Results 31 to 40 of about 4,034 (217)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Practical Realism: Against Standard Scientific Realism and Anti-Realism

open access: yesStudia Philosophica Estonica, 2012
In this paper, the elaboration of the concept of practical realist philosophy of science which began in the author's previous papers is continued.
Rein Vihalemm
doaj  

Against the pragmatic justification for realism in economic methodology

open access: yesErasmus Journal for Philosophy and Economics, 2011
In recent times, realism in economic methodology has increasingly gained importance. Uskali Mäki and Tony Lawson are the best-known realists within the discipline and even though their approaches are fundamentally different, both provide (among others ...
Simon Deichsel
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

open access: yesFEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile   +8 more
wiley   +1 more source

WITTGENSTEIN AGAINST THE REALISM/ANTI-REALISM DISTINCTION

open access: yesDaimon, 1990
In this Blue Book, Ludwig Wittgenstein puts forward an argument against the general realism/anti-realism distinction in metaphysics. If the argument is right, neither realism nor anti-realism concerning any putative element of reality is permissable.
George M. Strander
doaj  

Essentialism, Metaphysical Realism, and the Errors of Conceptualism

open access: yesPhilosophia Scientiæ, 2008
Metaphysical realism is the view that most of the objects that populate the world exist independently of our thought and have their natures independently of how, if at all, we conceive of them.
E. Jonathan Lowe
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Moral Realism and Anti-Realism in Later Wittgenstein

open access: yesMetaphysics, 2011
By emphasis on cognitive aspect of moral realism, this article surveys various divisions in moral realism and anti-realism and, regarding later Wittgenstein's courses, it explores his views about this matter.
A Sabramiz, S Dabagh
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Amerykańska metafizyka rasy

open access: yesAnaliza i Egzystencja, 2023
American metaphysics of race In the 1990s, a debate about the race began in the United States, in which many philosophers are involved. In philosophy, this debate has become known as the metaphysics of race.
Mieczysław Jagłowski
doaj   +1 more source

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