT, OCallaghan, C, Lazarus, B., Ranganathan, D., Lazarus, B   +7 more
core   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source