Results 41 to 50 of about 37,560 (244)

Anti-Ly6G binding and trafficking mediate positive neutrophil selection to unleash the anti-tumor efficacy of radiation therapy

OncoImmunology, 2021
The anti-Ly6G antibody is used to deplete Ly6Gpos neutrophils and study their role in diverse pathologies. However, depletion is never absolute, as Ly6Glow neutrophils resistant to depletion rapidly emerge.
Gaël Boivin, Pierre-Benoit Ancey, Romain Vuillefroy de Silly, Pradeep Kalambaden, Caroline Contat, Benoit Petit, Jonathan Ollivier, Jean Bourhis, Etienne Meylan, Marie-Catherine Vozenin   +9 more
doaj   +1 more source

Mesenchymal Stem Cell‐Inspired Microneedle Platform for NIR‐responsive Immunomodulation and Accelerated Chronic Wound Healing

Advanced Materials, EarlyView.
The research demonstrates a Mesenchymal Stem Cell‐inspired microneedle platform (MSCi@MN) that addresses chronic diabetic wounds by combining MSC‐derived extracellular nanovesicles (NV)–DNA conjugates in microneedle tips with photothermal MXene in the patch layer.
Chan Ho Moon, Hee Gyeong Ko, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Jong Hwa Seo, Nayoung Lee, So Won Jeon, Yun‐A Kim, Jong Sang Yoon, Kyung‐Yup Cha, Min‐Ho Kang, Dong Yun Lee, Soo‐Hong Lee, Gi Doo Cha, Kisuk Yang, Donghyun Lim, Heemin Kang, Su Ryon Shin, Han Young Kim, Hyun‐Do Jung   +21 more
wiley   +1 more source

A decade long experience of anti-neutrophil cytoplasmic antibody testing in a tertiary care referral center in North India: Perspective from a developing country

Indian Journal of Pathology and Microbiology, 2011
Background: In a developing, tropical country like India, discontinuous power supply, high temperatures during summer, and lack of consistent cold chain and funds provide a challenging atmosphere for anti-neutrophil cytoplasmic antibody (ANCA) testing ...
Ranjana W Minz, Seema Chhabra, Lekha Rani, Surjit Singh, Surinder K Jindal, Vinay Sakhuja   +5 more
doaj   +1 more source

Dialysis Dependency at Discharge in De Novo ANCA Associated Renal Limited Vasculitis: Should We Avoid Further Immunosuppression?

Revista Portuguesa de Nefrologia e Hipertensão, 2022
Introduction: ANCA associated vasculitis commonly affects the kidneys. The intense inflammatory damage disrupts the glomerular architecture. Induction immunosuppressive therapy is responsible for a large part of the morbidity and mortality of these ...
Rui Filipe Nogueira, Nuno Afonso Oliveira, Margarida Gaudêncio, Ana Belmira, Rui Alves   +4 more
doaj   +1 more source

Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
Single‐cell transcriptomic and functional analyses identify SEMA3C as a key regulator of tumor progression and tumor microenvironment remodeling in penile squamous cell carcinoma. SEMA3C promotes epithelial–mesenchymal transition, tumor growth, and invasion while shaping an immunosuppressive microenvironment, highlighting its potential as a prognostic ...
Xiheng Hu, Wensheng Shi, Liang Dong, Lingjuan Huang, Xiyuan Zhang, Yiting Feng, Jie Sun, Lanlan Liu, Teng Liu, Jun Fu, Bowen Zhong, Qihao Leng, Xiaohua Wu, Minfeng Chen, Lingfang Li, Yuan Li, Xin Jin, Long Wang, Jian Cao, Xin Li, Mingzhu Yin, Xiang Chen   +21 more
wiley   +1 more source

Expression of serum soluble Klotho protein in patients with renal damage induced by anti-neutrophil cytoplasmic antibody-associated small-vessel vasculitis and influence on prognosis

Romanian Journal of Laboratory Medicine, 2022
Background: Anti-neutrophil cytoplasmic antibody-associated small-vessel vasculitis (AASV) is an autoimmune disease with unclear pathogenesis, which causes damage to multiple organs and systems, renal failure or even death.
Ma Feiju, Li Jianfei
doaj   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Update of Management of ANCA-Associated Vasculitis

Journal of Clinical Rheumatology and Immunology, 2021
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is associated with significant morbidity and mortality. Management of AAV is divided into induction of remission and maintenance of remission.
Hoi San Tang, Shirley King Yee
doaj   +1 more source

Cardiovascular Disease in Anti-neutrophil Cytoplasm Antibody-Associated Vasculitis

Current Rheumatology Reports, 2023
Abstract Purpose of Review Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a rare, multisystem, autoimmune disease characterised by microvascular inflammation. Over the past 20 years, advances in immunological management have improved short-term patient outcomes.
Matthew Sayer, Gavin B. Chapman, Matthew Thomas, Neeraj Dhaun   +3 more
openaire   +3 more sources

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source