Automated Processing and Evaluation of Anti-Nuclear Antibody Indirect Immunofluorescence Testing. [PDF]
Front Immunol, 2018 Indirect immunofluorescence (IIF) is considered by the American College of Rheumatology (ACR) and the international consensus on ANA patterns (ICAP) the gold standard for the screening of anti-nuclear antibodies (ANA).
Ricchiuti V +4 more
europepmc +7 more sources
Anti-nuclear antibody screening using HEp-2 cells. [PDF]
J Vis Exp, 2014 The American College of Rheumatology position statement on ANA testing stipulates the use of IIF as the gold standard method for ANA screening(1). Although IIF is an excellent screening test in expert hands, the technical difficulties of processing and reading IIF slides--such as the labor intensive slide processing, manual reading, the need for ...
Buchner C, Bryant C, Eslami A, Lakos G.
europepmc +6 more sources
Determination of Anti-nuclear Antibody Pattern Distribution and Clinical Relationship. [PDF]
Pak J Med Sci, 2014 Background and Objectives: Autoantibodies are immunglobulins occurred directly against autoantigens that are known as endogen antigens. Autoimmune disease is an occasion that the body begins a fight against its own cells and tissues.
Mengeloglu Z +4 more
europepmc +5 more sources
Salivary anti-nuclear antibody (ANA) mirrors serum ANA in systemic lupus erythematosus. [PDF]
Arthritis Res Ther, 2022 Objectives To assay salivary anti-nuclear antibody (ANA) and its isotypes in patients with systemic lupus erythematosus (SLE) and to investigate relevant clinical associations.
Zhang T +9 more
europepmc +2 more sources
Current laboratory and clinical practices in reporting and interpreting anti-nuclear antibody indirect immunofluorescence (ANA IIF) patterns: results of an international survey. [PDF]
Auto Immun Highlights, 2020 Background The International Consensus on Antinuclear Antibody (ANA) Patterns (ICAP) has recently proposed nomenclature in order to harmonize ANA indirect immunofluorescence (IIF) pattern reporting.
Van Hoovels L +29 more
europepmc +2 more sources
Value of combined detection of anti-nuclear antibody, anti-double-stranded DNA antibody and C3, C4 complements in the clinical diagnosis of systemic lupus erythematosus. [PDF]
Exp Ther Med, 2019 Combined detection of antinuclear antibody (ANA), anti-double-stranded DNA (ds-DNA) antibody and complements C3 and C4 in the diagnosis of systemic lupus erythematosus (SLE) was analyzed.
Qu C +5 more
europepmc +2 more sources
Presence of an interferon signature in individuals who are anti-nuclear antibody positive lacking a systemic autoimmune rheumatic disease diagnosis. [PDF]
Arthritis Res Ther, 2017 BackgroundElevated levels of type I interferons (IFNs) are a characteristic feature of the systemic autoimmune rheumatic diseases (SARDs) and are thought to play an important pathogenic role.
Wither J +8 more
europepmc +2 more sources
An automatic segmentation and classification framework for anti-nuclear antibody images [PDF]
BioMedical Engineering OnLine, 2013 Autoimmune disease is a disorder of immune system due to the over-reaction of lymphocytes against one's own body tissues. Anti-Nuclear Antibody (ANA) is an autoantibody produced by the immune system directed against the self body tissues or cells, which ...
Chung-Chuan Cheng +3 more
semanticscholar +4 more sources
The origin of anti-nuclear antibodies in bcl-2 transgenic mice [PDF]
International Immunology, 2000 bcl-2 transgenic mice develop anti-double-stranded (ds) DNA antibodies similar to those present in systemic lupus erythematosus. To begin to understand where a breakdown in the regulation of autoreactive lymphocytes is occurring, we have used a bcl-2 transgene (Tg) in conjunction with an Ig Tg that allows us to identify and track anti-dsDNA B cells ...
Laura Mandik‐Nayak +6 more
openalex +4 more sources
Annals of Neurology, 2022 The antigen specificity of Anti‐Neuronal Nuclear Antibody‐type 3 (ANNA3)‐IgG is unknown. We identified Dachshund‐homolog 1 (DACH1) as the ANNA3 autoantigen and confirmed it by antigen‐specific assays, immunohistochemical colocalization and immune ...
Αναστασία Ζεκερίδου +8 more
openalex +3 more sources