Results 11 to 20 of about 195,106 (347)
Comprehensive overview of autoantibody isotype and subclass distribution. [PDF]
Journal of Allergy and Clinical Immunology, 2022 The presence of autoreactive antibodies is a hallmark of many autoimmune diseases. The effector functions of (auto)antibodies are determined by their constant domain, which defines the antibody isotype and subclass. The most prevalent isotype in serum is
M. Volkov +15 more
semanticscholar +6 more sources
PLoS Medicine, 2020 BackgroundBased on different genetic and environmental risk factors and histology, it has been proposed that rheumatoid arthritis (RA) consists of 2 types: autoantibody-positive and autoantibody-negative RA. However, until now, this remained hypothetical.
Xanthe M E Matthijssen +3 more
doaj +2 more sources
Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody
Cell, 2020 Pathogenic autoantibodies arise in many autoimmune diseases, but it is not understood how the cells making them evade immune checkpoints. Here, single-cell multi-omics analysis demonstrates a shared mechanism with lymphoid malignancy in the formation of ...
Christopher Goodnow +2 more
exaly +2 more sources
Autoantibody-Specific Signalling in Pemphigus [PDF]
Frontiers in Medicine, 2021 Pemphigus is a severe autoimmune disease impairing barrier functions of epidermis and mucosa. Autoantibodies primarily target the desmosomal adhesion molecules desmoglein (Dsg) 1 and Dsg 3 and induce loss of desmosomal adhesion.
T. Schmitt, J. Waschke
semanticscholar +2 more sources
Türk Oftalmoloji Dergisi, 2017 Objectives: To investigate the relationship between serum carbonic anhydrase I-II (CA-I and II) autoantibody levels and diabetic retinopathy (DRP) in cases with type 1 diabetes. Materials and Methods: A total of 37 type-1 diabetic patients, 17 with DRP (
Adem Türk +6 more
doaj +2 more sources
Mechanisms of Autoantibody-Induced Pathology [PDF]
Frontiers in Immunology, 2017 Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves’ disease.
R. Ludwig +23 more
semanticscholar +2 more sources
Immune network dysregulation in rheumatoid arthritis and systemic lupus erythematosus: cytokine signatures, autoantibody profiles, and implications for precision medicine [PDF]
Frontiers in MedicineBackgroundRheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are systemic autoimmune diseases characterized by chronic inflammation, immune dysregulation, and heterogeneous clinical manifestations. Despite differences in target organs, both
Benjuan Wu, Liya Zhang, Fuxi Chen
doaj +2 more sources
Anti-Myxovirus Resistance Protein-1 Immunoglobulin A Autoantibody in Idiopathic Pulmonary Fibrosis
Canadian Respiratory Journal, 2022 Background. We have previously analysed serum autoantibody levels in patients with idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (iNSIP), and healthy controls and identified the autoantibody against anti-myxovirus ...
Toru Arai +7 more
doaj +2 more sources
Individual and stable autoantibody repertoires in healthy individuals
Autoimmunity, 2019 In the era towards precision medicine, we here present the individual specific autoantibody signatures of 193 healthy individuals. The self-reactive IgG signatures are stable over time in a way that each individual profile is recognized in longitudinal ...
David Just +2 more
exaly +2 more sources
Systemic translocation of Staphylococcus drives autoantibody production in HIV disease
Microbiome, 2019 Background Increased autoreactive antibodies have been reported in HIV disease; however, the mechanism accounting for autoantibody induction in HIV remains unknown.
Zhenwu Luo +21 more
doaj +2 more sources