Results 21 to 30 of about 78,014 (306)

Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis. [PDF]

, 2010
The objective of the study was to determine the presence or levels of antibodies (Abs) against caspase-3 and their clinical relevance in systemic sclerosis (SSc). Anti-caspase-3 Ab was examined by enzyme-linked immunosorbent assay and immunoblotting. IgG
Ogawa, Fumihide, Fujimoto, Manabu, Iwata, Yohei, Okazaki, Shihoko, Muroi, Eiji, Hara, Toshihide, Komura, Kazuhiro, Hasegawa, Minoru, Sato, Shinichi, Takenaka, Motoi, Shimizu, Kazuhiro   +10 more
core   +1 more source

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice

Cell Reports, 2015
Immunoglobulin G (IgG) antibodies are major drivers of autoimmune pathology, but they are also used in the form of intravenous IgG (IVIg) therapy to suppress autoantibody activity. To identify the pathways underlying human autoantibody and IVIg activity,
Inessa Schwab, Anja Lux, Falk Nimmerjahn
doaj   +1 more source

Prevalence and Outcome of Serum Autoantibodies in Chronic Hepatitis C Patients Undergoing Direct-Acting Antiviral Treatment

Frontiers in Immunology, 2022
BackgroundChronic immune stimulation by hepatitis C virus (HCV) may cause occurrence of several autoantibodies in infected patients, with or without features of clinically overt autoimmune diseases.
Ciro Romano, Olga Tortorella, Liliana Dalla Mora, Dario Di Stasio, Ausilia Sellitto, Luigi Elio Adinolfi, Aldo Marrone   +6 more
doaj   +1 more source

Enhanced treatment strategies and distinct disease outcomes among autoantibody-positive and -negative rheumatoid arthritis patients over 25 years: A longitudinal cohort study in the Netherlands.

PLoS Medicine, 2020
BackgroundBased on different genetic and environmental risk factors and histology, it has been proposed that rheumatoid arthritis (RA) consists of 2 types: autoantibody-positive and autoantibody-negative RA. However, until now, this remained hypothetical.
Xanthe M E Matthijssen, Ellis Niemantsverdriet, Tom W J Huizinga, Annette H M van der Helm-van Mil   +3 more
doaj   +1 more source

Prevalence and reactivity of anti-melanoma differentiation-associated gene 5 (anti-MDA-5) autoantibody in Brazilian patients with dermatomyositis [PDF]

Anais Brasileiros de Dermatologia, 2018
: Background: There have been no studies to date on the frequency and reactivity of aanti-melanoma differentiation-associated gene 5 (anti-MDA-5) in samples from the Brazilian population with dermatomyositis. Objectives: To analyze this autoantibody in
Isabela Bruna Pires Borges, Marilda Guimarães Silva, Samuel Katsuyuki Shinjo   +2 more
doaj   +1 more source

Does diabetes appear in distinct phenotypes in young people? Results of the diabetes mellitus incidence Cohort Registry (DiMelli). [PDF]

PLoS ONE, 2013
INTRODUCTION: The diabetes mellitus Incidence Cohort Registry (DiMelli) aims to characterize diabetes phenotypes by immunologic, metabolic, and genetic markers.
Katharina Warncke, Miriam Krasmann, Ramona Puff, Desirée Dunstheimer, Anette-Gabriele Ziegler, Andreas Beyerlein   +5 more
doaj   +1 more source

Autoantibody to GNAS in Early Detection of Hepatocellular Carcinoma: A Large-Scale Sample Study Combined with Verification in Serial Sera from HCC Patients

Biomedicines, 2022
The aim of this study was to explore the value of autoantibody to GNAS in the early detection of hepatocellular carcinoma (HCC). In a large-scale sample set of 912 participants (228 cases in each of HCC, liver cirrhosis (LC), chronic hepatitis B (CHB ...
Xiao Wang, Keyan Wang, Cuipeng Qiu, Bofei Wang, Xiaojun Zhang, Yangcheng Ma, Liping Dai, Jian-Ying Zhang   +7 more
doaj   +1 more source

Synovial and serum B-cell signature of autoantibody-negative rheumatoid arthritis versus autoantibody-positive rheumatoid arthritis and psoriatic arthritis

, 2023
Objectives: Autoantibody-negative rheumatoid arthritis (RA) differs from autoantibody-positive RA in several clinical aspects, possibly underpinned by pathogenetic differences. At present, the role of adaptive immune responses in autoantibody-negative RA
De Stefano, Ludovico, Iolanda Mazzucchelli, Emanuele Bozzalla Cassione, Montecucco, Carlomaurizio, Terenzj Luvaro, Carlomaurizio Montecucco, Manzo, Antonio, Bozzalla Cassione, Emanuele, Xoxi, Blerina, Mazzucchelli, Iolanda, Ludovico De Stefano, Silvia Rossi, Antonio Manzo, Blerina Xoxi, Bugatti, Serena, Serena Bugatti, Rossi, Silvia, Luvaro, Terenzj   +17 more
core   +1 more source

Genetics and autoantibodies

Immunologic Research, 2013
Autoimmune diseases (ADs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens. The pathogenic hypothesis comprises a complex interaction between genetic, environmental and hormonal factors that interact with an individual over time generating a dysregulation of the immune system leading to disease development ...
PERRICONE, CARLO, Nancy Agmon Levin, CECCARELLI, FULVIA, VALESINI, Guido, Juan Manuel Anaya, Yehuda Shoenfeld   +5 more
openaire   +3 more sources

Triple-modality autoantibody reduction regimen.

, 2021
Triple-modality autoantibody reduction regimen.
Vincent G. Valentine (7465325), Takudzwa Mkorombindo (11747534), Kevin G. Dsouza (11747540), Fei Fei (794241), Sierra C. Simmons (11747537), Huy P. Pham (10708849), Steven R. Duncan (7465328), Thi K. Tran-Nguyen (7465316), Tejaswini Kulkarni (716851), Luisa D. Quesada-Arias (11747531), Tracy Luckhardt (7465322)   +10 more
core   +1 more source