Automated Processing and Evaluation of Anti-Nuclear Antibody Indirect Immunofluorescence Testing [PDF]
Frontiers in Immunology, 2018 Indirect immunofluorescence (IIF) is considered by the American College of Rheumatology (ACR) and the international consensus on ANA patterns (ICAP) the gold standard for the screening of anti-nuclear antibodies (ANA).
Vincent Ricchiuti +4 more
doaj +6 more sources
Presence of anti-nuclear antibody associated with worse clinical outcomes of anti-NMDAR encephalitis [PDF]
Frontiers in Neurology, 2022 PurposeSystemic autoantibodies are important for the diagnosis of autoimmune diseases, but their roles in anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis are unknown.
Chunyan Lei +5 more
doaj +2 more sources
Clinics, 2011 INTRODUCTION: Epstein-Barr virus exposure appears to be an environmental trigger for rheumatoid arthritis that interacts with other risk factors. Relationships among anti-cyclic citrullinated peptide antibodies, the shared epitope, and smoking status ...
Michel Alexandre Yazbek +5 more
doaj +2 more sources
The origin of anti-nuclear antibodies in bcl-2 transgenic mice [PDF]
International Immunology, 2000 bcl-2 transgenic mice develop anti-double-stranded (ds) DNA antibodies similar to those present in systemic lupus erythematosus. To begin to understand where a breakdown in the regulation of autoreactive lymphocytes is occurring, we have used a bcl-2 transgene (Tg) in conjunction with an Ig Tg that allows us to identify and track anti-dsDNA B cells ...
Laura Mandik‐Nayak +6 more
openalex +4 more sources
Anti-nuclear antibody screening using HEp-2 cells. [PDF]
J Vis Exp, 2014 The American College of Rheumatology position statement on ANA testing stipulates the use of IIF as the gold standard method for ANA screening(1). Although IIF is an excellent screening test in expert hands, the technical difficulties of processing and reading IIF slides--such as the labor intensive slide processing, manual reading, the need for ...
Buchner C, Bryant C, Eslami A, Lakos G.
europepmc +5 more sources
Anti-Nuclear Antibody (ANA) Positivity and Nuclear Antigen Reactivity in Patients with Joint Hypermobility Syndrome/Hypermobile Ehlers Danlos Syndrome (JHS/hEDS) [PDF]
BiomedicinesBackground/Objectives: To compare clinical features of patients with joint hypermobility syndrome/hypermobile Ehlers Danlos Syndrome (JHS/hEDS) who tested positive or negative for anti-nuclear antibodies (ANA), and to determine antibody titers, staining ...
Lindsay Moy +2 more
doaj +2 more sources
Anti-nuclear antibodies: A practical approach to testing and interpretation
Journal of Skin and Sexually Transmitted Diseases, 2020 Anti-nuclear antibodies (ANAs) are a group of antibodies that are characteristically associated with connective tissue diseases (CTDs). Indirect immunofluorescence antibody technique, having a high sensitivity, is the most common technique used for detection, results of which are expressed in terms of the pattern of fluorescence, substrate used, and ...
Parvathy Santhosh +1 more
openalex +3 more sources
Determination of Anti-nuclear Antibody Pattern Distribution and Clinical Relationship. [PDF]
Pak J Med Sci, 2014 Autoantibodies are immunglobulins occurred directly against autoantigens that are known as endogen antigens. Autoimmune disease is an occasion that the body begins a fight against its own cells and tissues. The antibodies that are created by the body against its own cell nuclei are called as anti-nuclear antibodies (ANA), and one of the methods used ...
Mengeloglu Z +4 more
europepmc +4 more sources
Diagnostic significance of combined anti-extractable nuclear antigens antibody, anti-cardiolipin antibody and anti-β2-glycoprotein 1 in systemic lupus erythematosus patients [PDF]
HeliyonObjective: This study aimed to investigate the diagnostic value of a combination of anti-extractable nuclear antigens (anti-ENA) antibodies, anti-cardiolipin antibodies (ACA), and anti-β2-glycoprotein 1 (anti-β2 GPI) antibodies in patients with systemic ...
Xuan Sun +5 more
doaj +2 more sources
Relationship between autoimmune thyroid antibodies and anti-nuclear antibodies in general patients [PDF]
Frontiers in EndocrinologyBackgroundThere is no doubt that both Hashimoto thyroiditis and Graves’ disease are autoimmune thyroid diseases (AITDs), but the relationship between anti-nuclear antibody (ANA) and AITDs is poorly studied. The association between thyroid autoantibody levels and ANA positivity was evaluated to assess the role of ANA in AITDs.MethodsWe conducted an ...
Yi Ruan +8 more
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