Results 61 to 70 of about 195,106 (347)

Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody–Positive Individuals

Diabetes Care, 2020
OBJECTIVE Most individuals with two or more islet autoantibodies progress to clinical type 1 diabetes. However, in some individuals, autoantibodies are subsequently lost.
Michelle So, Colin O’Rourke, H. Bahnson, C. Greenbaum, C. Speake   +4 more
semanticscholar   +1 more source

Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups

Annals of the Rheumatic Diseases, 2019
Objectives Idiopathic inflammatory myopathies (IIM) are a spectrum of rare autoimmune diseases characterised clinically by muscle weakness and heterogeneous systemic organ involvement.
S. Rothwell, H. Chinoy, J. Lamb, F. Miller, L. Rider, L. Wedderburn, N. McHugh, A. Mammen, Z. Betteridge, S. Tansley, J. Bowes, J. Vencovský, C. Deakin, K. Dankó, L. Vidya, A. Selva-O’Callaghan, L. Pachman, A. Reed, Ø. Molberg, O. Benveniste, P. Mathiesen, T. Radstake, A. Doria, J. D. De Bleecker, A. Lee, M. Hanna, P. Machado, W. Ollier, P. Gregersen, L. Padyukov, T. O’Hanlon, R. Cooper, I. Lundberg   +32 more
semanticscholar   +1 more source

Advancing Luciferase-Based Antibody Immunoassays to Next-Generation Mix and Read Testing

Biosensors, 2023
Antibody measurements play a central role in the diagnosis of many autoimmune and infectious diseases. One antibody detection technology, Luciferase Immunoprecipitation Systems (LIPS), utilizes genetically encoded recombinant luciferase antigen fusion ...
Peter D. Burbelo, Youngmi Ji, Michael J. Iadarola   +2 more
doaj   +1 more source

Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production.

Brain : a journal of neurology, 2019
Neuromyelitis optica spectrum disorders (NMOSD) constitute rare autoimmune disorders of the CNS that are primarily characterized by severe inflammation of the spinal cord and optic nerve. Approximately 75% of NMOSD patients harbour circulating pathogenic
E. Cotzomi, P. Stathopoulos, Casey S. Lee, A. Ritchie, J. Soltys, F. Delmotte, T. Oe, Joel Sng, Ruoyi Jiang, Anthony K Ma, Jason A. Vander Heiden, S. Kleinstein, M. Levy, J. Bennett, E. Meffre, K. O'Connor   +15 more
semanticscholar   +1 more source

Autoantibody prevalence in children with liver disease due to chronic hepatitis C virus (HCV) infection.

, 1998
HCV infection and interferon-alpha (IFN-alpha) therapy have been associated with autoimmunity. To assess whether chronic liver disease (CLD) due to HCV infection or its treatment with IFN-alpha cause autoimmune manifestations, the prevalence of tissue ...
GREGORIO GV, IORIO, RAFFAELE, VERGANI D. AUTOANTIBODY PREVALENCE IN CHILDREN WITH LIVER DISEASE DUE TO CHRONIC HEPATITIS C. VIRUS HCV I.N.F.E.C.T.I.O.N. CLIN EXP IMMUNOL, VEGNENTE A, PENSATI P, MIELI VERGANI G   +5 more
core   +1 more source

GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis

Nature Communications, 2018
Autoantibodies have been associated with autoimmune diseases. However, studies have identified autoantibodies in healthy donors (HD) who do not develop autoimmune disorders.
O. Cabral-Marques, A. Marques, L. Giil, R. De Vito, J. Rademacher, J. Günther, T. Lange, J. Humrich, S. Klapa, S. Schinke, Lena F. Schimke, Gabriele Marschner, S. Pitann, S. Adler, R. Dechend, Dominik N. Müller, I. Braicu, J. Sehouli, K. Schulze-Forster, T. Trippel, C. Scheibenbogen, A. Staff, P. Mertens, Madlen Löbel, Justin Mastroianni, Corinna Plattfaut, F. Gieseler, D. Dragun, B. Engelhardt, M. Fernandez-Cabezudo, H. Ochs, B. al-Ramadi, P. Lamprecht, A. Mueller, H. Heidecke, G. Riemekasten   +35 more
semanticscholar   +1 more source

Anti-BIRC5 autoantibody serves as a valuable biomarker for diagnosing AFP-negative hepatocellular carcinoma [PDF]

PeerJ
Background Autoantibodies targeting tumor-associated antigens (TAAbs) have emerged as promising biomarkers for early cancer detection. This research aimed to assess the diagnostic capacity of anti-BIRC5 autoantibody in detecting AFP-negative ...
Qing Li, Haiyan Liu, Han Wang, Wenzhuo Xiong, Liping Dai, Xiuzhi Zhang, Peng Wang, Hua Ye, Jianxiang Shi, Zhihao Fang, Keyan Wang   +10 more
doaj   +2 more sources

Autoantibody Development under Treatment with Immune-Checkpoint Inhibitors

Cancer immunology research, 2018
Ipilimumab induced autoantibodies in a fifth of melanoma patients. Patients who developed autoantibodies, especially thyroid autoantibodies, experienced more irAEs and had a survival and response benefit, suggesting that breaking of B-cell tolerance ...
Emma C. de Moel, E. Rozeman, E. Kapiteijn, E. Verdegaal, A. Grummels, J. Bakker, T. Huizinga, J. Haanen, R. Toes, D. van der Woude   +9 more
semanticscholar   +1 more source

Determination of anti-ADAMTS-13 autoantibody titers in ELISA: Influence of ADAMTS-13 presentation and autoantibody detection

, 2021
BACKGROUND: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is caused by inhibitory and/or clearing anti-ADAMTS-13 (A Disintegrin and Metalloprotease with ThromboSpondin type 1 repeats, member 13) autoantibodies.
Mannik, Andres, Tellier, Edwige, Feys, Hendrik B., Kaplanski, Gilles, Vandenbulcke, Aline, Dekimpe, Charlotte, De Meyer, Simon F., Feys, Hendrik, Bonnez, Quintijn, Tersteeg, Claudia, Roose, Elien, Vanhoorelbeke, Karen, Kangro, Kadri, de Meyer, Simon   +13 more
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source