Results 21 to 30 of about 195,106 (347)

Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study [PDF]

Diabetes Care, 2020
OBJECTIVE The first-appearing β-cell autoantibody has been shown to influence risk of type 1 diabetes (T1D). Here, we assessed the risk of autoantibody spreading to the second-appearing autoantibody and further progression to clinical disease in The ...
K. Vehik, E. Bonifacio, Å. Lernmark, Liping Yu, A. Williams, D. Schatz, M. Rewers, J. She, J. Toppari, W. Hagopian, B. Akolkar, A. Ziegler, J. Krischer, T. A. S. Group   +13 more
semanticscholar   +2 more sources

Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dogs

Journal of Veterinary Internal Medicine
Background Although the importance of early diagnosis of malignant tumors is a major concern, an easily accessible in‐house method has not been established.
Yoonhee Kim, Wonhee Lee, Byunggak Kim, Bonghwan Jang, Kyung‐Rok Yu, Hong Sook Kim, Minok Ryu, Yein Oh, Kyoungwon Seo, Chul Park, Ulsoo Choi, Dongha Bhang, Hwayoung Youn   +12 more
doaj   +2 more sources

Autoantigen Microarray for High-throughput Autoantibody Profiling in Systemic Lupus Erythematosus

Genomics, Proteomics & Bioinformatics, 2015
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the production of autoantibodies to a broad range of self-antigens. Profiling the autoantibody repertoire using array-based technology has emerged as a powerful tool for ...
Honglin Zhu, Hui Luo, Mei Yan, Xiaoxia Zuo, Quan-Zhen Li   +4 more
doaj   +2 more sources

Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

Nature Biotechnology, 2023
Muscle-specific tyrosine kinase myasthenia gravis (MuSK MG) is an autoimmune disease that causes life-threatening muscle weakness due to anti-MuSK autoantibodies that disrupt neuromuscular junction signaling.
Sangwook Oh, Xu-Ming Mao, S. Manfredo-Vieira, Jin-Min Lee, Darshil Patel, E. Choi, Andrea Alvarado, Ebony Cottman-Thomas, Damian Maseda, P. Tsao, C. Ellebrecht, S. Khella, D. Richman, K. O'Connor, U. Herzberg, Gwendolyn K. Binder, M. Milone, Samik Basu, A. Payne   +18 more
semanticscholar   +1 more source

Positive Predictive Value of Myelin Oligodendrocyte Glycoprotein Autoantibody Testing

JAMA Neurology, 2021
Key Points Question What is the positive predictive value of myelin oligodendrocyte glycoprotein (MOG)–IgG1 testing in a clinical setting? Findings Of 1260 consecutive patients tested for MOG-IgG1 at the Mayo Clinic over 2 years, 92 (7.3%) were positive,
Elia Sechi, Marina Buciuc, S. Pittock, John J. Chen, J. Fryer, Sarah M. Jenkins, A. Budhram, B. Weinshenker, A. Lopez-Chiriboga, J. Tillema, A. McKeon, J. Mills, W. Tobin, E. Flanagan   +13 more
semanticscholar   +1 more source

The effect of thyroid autoantibody on assisted reproduction technology outcome in euthyroid women: One center experience

Pakistan Journal of Pharmaceutical Sciences, 2021
Thyroid dysfunction is an important factor to cause failure in assisted reproduction technology (ART) procedures. In this study, we recorded the serum level of thyroid autoantibody to fig. out its relationship with the ART outcome.
Lili Zhuang, Xiaoyan Liu, Jianxiang Cong, Ning Zhang, Qinglan Qu, Cuifang Hao   +5 more
doaj   +1 more source

Effectiveness of pirfenidone in idiopathic pulmonary fibrosis according to the autoantibody status: a retrospective cohort study

BMC Pulmonary Medicine, 2021
Background Pirfenidone is an anti-fibrotic agent shown to slow the progression of idiopathic pulmonary fibrosis (IPF). However, its effectiveness in association with serological autoimmune features in IPF remains unclear.
Myung Jin Song, Sang Hoon Lee, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Joon Chang, Song Yee Kim   +7 more
doaj   +1 more source

Comprehensive autoantibody profiling in systemic autoimmunity by a highly-sensitive multiplex protein array

Frontiers in Immunology, 2023
Comprehensive autoantibody evaluation is essential for the management of autoimmune disorders. However, conventional methods suffer from poor sensitivity, low throughput, or limited availability.
Ai Kuzumi, Yuta Norimatsu, Kazuki M. Matsuda, Chihiro Ono, Taishi Okumura, Emi Kogo, Naoki Goshima, Naoki Goshima, Takemichi Fukasawa, Takemichi Fukasawa, Natsumi Fushida, Motoki Horii, Takashi Yamashita, Asako Yoshizaki-Ogawa, Kei Yamaguchi, Kei Yamaguchi, Takashi Matsushita, Shinichi Sato, Ayumi Yoshizaki, Ayumi Yoshizaki   +19 more
doaj   +1 more source

Short- and Long-Lived Autoantibody-Secreting Cells in Autoimmune Neurological Disorders

Frontiers in Immunology, 2021
As B cells differentiate into antibody-secreting cells (ASCs), short-lived plasmablasts (SLPBs) are produced by a primary extrafollicular response, followed by the generation of memory B cells and long-lived plasma cells (LLPCs) in germinal centers (GCs).
C. Zografou, A. Vakrakou, P. Stathopoulos   +2 more
semanticscholar   +1 more source

Myositis autoantibodies [PDF]

Current Opinion in Rheumatology, 2012
To review recent advances in our understanding of autoantibodies associated with dermatomyositis and the autoimmune necrotizing myopathies.Autoantibodies preferentially associated with dermatomyositis include those recognizing Mi-2, MDA5, TIF1γ, and NXP-2. Each of these is associated with a distinct clinical phenotype.
Livia, Casciola-Rosen, Andrew L, Mammen
openaire   +2 more sources