Results 61 to 70 of about 136,986 (279)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Existence and Exponential Stability of Anti-Periodic Solutions for Inertial Quaternion-Valued High-Order Hopfield Neural Networks With State-Dependent Delays

open access: yesIEEE Access, 2019
This paper deals with a class of inertial quaternion-valued high-order Hopfield neural networks with state-dependent delays. Without decomposing the considered neural networks into real-valued systems, based on a continuation theorem of coincidence ...
Nina Huo, Bing Li, Yongkun Li
doaj   +1 more source

Anti-periodic solutions for second order differential equations

open access: yesApplied Mathematics Letters, 2011
The authors consider the existence of anti-periodic solutions for the following second order differential equation \[ (p(t)x')'+f(t,x)=0,\tag{1} \] where \(p\in C^1(\mathbb R)\) is a given \(T\)-periodic function, and \(p(t)>0\); \(f\in C^1(\mathbb R\times\mathbb R)\) is a \(T\)-anti-periodic function.
Wu, Rui, Cong, Fuzhong, Li, Yong
openaire   +1 more source

Linear difference equations, frieze patterns and combinatorial Gale transform [PDF]

open access: yes, 2013
We study the space of linear difference equations with periodic coefficients and (anti)periodic solutions. We show that this space is isomorphic to the space of tame frieze patterns and closely related to the moduli space of configurations of points in ...
Morier-Genoud, Sophie   +3 more
core  

On the Effects of Changing the Boundary Conditions on the Ground State of Ising Spin Glasses

open access: yes, 2000
We compute and analyze couples of ground states of 3D spin glass systems with the same quenched noise but periodic and anti-periodic boundary conditions for different lattice sizes.
A. J. Bray   +15 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Traveling wave solutions, dynamic properties and chaotic behaviors of Schrödinger equation in magneto-optic waveguide with anti-cubic nonlinearity

open access: yesResults in Physics, 2023
In this paper, the traveling wave solutions of the model of magneto-optic waveguide with anti-cubic nonlinearity are obtained by using the complete discrimination system for polynomial method, including singular solutions, solitary wave solutions,and ...
Jia-Xuan Tang, Xin Su
doaj   +1 more source

Lyapunov-type inequality for quasilinear systems with anti-periodic boundary conditions [PDF]

open access: yesJournal of Mathematical Inequalities, 2014
In this paper, we establish a new Lyapunov-type inequality for quasilinear systems with the anti-periodic boundary conditions. It improves some result of Wang (17). As an appli- cation, we also obtain lower bounds for the eigenvalues of corresponding systems.
ÇAKMAK, DEVRİM   +2 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Dynamical Behavior and Chaotic Nature of M-Fractional Paraxial Wave Equation With Three Analytical Methods

open access: yesAdvances in Mathematical Physics
This research work provides a comprehensive investigation of the M-fractional paraxial wave equation (M-fPWE) in describing complex optical phenomena in telecommunication systems and nonlinear media, focusing on the dynamical analysis of optical soliton ...
Md. Mamunur Roshid   +4 more
doaj   +1 more source

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