Results 1 to 10 of about 63,635 (266)

IL-1β/IL-1Ra ratio dysregulation in islet autoantibody–positive adult-onset diabetes [PDF]

Frontiers in Immunology
BackgroundThe IL-1 pathway plays a central role in β-cell dysfunction; however, the relationship between IL-1β/IL-1Ra imbalance and islet autoimmunity in newly diagnosed adult-onset diabetes remains insufficiently defined.
Bibigul Tleumagambetova, Khatimya Kudabayeva, Yerlan Bazargaliyev, Lorina Vudu   +3 more
doaj   +2 more sources

Comprehensive autoantibody profiling in systemic autoimmunity by a highly-sensitive multiplex protein array

Frontiers in Immunology, 2023
Comprehensive autoantibody evaluation is essential for the management of autoimmune disorders. However, conventional methods suffer from poor sensitivity, low throughput, or limited availability.
Shinichi Sato, Takashi Matsushita, Takashi Yamashita   +2 more
exaly   +3 more sources

Anti-Myxovirus Resistance Protein-1 Immunoglobulin A Autoantibody in Idiopathic Pulmonary Fibrosis

Canadian Respiratory Journal, 2022
Background. We have previously analysed serum autoantibody levels in patients with idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (iNSIP), and healthy controls and identified the autoantibody against anti-myxovirus ...
Toru Arai, Masaki Hirose, Yoshimasa Hamano, Tomoko Kagawa, Akihiro Murakami, Hiroshi Kida, Atsushi Kumanogoh, Yoshikazu Inoue   +7 more
doaj   +1 more source

The effect of thyroid autoantibody on assisted reproduction technology outcome in euthyroid women: One center experience

Pakistan Journal of Pharmaceutical Sciences, 2021
Thyroid dysfunction is an important factor to cause failure in assisted reproduction technology (ART) procedures. In this study, we recorded the serum level of thyroid autoantibody to fig. out its relationship with the ART outcome.
Lili Zhuang, Xiaoyan Liu, Jianxiang Cong, Ning Zhang, Qinglan Qu, Cuifang Hao   +5 more
doaj   +1 more source

Effectiveness of pirfenidone in idiopathic pulmonary fibrosis according to the autoantibody status: a retrospective cohort study

BMC Pulmonary Medicine, 2021
Background Pirfenidone is an anti-fibrotic agent shown to slow the progression of idiopathic pulmonary fibrosis (IPF). However, its effectiveness in association with serological autoimmune features in IPF remains unclear.
Myung Jin Song, Sang Hoon Lee, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Joon Chang, Song Yee Kim   +7 more
doaj   +1 more source

First-emerging islet autoantibody and glucose metabolism: search for type 1 diabetes subtypes

Endocrine Connections, 2022
Objective: Subtypes in type 1 diabetes pathogenesis have been implicated based on the first-appearing autoantibody (primary autoantibody). We set out to describe the glucose metabolism in preclinical diabetes in relation to the primary autoantibody in ...
Olli Helminen, Tytti Pokka, Susanna Aspholm, Jorma Ilonen, Olli G Simell, Mikael Knip, Riitta Veijola   +6 more
doaj   +1 more source

Correlates of survival after autoantibody reduction therapy for acute IPF exacerbations.

PLoS ONE, 2021
BackgroundNo medical treatment has proven efficacy for acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF), and this syndrome has a very high mortality.
Tejaswini Kulkarni, Vincent G Valentine, Fei Fei, Thi K Tran-Nguyen, Luisa D Quesada-Arias, Takudzwa Mkorombindo, Huy P Pham, Sierra C Simmons, Kevin G Dsouza, Tracy Luckhardt, Steven R Duncan   +10 more
doaj   +1 more source

Use of two methods to elute anti-IgG and anti-(IgG + C3d) type autoantibody from sensitized erythrocytes

Global Journal of Transfusion Medicine, 2018
Background: Autoimmune hemolytic anemia (AIHA) is an immunological disease caused by autoantibodies. Warm autoantibody mainly includes anti-IgG and anti-(IgG+C3d) type, which can cause direct antiglobulin test (DAT) positive.
He Ziyi, Hu Yingming, Cui Siping
doaj   +1 more source

Autoantibody of NRIP, a novel AChR‐interacting protein, plays a detrimental role in myasthenia gravis

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Nuclear receptor interaction protein (NRIP) co‐localizes with acetylcholine receptor (AChR) at the neuromuscular junction (NMJ), and NRIP deficiency causes aberrant NMJ architecture.
Li‐Kai Tsai, I‐Hsin Chen, Chi‐Chao Chao, Hsueh‐Wen Hsueh, Hsin‐Hsiung Chen, Yun‐Hsin Huang, Rong‐Wei Weng, Tzu‐Yun Lai, Yi‐Chieh Tsai, Yeou‐Ping Tsao, Show‐Li Chen   +10 more
doaj   +1 more source

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice

Cell Reports, 2015
Immunoglobulin G (IgG) antibodies are major drivers of autoimmune pathology, but they are also used in the form of intravenous IgG (IVIg) therapy to suppress autoantibody activity. To identify the pathways underlying human autoantibody and IVIg activity,
Inessa Schwab, Anja Lux, Falk Nimmerjahn
doaj   +1 more source