Results 131 to 140 of about 914,783 (319)

Relationship between autoimmune thyroid antibodies and anti-nuclear antibodies in general patients

Frontiers in Endocrinology
BackgroundThere is no doubt that both Hashimoto thyroiditis and Graves’ disease are autoimmune thyroid diseases (AITDs), but the relationship between anti-nuclear antibody (ANA) and AITDs is poorly studied. The association between thyroid autoantibody levels and ANA positivity was evaluated to assess the role of ANA in AITDs.MethodsWe conducted an ...
Yi Ruan, Yi Ruan, Xian-pei Heng, Liu-qing Yang, Wei-dong He, Liang Li, Zhi-ta Wang, Su-ping Huang, Qi-wei Chen, Qi-wei Chen, Zhuang Han, Zhuang Han   +11 more
openaire   +3 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Paratope plasticity determines anti-HER2 (4B5) antibody specificity

mAbs
The PATHWAY anti-HER2/neu (4B5) Rabbit Monoclonal Primary Antibody immunohistochemistry (IHC) assay is used to identify patients eligible for anti-HER2 targeted therapy.
P. Daniel Warren, Terry H. Landowski, Mark S. Dodson, Adnan Gulzar, John D. Palting, Erika Walker, Penny Towne, Margaret H. Smith   +7 more
doaj   +1 more source

Prevalence and clinical correlation of cytoplasmic anti-nuclear antibody patterns in a tertiary care hospital

, 2021
Meera Mohan, A. Neelima, Vijay Dharma Teja   +2 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Evaluation of Auto-antibody Profiles in Patients with Tuberculosis

Diyala Journal of Medicine, 2018
Background: Tuberculosis remains a major public health problem internationally, causing 9.6 million new cases and 1.5 million deaths worldwide, Tuberculosis (TB) has become one of the most important diseases in the past two decades.
Mohammad Hadi Faris, Ahmed Methab Athab, Rokan M Fadhil   +2 more
doaj   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Duplex Vertical-Flow Rapid Tests for Point-of-Care Detection of Anti-dsDNA and Anti-Nuclear Autoantibodies

Biosensors
The goal of this study is to develop a rapid diagnostic test for rheumatic disease and systemic lupus erythematosus (SLE) screening. A novel rapid vertical flow assay (VFA) was engineered and used to assay anti-nuclear (ANA) and anti-dsDNA (αDNA ...
Rongwei Lei, Hufsa Arain, David Wang, Janani Arunachalam, Ramesh Saxena, Chandra Mohan   +5 more
doaj   +1 more source

Acute Pericarditis with High Anti-Nuclear Antibody Titers Following BNT162b2 mRNA COVID-19 Vaccination. [PDF]

Acta Cardiol Sin, 2022
Chen YS, Wu YW, Chiang CH, Lin HH.
europepmc   +1 more source

Anti‐nuclear antibodies in normal human subjects [PDF]

Arthritis & Rheumatism, 1967
J P, Castanedo, J G, White, R C, Williams   +2 more
openaire   +2 more sources