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Diacylglycerol: Efficacy and Mechanism of Action of an Anti‐Obesity Agent
Obesity Research, 2005AbstractObesity is at the forefront of global health issues and directly contributes to many chronic illnesses. Several dietary components show promise in the treatment of obesity, one of which is oil rich in diacylglycerols (DAGs). Present objectives are to examine scientific knowledge concerning DAG to assess evidence supporting the effects on ...
Iwona, Rudkowska +5 more
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Synthesis of a potential anti-obesity agent
1995This chapter examines ICI D7114, which was developed as a possible treatment for obesity and non-insulin dependent diabetes. It looks at animal studies that showed how ICI D7114 acts by stimulating β3-receptors in brown fat tissue and leads to an increase in resting the metabolic rate.
Stan Lee, Graham Robinson
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Centrally Acting Anti-Obesity Agents
2006Publisher Summary This chapter discusses agents that target central pathways involved in controlling food intake, body weight, and reward and that are under active investigation. Only two drugs are currently approved for chronic weight loss treatment—a pancreatic lipase inhibitor called orlistat (Xenical ® ) and a monoamine reuptake inhibitor ...
David Hepworth +2 more
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Multifaceted Effects of Guggulsterone as Anti‐obesity Agent
The FASEB Journal, 2016Obesity is associated with pathological expansion of white adipose tissue (WAT) and is the leading cause of morbidity and mortality worldwide. In this study, we explored the multifaceted effects of guggulsterone (GS), a well‐studied phytosterol for its cholesterol lowering effects, as an anti‐obesity agent.
Azhar, Yusra +2 more
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Nomilin as an Anti-Obesity and Anti-Hyperglycemic Agent
2013Recent scientific findings support the notion that bile acids, which are cholesterol catabolites, are bioactive signaling molecules that function as ligands for the farnesoid X receptor or a G-protein-coupled receptor, TGR5. Through these receptors, bile acids can maintain not only bile acid homeostasis but also lipid and carbohydrate homeostasis.
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Phenolic compounds as natural and multifunctional anti-obesity agents: A review
Critical Reviews in Food Science and Nutrition, 2017Prevalence of obesity worldwide has reached pandemic proportions. Despite the increasing evidence in the implication of phenolic compounds in obesity management, the real effect is not completely understood. The available in vitro and in vivo studies have demonstrated the implication of phenolic compounds in: lowering food intake, decreasing ...
Celia Rodríguez-Pérez +2 more
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Effects of anti-obesity agents on lipid metabolism
2022This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
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Novel derivatives of capsaicin as a potent hypolipidemic and anti-obesity agent
Molecular DiversityCapsaicin is a natural product with multiple biological activities, such as anti-inflammatory, analgesic, weight loss, anti-cancer and cardiovascular disease prevention. However, its further applications have been limited by its strong irritation, poor water solubility, and unsatisfied pharmacological effects.
Feng, Li +4 more
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Novel oral agents in anti‐obesity pharmacotherapy: A narrative review
Diabetes, Obesity and MetabolismAbstract Obesity remains a critical global health issue with profound medical and economic implications. While injectable medications such as semaglutide (Wegovy®) and tirzepatide (Zepbound®) have demonstrated significant efficacy, the
Assaf Buch +3 more
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