Results 81 to 90 of about 2,742,410 (287)

Impact of obesity on the metabolic control of type 2 diabetes: Results of the Turkish nationwide survey of glycemic and other metabolic parameters of patients with diabetes mellitus (TEMD obesity study)

, 2019
Bu çalışmada sadece Bursa Uludağ Üniversitesi mensuplarının girişleri yapılmıştır.Background: Obesity is the main obstacle for metabolic control in patients with type 2 diabetes. Turkey has the highest prevalence of obesity and type 2 diabetes in Europe.
TEMD Obesity Study Group
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Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Improvement in quality of life, psychological distress and eating disorder risk in people with class 3 obesity in an Australian multidisciplinary weight management program

, 2020
Background: Class 3 obesity (BMI>40kg/m2) can have a substantial effect on physical and mental well-being. This study aimed to understand quality of life, psychological distress and risk of eating disorders in people with class 3 obesity, and the effect ...
Kormas, Nick, Grudzinskas, Kathy, Hay, Phillipa (R12066), Piya, Milan K. (R19111), Kelsey, Kathryn, Chimoriya, Ritesh (S35837), Myint, Kyaw   +6 more
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Change in liver stiffness at 12 months using two-dimensional shear wave elastography in individuals with class 3 obesity

, 2023
Background: Metabolic-associated fatty liver disease (MAFLD) is common among patients with class 3 obesity, and weight loss may result in reduction in this stiffness.
Kormas, Nick, Ho, Vincent (R16852), Grudzinskas, Kathy, Piya, Milan K. (R19111), Chimoriya, Ritesh (R20404), Acosta Reyes, Pamela (S37563)   +5 more
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Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Biomedical and therapeutic potential of marine-derived Pseudomonas sp. strain AHG22 exopolysaccharide: A novel bioactive microbial metabolite

Reviews on Advanced Materials Science
Microbial exopolysaccharides (EPSs) are gaining interest as alternatives to chemical antioxidants and pharmaceuticals. This study mines the promising biomedical and antimicrobial potential of a marine bacterium, a prolific EPS producer, isolated from the
Aloraini Ghfren S., Albureikan Mona Othman I., Shahlol Aisha M. A., Shamrani Taghreed, Daghistani Hussam, El-Nablaway Mohammad, Tharwat Nagwa A., Elazzazy Ahmed M., Basyony Ahmed F., Ghareeb Ahmed   +9 more
doaj   +1 more source

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, EarlyView.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source

Use of partial meal replacement in class 3 obesity in an Australian public weight management program

, 2020
Background: Partial meal replacement (PMR) (one or two per day) is an effective tool for short-term weight loss. Evidence and acceptability for longer term use in people with class 3 obesity (BMI>40kg/m ) are lacking.
Kormas, Nick, Deavin, Natika, Grudzinskas, Kathy, Piya, Milan K. (R19111), Chimoriya, Ritesh (R20404)   +4 more
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