Results 81 to 90 of about 195,106 (347)

Assessing the Sensitivity and the Clinical Impact of the 2023 American College of Rheumatology/EULAR Classification Criteria in Obstetric Antiphospholid Syndrome: Findings From a Multicenter Italian Cohort With a Long‐Term Follow‐Up

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to evaluate the sensitivity of the 2023 American College of Rheumatology (ACR)/EULAR classification criteria for antiphospholipid syndrome (APS) in a real‐world cohort of women diagnosed with primary obstetric APS (oAPS) and to assess their ability to identify patients at risk of future pregnancy complications ...
Francesca Ruffilli, Cecilia Nalli, Francesca Crisafulli, Carlo Garaffoni, Marcello Govoni, Giulia Voltarel, Alba C. Pozzi, Beatrice Maranini, Ettore Silvagni, Alessandra Bortoluzzi, Angela Tincani   +10 more
wiley   +1 more source

Low T-cell reactivity to TDP-43 peptides in ALS

Frontiers in Immunology, 2023
BackgroundDysregulation of the immune system in amyotrophic lateral sclerosis (ALS) includes changes in T-cells composition and infiltration of T cells in the brain and spinal cord.
Swetha Ramachandran, Veselin Grozdanov, Bianca Leins, Katharina Kandler, Simon Witzel, Medhanie Mulaw, Albert C. Ludolph, Albert C. Ludolph, Jochen H. Weishaupt, Karin M. Danzer, Karin M. Danzer   +10 more
doaj   +1 more source

Anti-citrullinated Protein Antibody Generation, Pathogenesis, Clinical Application, and Prospects

Frontiers in Medicine, 2022
Anti-citrullinated protein antibodies (ACPAs) are autoantibodies commonly observed in patients with rheumatoid arthritis (RA). Currently, most of the mechanisms of ACPA formation and bone destruction are well-understood, however, some unknown mechanisms ...
Jiaxi Liu, Jinfang Gao, Zewen Wu, Liangyu Mi, Na Li, Yajing Wang, Xinyue Peng, Ke Xu, Fengping Wu, Liyun Zhang   +9 more
doaj   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

IL-1β/IL-1Ra ratio dysregulation in islet autoantibody–positive adult-onset diabetes

Frontiers in Immunology
BackgroundThe IL-1 pathway plays a central role in β-cell dysfunction; however, the relationship between IL-1β/IL-1Ra imbalance and islet autoimmunity in newly diagnosed adult-onset diabetes remains insufficiently defined.
Bibigul Tleumagambetova, Khatimya Kudabayeva, Yerlan Bazargaliyev, Lorina Vudu   +3 more
doaj   +1 more source

Anti-neurofascin autoantibody and demyelination.

Neurochemistry International, 2019
Demyelination diseases involving the central and peripheral nervous systems are etiologically heterogeneous with both cell-mediated and humoral immunities playing pathogenic roles.
J. Kira, R. Yamasaki, H. Ogata
semanticscholar   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

The interference of anti-TSH autoantibody on clinical TSH detection

Frontiers in Endocrinology
ObjectiveIt is well known that macro-thyroid-stimulating hormone (macro-TSH) could interfere with the detection of TSH. The anti-TSH autoantibody is an essential component of macro-TSH.
Mulin Tang, Xue Meng, Jiajia Ni, Xue Liu, Xinhui Wang, Yuchen Li, Yuwei Chai, Chunjia Kou, Li Zhang, Haiqing Zhang, Haiqing Zhang, Haiqing Zhang, Haiqing Zhang   +12 more
doaj   +1 more source

Autoantibodies Against the Complement Regulator Factor H in the Serum of Patients With Neuromyelitis Optica Spectrum Disorder

Frontiers in Immunology, 2021
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system (CNS), characterized by pathogenic, complement-activating autoantibodies against the main water channel in the CNS, aquaporin 4 (AQP4 ...
Barbara Uzonyi, Barbara Uzonyi, Zsóka Szabó, Eszter Trojnár, Eszter Trojnár, Satu Hyvärinen, Katalin Uray, Helle H. Nielsen, Anna Erdei, Anna Erdei, T. Sakari Jokiranta, Zoltán Prohászka, Zoltán Prohászka, Zsolt Illes, Zsolt Illes, Mihály Józsi, Mihály Józsi, Mihály Józsi   +17 more
doaj   +1 more source

Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease

Nature Immunology, 2016
The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the TH17 subset of helper T cells as a decisive factor that controlled the ...
R. Pfeifle, T. Rothe, N. Ipseiz, H. Scherer, S. Culemann, U. Harre, Jochen A. Ackermann, M. Seefried, A. Kleyer, S. Uderhardt, Benjamin Haugg, A. Hueber, Patrick Daum, Gordon F Heidkamp, C. Ge, Sybille Böhm, A. Lux, W. Schuh, I. Magorivska, Kutty Selva Nandakumar, E. Lönnblom, C. Becker, D. Dudziak, M. Wuhrer, Y. Rombouts, C. Koeleman, R. Toes, T. Winkler, R. Holmdahl, M. Herrmann, S. Blüml, F. Nimmerjahn, G. Schett, G. Krönke   +33 more
semanticscholar   +1 more source