Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits [PDF]
, 2008 Background: In celiac disease gluten, the disease-inducing toxic component in wheat, induces the secretion of autoantibodies which are targeted against transglutaminase 2 (TG2). These autoantibodies are produced in the small-intestinal mucosa, where they
Markku Maki +31 more
core +1 more source
Clinical and autoantibody phenotypes of juvenile dermatomyositis
, 2022 Juvenile dermatomyositis (JDM) is a heterogeneous autoimmune inflammatory myositis with symmetrical proximal muscle weakness and a characteristic rash. Juvenile dermatomyositis is characterized by variable presentation and phenotypes.
Iryna Yuryk +5 more
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Myasthenia Gravis: Autoantibody Specificities and Their Role in MG Management
Frontiers in Neurology, 2020 Myasthenia gravis (MG) is the most common autoimmune disorder affecting the neuromuscular junction, characterized by skeletal muscle weakness and fatigability.
K. Lazaridis, S. Tzartos
semanticscholar +1 more source
Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis. [PDF]
, 2010 The objective of the study was to determine the presence or levels of antibodies (Abs) against caspase-3 and their clinical relevance in systemic sclerosis (SSc). Anti-caspase-3 Ab was examined by enzyme-linked immunosorbent assay and immunoblotting. IgG
Ogawa, Fumihide +10 more
core +1 more source
Journal of Cachexia, Sarcopenia and Muscle, 2021 Background Nuclear receptor interaction protein (NRIP) co‐localizes with acetylcholine receptor (AChR) at the neuromuscular junction (NMJ), and NRIP deficiency causes aberrant NMJ architecture.
Li‐Kai Tsai +10 more
doaj +1 more source
Cell Reports, 2015 Immunoglobulin G (IgG) antibodies are major drivers of autoimmune pathology, but they are also used in the form of intravenous IgG (IVIg) therapy to suppress autoantibody activity. To identify the pathways underlying human autoantibody and IVIg activity,
Inessa Schwab, Anja Lux, Falk Nimmerjahn
doaj +1 more source
Comparison of clinical and laboratory characteristics in children with type 1 diabetes according to pancreatic autoantibodies [PDF]
Korean Journal of Pediatrics, 2010 Purpose:The purpose of this study was to determine whether there is any difference in the clinical and laboratory characteristics of patients with autoantibody-positive and patients with autoantibody-negative type 1 diabetes at initial presentation ...
Ji Hae Choi +4 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundChronic immune stimulation by hepatitis C virus (HCV) may cause occurrence of several autoantibodies in infected patients, with or without features of clinically overt autoimmune diseases.
Ciro Romano +6 more
doaj +1 more source
Different Hierarchies of Anti–Modified Protein Autoantibody Reactivities in Rheumatoid Arthritis
Arthritis & Rheumatology, 2020 Anti–citrullinated protein antibodies (ACPAs) are a hallmark of seropositive rheumatoid arthritis (RA). Yet, the precise disease‐relevant autoantigens that are targeted by ACPAs remains a matter of debate.
P. Sahlström +15 more
semanticscholar +1 more source
Prevalence and reactivity of anti-melanoma differentiation-associated gene 5 (anti-MDA-5) autoantibody in Brazilian patients with dermatomyositis [PDF]
Anais Brasileiros de Dermatologia, 2018 : Background: There have been no studies to date on the frequency and reactivity of aanti-melanoma differentiation-associated gene 5 (anti-MDA-5) in samples from the Brazilian population with dermatomyositis. Objectives: To analyze this autoantibody in
Isabela Bruna Pires Borges +2 more
doaj +1 more source